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Insulin For Type 2 Diabetes: Who, When, And Why?


Mar 20, 2009

This article was originally published in Diabetes Health in December, 2007.

Most patients with type 2 diabetes will eventually need insulin to keep their diabetes in control. In general, the sooner insulin is started, the better off the patient will be in terms of preventing complications.

Physicians who treat people with type 2 diabetes face difficult choices when selecting the best medical therapy for each patient. The decision process is further complicated by the fact that because type 2 diabetes is a progressive disease, therapeutic agents that were initially successful may fail five or ten years later.

As recently as 1994, there were only two options for patients with type 2 diabetes: insulin and the sulfonylureas (such as glyburide and glipizide). The good news is that today, seven totally different classes of medications are available, as well as much better insulins. The bad news is that many physicians are more confused than ever, especially when faced with the option of combining two, three, or even more drugs at one time.

In addition, the past several years have seen the advent of six combination drugs (such as Glucovance, Avandamet, and Janumet), with more on the way. Faced with this explosion of therapeutic options, many physicians are reluctant to start insulin therapy even when it is clearly indicated.

Insulin Resistance and Deficiency in Type 2 Diabetes

Most patients with type 2 diabetes suffer from two major defects: insulin resistance and beta cell "burnout." Insulin resistance typically precedes outright diabetes by several years, appearing in adults and children who are overweight, sedentary, and have a genetic predisposition to diabetes. Patients with insulin resistance are often diagnosed with the metabolic syndrome, which predisposes them to both type 2 diabetes and cardiovascular disease.

When food is ingested, insulin is secreted by the beta cells into the bloodstream. The insulin travels to the liver or muscles, where it attaches to receptors on the surface of the cells like a key in a lock. In non-diabetic people, this process allows individual glucose molecules to enter the cells of muscles, liver, and other organs. However, the cells of people with insulin resistance are "turned off" to the insulin key, so much of the glucose cannot enter the cells. The mother is calling, so to speak, but the children are not listening.

The pancreatic beta cells respond to this resistance by making extra insulin, which for a time keeps glucose in the normal range. If people with insulin resistance do not lose weight, exercise, and/or take certain medications, however, their beta cells may lose the ability to produce enough extra insulin to overcome their insulin resistance. That is the second defect in type 2 diabetes: a relative deficiency of insulin.

When the pancreatic beta cells can no longer overcome the insulin resistance, blood sugars begin to rise. Initially, only the post-meal glucose values are elevated, but in time the fasting glucose levels also increase. When fasting glucose tops 125 mg/dl, a patient is considered to have diabetes. It has been shown that when persons are first diagnosed with type 2 diabetes, they have already lost over fifty percent of their beta cell function.

Medications for Type 2 Diabetes

Fortunately, patients with type 2 diabetes often respond to dietary interventions, increased exercise, and weight loss. When more help is needed, oral diabetes medications such as metformin (Glucophage) or a thiazolidinedione drug (Actos or Avandia) can improve glucose levels by overcoming insulin resistance in the liver or muscle. Sulfonylurea drugs such as glipizide or Amaryl and their cousins (Starlix and Prandin) lower glucose levels by stimulating the remaining beta cells to make more insulin.

It is now known that people with type 2 diabetes are deficient in the intestinal hormones called incretins. Incretins are messenger molecules that travel to the pancreas to help beta cells make extra insulin during meals. The new drugs Byetta, Symlin, and Januvia are incretin substitutes. They not only raise insulin levels with meals, but also make that insulin more effective by slowing stomach emptying and reducing the harmful effects of glucagon (another pancreatic hormone that increases glucose).

Byetta and Symlin, both injected medicines, are unique because they produce satiety (a feeling of fullness) that often leads to significant weight loss. Januvia, an oral medication similar to Byetta in function, does not affect satiety or gastric emptying. Consequently, it does not help patients lose weight. On the other hand, it does not cause the nausea that commonly occurs in patients taking higher doses of Byetta.

In animals, these incretin - like drugs seem to prevent the destruction of the beta cells. Although there is no long-term evidence in humans that Byetta, Symlin, or Januvia preserve beta cells, we do know that, unlike the commonly used sulfonylureas, these newer drugs do not cause "burnout" of the beta cells.

