You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View
Latest Diabetes Articles
Popular Diabetes Articles
Highly Recommended Diabetes Articles
Send a link to this page to your friends and colleagues.
Data from a phase 3 study of the Novo Nordisk drug liraglutide shows that when it is used in combination with glimepiride, it is more effective at reducing A1c's than glimepiride by itself or glimepiride in combination with the drug rosiglitazone.
A phase 3 study is the last step before a drug receives approval from government agencies to go to market. Novo Nordisk currently has applications before the U.S. Food and Drug Administration, the European Medicines Agency, and the Japanese government for approval to market liraglutide as a treatment for type 2 diabetes.
Researchers conducted a 26-week double-blind trial with more than 2,000 type 2 patients. Patients were randomly selected to receive one of the following treatments:
By the end of the study, patients on the liraglutide-glimepiride combination experienced a 1.08 percent (1.2 mg dose group) and 1.13 percent (1.8 mg dose group) reduction in their baseline A1c's, compared to a 0.44 percent reduction in the glimepiride-rosiglitazone group.
The mean weight loss benefit for patients on the liraglutide-glimepiride combination was more than 2 kilograms (about 4.5 pounds) greater than that for patients on glimepiride-rosiglitazone.
Liraglutide is a glucagon-like peptide-1 analog that stimulates the release of insulin when blood sugar levels are elevated and inhibits the release of glucagon from the liver. Taken once daily by injection, the drug often leads to weight loss in patients because it slows gastric emptying, thus delaying the onset of hunger pangs.
A drug like liraglutide is often the second drug that doctors prescribe for type 2s as their disease progresses. Typically, newly diagnosed types 2s start with metformin, which may later be joined by a sulfonylurea like glimepiride.
0 comments - Feb 19, 2009
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.