Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12 Tips for Traveling With Diabetes
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter
Latest
Popular
Top Rated
Diabetes Health Reference Charts
Nutrition Research Archives
Print | Email | Share | Comments (1)

Lack of a Liver Molecule Skyrockets Blood Fat Levels in Type 2 Mice

Feb 26, 2009

More from the mouse front. German researchers noted a correlation between weight and the liver’s ability to produce LSR: the greater a mouse’s weight, the less able it is to produce a sufficiency of the molecule.

Too little production of a molecule called LSR (lipolysis-stimulated lipoprotein receptor) in the liver sends blood fat soaring to pathological levels in mice with type 2 diabetes and metabolic syndrome, say scientists at the German Cancer Research Center in Heidelberg.

The researchers also found, however, that when the mice were given leptin, a hormone that regulates hunger, their production of LSR was restored to normal levels. Additionally, they lost weight and their blood fat levels normalized. 

LSR, which is found primarily in the liver and the bowel, controls the removal of fat from the blood into the liver. It also controls fat breakdown in the liver itself. In overweight mice with type 2, LSR production is significantly reduced, meaning that little fat reaches the liver. Instead, it remains in the blood, making blood fat levels soar. Too much fat in the blood can lead to such ill effects as cardiovascular problems. 

The German researchers noted that there seems to be a direct correlation between weight and the liver's ability to produce LSR: the greater a mouse's weight, the less able it is to produce a sufficiency of the molecule. 

Future therapies based on this finding could involve administering LSR to type 2 patients who are deficient in it, in combination with leptin.


Categories: Diabetes, Diabetes, Nutrition Research, Professional Issues, Type 2 Issues



You May Also Be Interested In...


Click Here To View Or Post Comments

Comments 1 comment - Feb 26, 2009

©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.