(Refer to our Charts page for a complete list of type 2 medications).

When Medications Fail

Some patients can control their diabetes for years with a good diet and exercise routine plus one, two, or even three different medications. However, there are many conditions that may render these drugs either ineffective or no longer safe for the patient. These include:

  • Acute infections or other serious illnesses
  • Pregnancy
  • Major surgery
  • Congestive heart failure
  • Kidney disease
  • Liver disease
  • Use of other drugs (prednisone and some psychiatric medications)
  • Overeating or excessive weight gain
  • Antibodies that destroy beta cells (in people with type 1, misdiagnosed as type 2)
  • Progressive loss of beta cell function over many years

Unfortunately, many people with type 2 diabetes experience progressive loss of beta cell function. Their overworked beta cells seem to burn out, and drugs that were once effective can no longer hold their A1c's below 7%. (For more information on A1c's, see "What Is A1C And What Does It Measure?" and "Perfect Control".)

Starting Insulin

The overwhelming majority of type 2s eventually require insulin to obtain or preserve satisfactory glucose control and an A1c of 7% or less. Research clearly shows that achieving good control early on prevents diabetic complications, including nerve, kidney, eye and heart disease, up to twenty years later.

Deciding exactly when to begin insulin therapy is problematic for physicians who treat type 2 diabetes. Patients' misguided fears about needles, hypoglycemia, and weight gain often lead to reluctance and physician inertia. A recent survey found that fewer than half of all physicians made any change in diabetes therapy even for patients with A1c's of over 9%.

A similar study at Johns Hopkins found that it took an average of 240 days before doctors added insulin or another drug for patients who could not achieve good control. By the time they finally took action, two-thirds of their patients had A1c levels approaching 10%.

Table 1 lists the relative and absolute indications for initiating insulin therapy in patients with diabetes. Even when initiation of insulin is clearly indicated, however, both patients and their physicians are often reluctant to do it. Some patients are needle-phobic, not realizing that modern insulin syringes and insulin pens are virtually painless.

Patients may also be worried about hypoglycemia and weight gain, although both of these concerns can be minimized. In cases where a doctor remains unwilling to start insulin for a patient whose glucose control is not improving even on two or three drugs, the patient should request consultation with an endocrinologist. Table 2 lists common concerns or barriers to initiation of insulin and some proven ways to overcome these obstacles.

In summary, most patients with type 2 diabetes will eventually need insulin to keep their diabetes in control. In general, the sooner insulin is started, the better off the patient will be in terms of preventing complications. Today's modern insulins and treatment regimens (basal-bolus programs) make insulin a user-friendly therapy. Starting insulin early is the key to improved control and a longer and healthier life for all patients with type 2 diabetes.

Table 1: Indications for Starting Insulin

Absolute Relative
  • All patients with type 1 diabetes
  • Ketoacidosis or severe hyperglycemia (blood sugars over 500)
  • Presence of serious infection (for example, pneumonia)
  • Concurrent illness (such as heart attack)
  • During and after major surgery
  • During pregnancy
  • Failure to achieve ideal glycemic control with two or three oral agents
    • A1c over 10%
    • A1c over 7.5 % plus fasting glucose over 250
  • Patients who are underweight or losing weight without dieting
  • Patients who have symptoms from blood sugars over 200
  • Any patient who is hospitalized
  • Patients requiring steroids (such as prednisone) for other disorders
  • Onset of diabetes prior to age thirty, or a duration over fifteen years
  • Complications such as painful diabetic neuropathy

Table 2: How to Overcome Barriers to Starting Insulin

Weight Gain Needle Phobia
  • Continue or add metformin to the insulin.
  • Add Symlin or Byetta (off label) with basal insulin.
  • Have a certified diabetes educator instruct the patient to use an insulin pen.
Hypoglycemia Insulin resistance
  • Use a peakless basal insulin such as Lantus or Levemir.
  • Avoid NPH and pre-mixed insulins such as 70/30.
  • For patients who eat poorly, use a short-acting insulin such as Apidra, Humalog, or Novolog after meals.
  • Continue or add metformin, Actos, Avandia, or Symlin.
  • If the patient requires more than 300 units per day, switch to U-500 insulin.

