Type 2 Drug Improves Glucose Metabolization by 41% in Clinical Trial

DiaMedica is convinced that a dysfunctional nerve signal to the liver is a key contributor to the insulin resistance that characterizes type 2 diabetes.

Feb 26, 2009

DM-99, a drug under development by the Canadian drug company DiaMedica, Inc., has just finished a phase 2a "proof of concept" trial with 40 type 2 patients in Europe. Although the company did not release performance figures from the trial, it found them sufficiently encouraging to move further into phase 2 testing.

DM-99 causes tissues to increase the pace at which they take glucose out of the bloodstream. A DiaMedica spokesman said in a press release that DM-99 may both "insulin sensitize and hasten the onset of insulin action." The results of preclinical testing, announced in early 2008, revealed that DM-99 allowed healthy lab animals to metabolize 41 percent more glucose within an hour of receiving the drug than animals not receiving it. 

DiaMedica has a suite of treatments under development for type 2 diabetes, all based on the company's conviction that a dysfunctional nerve signal to the liver is a key contributor to the insulin resistance that characterizes type 2 diabetes. In addition to DM-99, a sister drug, DM-199, which is 40 times more biologically active than DM-99, is scheduled to undergo preclinical testing soon. The company is also in clinical trials with its lead product, DM-71, which has reportedly reduced A1c's and weight, and DM-83, which the company believes may prolong the ability of the pancreas to produce insulin.

Click Here To View Or Post Comments

Categories: A1c Test, Diabetes, Diabetes, Insulin, Medications Research, Type 2 Issues, Type 2 Medications

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...

Click Here To View Or Post Comments

Comments 0 comments - Feb 26, 2009

©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.