Related Articles

Why Basal-Bolus Insulin Therapy May Be The Best Choice for Type 2 Diabetes

Nov 27, 2007

Diabetes Is Not A Disease Of Blood Sugar

Dec 3, 2007

In My Opinion: There is No 24-Hour Basal Insulin

Nov 30, 2007

Why Smaller Shots of Insulin Get Absorbed Faster, Peak Sooner, and Are Out of Your System Quicker

Nov 28, 2007


Categories: A1c Test, Actos, Beginners, Blood Sugar, Diabetes, Diabetes, Food, Insulin, Lantus, Losing weight, Low Blood Sugar, Medications Research, Pens, Pharmacy, Professional Issues, Syringes, Type 1 Issues, Type 2 Issues



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Comments

Posted by Anonymous on 29 November 2007

I live in England and earlier this year my gp recommended me for insulin since the metformin wasn't working as well. I had taken myself off the avandia when I gained over 5 pounds in a week when it was doubled by the diabetes nurse from the diabetes clinic.
The diabetes nurse said no to insulin and that's when she doubled the metformin to 2000mg a day and the avandia to 8mg a day.
Well, now I am anemic which seems to be raising my bs and my gp has raised my dose of metformin to the highest dose.
Last week I saw my gp and asked for Byetta. She can't give it to me because I have to have approval from the diabetes clinic.
My gp seems to want to help me but the local diabetes clinic doesn't care. In fact, my last appointment there had been canceled without them telling me. Why was it canceled??They are only seeing insulin users.
What do I have to do to get on insulin? I am constantly running close to 180, which isn't good.

Posted by Anonymous on 29 November 2007

I'm a type-2 who recently started once-a-day insulin, using the Pen. My prior (and unfounded) insulin phobia were related to concerns about injection risks (not pain) and and calculating insulin dosing. I thought that injections had to go into particular places because vaccines go into muscle and some drugs go into veins. That made me wonder if I could be careful enough to inject myself into the right tissue and hit or avoid blood vessles and not inject air, causing an embolism? The answer I found was that the needle on the pen is short enough to avoid the wrong tissue and my injection site solves the other issues. The tummy for example, doesn't seem to have as many nerve endings as some other places, so combined with the thin needle it almost can't be felt. As to dosing, one can start with a base dosage of slow-acting and up it or lower it based on BG reading.

The one issue I'm still working on is matching my dose to my BG reading and "getting my number down". ;-)

I'd recommend to all doctors that when they first tell a patient that they have diabetes, they should immediately expose them to BG meters and Insulin injections by making the patient use both tools for themselves (with 31/33 guage lancets and needles), even if they may be able to avoid insulin or testing. They will lose their concerns and get a glimpse of one treatment they can work to avoid or postpone.

Posted by ricklude on 29 November 2007

HUH?

Allie. What are you trying to say? That, a controled diet & excersize ALONE will do the job. . .for EVERYONE?

I wish this were true in my case.

I tried that route years ago, counting every single carb, putting myself on, what my dietician said, was a "starvation diet" of 1500 cal. daily and excersizing in addition to the physical labor required of my profession.

For four months I did this when diagnosed and my BG meter sometimes could not display a number becouse it was so high! {But, I did loose alot of fatty weight and thined up which, isn't a bad thing for a "husky" diabetic guy.}

Only with the addition of oral meds and a normal diet, did my numbers come down to normal ranges and a few months ago, when they started an upward swing again, I started taking a long acting insulin which is working great.

So much for your big bad drug companies and their "pushed" medications theory. Not every diabetic responds the same way to ANY form of treatment(s).

I will, at least, check out your sites you've posted. Perhaps there is something I could learn within them.

Posted by ricklude on 29 November 2007

Nick.
Ahhhhhh. Yeah.

Posted by Anonymous on 29 November 2007

Good article. I was diagnosed type 2 in March 07. I'm 36, 5'11" and weight 205 lbs.

Learning that my beta cells are already half-dead is sobering and depressing.

I'd like to avoid insulin as much as possible. My last A1C was 6%. Hopefully in "15 years" better treatments will be available so I can remain off of insulin.

Posted by Anonymous on 29 November 2007

Why are you still pushing Avandia. It is a high risk drug

Posted by Anonymous on 29 November 2007

Hi Nicholas,
Can you elaborate on your statement about insulin resistance? "In the continued absence of any such reference it it reasonable to suppose that every type 2 Diabetic 'complication' arises as a result of the treatment of the 'insulin resistance' that was actually keeping type 2 Diabetics healthy in the first place."
This is the first time I have heard that insulin resistance can keep a person healthy. I've only heard that insulin resistance is bad.

Posted by Anonymous on 29 November 2007

The latest research shows that type 2 diabetes is caused by inflammation and not obesity. Exercise and fish oil reduce inflammation. What else can be done to reduce inflammation so that diabetes can be reversed. Why continue to treat the "symptoms" of diabetes with drugs instead of getting to the root cause. What causes inflammation?

Posted by Anonymous on 30 November 2007

Regarding insulin resistance:
I had a GTT test 30 years ago when I was in my 20's because I complained of hypoglycemia. My blood sugar went from 80 at fasting to 200 and then dropped to 40. The doctor told me that when I got older I would gain weight and develop diabetes, which is exactly what happened. I was lean and fit, and now I am fat and diabetic. I control my diabetes with low carbs and exercise, but my body will not lose weight. I have always been insulin resistant, even when I was a lean athlete. I had problems with hypoglycemia, so it makes sense that insulin resistance is a protective mechanism for hypoglycemia.

Posted by Anonymous on 30 November 2007

A question for Nick:
If insulin resistance protects against hypoglycemia, and therefore drugs that increase insulin sensitivity are defeating the protective purpose of insulin resistance, as you stated, "Diabetics are more protected from sudden HYPOgycemia c/o more glucose / insulin resistance ie leaving more glucose in a Diabetic's blood circulation [for feeding brain / optic / nerve cells] rather than glucose being too rapidly shunted-off [eg by GM insulin] into fat / liver / muscle cells ..." Then is exercise counterproductive? When I exercise, my blood sugar plunges, sometimes down to 50. I am type 2 diabetic and control my blood sugar by diet and exercise alone. Apparently, I am under the misunderstanding that low blood sugar is better than high, and since I do not take any insulin or medication, I don't worry about hypoglycemia. Should I worry? Should I increase my carbs to treat/prevent hypoglycemia during exercise? If, as you say, there is zero requirements for carbs, how do I prevent hypoglycemia without eating more carbs?

Posted by Anonymous on 1 December 2007

In this article, Dr. Tanenberg correctly states that oral medications fail in those people in whom antibodies destroy beta cells (in people with type 1, misdiagnosed as type 2). But then the author incorrectly states that, “many people with type 2 diabetes experience progressive loss of beta cell function.” The studies that show progressive loss of beta cell function did not exclude those people who have slow onset Type 1 but have been misdiagnosed as having Type 2 diabetes. When slow onset Type 1’s are excluded from studies looking at beta cell function in Type 2 diabetes, no loss of beta cell function is seen. According to the American Diabetes Association’s own peer-reviewed scientific journal Diabetes (Borg et al. “A 12-Year Prospective Study of the Relationship Between Islet Antibodies and Beta Cell Function At and After the Diagnosis in Patients With Adult-Onset Diabetes,” Diabetes 51 (6): 1754. (2002)) “None of the patients who were islet antibody–negative at diagnosis developed complete beta cell failure during the 12-year period. Indeed, 12 years after diagnosis, fasting P-C-peptide levels in islet antibody–negative patients were not significantly different compared with the levels at diagnosis.” In other words, if you remove the antibody positive patients (people with autoimmune diabetes who have been misdiagnosed as having Type 2 diabetes) from a study of beta cell failure in Type 2 diabetics, no beta cell failure occurs in the true Type 2 diabetics (i.e., those who do not have immune-mediated destruction of the beta cells).

Posted by bird54 on 1 December 2007

Hi Dr. Tanenberg,
You said, "Insulin resistance typically precedes outright diabetes by several years, appearing in adults and children who are overweight, sedentary, and have a genetic predisposition to diabetes."
However, some people who are sedentary and obese never develop diabetes and others who are lean and physically active do develop diabetes. There must be a reason for "insulin resistance" if so many people have it. Taking drugs to make the body more insulin sensitive, and adding more insulin to someone who already has too much, seems to be assaulting our bodies, like force feeding someone who is already full and is screaming, "No more!" Why is there a diabetes epidemic anyway? Why won't anyone get to the root cause?

Posted by bird54 on 1 December 2007

Hi Dr. Tenenberg,
Regarding your statement, "When the pancreatic beta cells can no longer overcome the insulin resistance, blood sugars begin to rise. Initially, only the post-meal glucose values are elevated, but in time the fasting glucose levels also increase. When fasting glucose tops 125 mg/dl, a patient is considered to have diabetes."
That is exactly what happened to me. I was insulin resistant at age 23, my postpranial glucose at a diabetic level, even though I was very lean and physically fit. Later I developed gestational diabetes but returned to normal after delivery. Years later, my fasting blood sugar went to 150 and my Aic was 7.6%. I am no longer diabetic. My A1c is down to 5.9%. This mornning, my fasting BS was 84. I am improving, not getting progressively worse. When I get lots of sleep, exercise, and eat low carbs, my diabetes disappears. Sleep seems to be the main factor, because when I am sleep deprived, my fasting blood sugar continues to rise regardless of exercise and diet. I wonder if the diabetes epidemic is caused by people being stressed by overwork and sleep deprivation.

Posted by bird54 on 2 December 2007

Thanks Nick!
Perhaps many people with diabetes get progressively worse because they work too hard at trying to control their blood sugar (by way of starvation diets and strenuous exercise) rather than getting adequate sleep and relaxation. I feel much better after a relaxing walk and a good night's sleep. I can even eat more carbs if I take a 20 minute walk after meals.

Posted by Anonymous on 2 December 2007

I was Diagnosed Type 2 since 1984, my A1c is at 7 since last year 2006. I found by my own "common sense" 2 Years ago that "Exercise" AFTER meals for 20-30 minutes "LOWERED" my sugar back to 80-100 range! For "YEARS" I WASNOT Exercising AFTER meals: just taking oral meds plus Metformin LIKE MOST Diabetics I have met in my life! Now that my A1c is at 7; I will start some type of insulin because by my own reading diabetic news articles over the years I DIDN'T KNOW I WOULD SOMEDAY HAVE TO START INSULIN! My Doctors "NEVER" mentioned that possibility to me! How MANY other type2's in the world are living like this who "won't admit" they "WILL NEED TO START INSULIN" one day or get COMPLICATIONS as they get older and simply shrug thier shoulders and say quiely: it's my "Diabetes" getting worse!

Posted by Anonymous on 2 December 2007

Good article, but I worry about prolonged hyperinsulinemia and its effects on blood vessel disease, macro and micro. Also it causes weight gain as people snack and eat more to cope with a constant fear of hypoglycemia with barely concious feelings of sugar dropping too low triggering adrenalin and other alarms in the brain. Weight gain causes abdominal obesity increasing destructive hormone levels of hunger hormones, etc making many paradoxically more hungery for carbs and fat after they start a meal. Clearly exercise and insulin sensitizers like actos and glucophage help the resistance part but this alone cannot counteract the weight gain caused by the insulin. Gastroparesis would seem a problem for taking incretins. Is simply going on a strict carbohydrate weight loss diet a few days a month a better approach as I always feel incredibly better physically even though hungry and shaky when I do it in a way the medicines never come close. But as soon as I start to eat fully again, even with the meds, I begin feeling sluggish and gaining weight again. Also omega 3 and 6, vit e, c, and b's,(artificial and fish, veggie, fruit sources) and aspirin should in theory help blood vessel disease along with activity, but does it really?

Posted by bird54 on 2 December 2007

Dear Nick (and anyone else reading this),
In answer to your question, I don't know how many people use diet and exercise alone (without drugs) to control diabetes. I think that when diet and exercise become too frustrating in keeping blood sugars in the normal range, some people resort to drugs because their doctors scare them into believing that they will have a stroke or heart attack. (My doctor scares me so much that it gives me high blood pressure whenever I visit him. I told him that if I were going to have a stroke, it would be in his office and he would be the cause of it.) In addition, I know of people who use drugs as an easy way out, so that they can eat whatever they want.
Yes, it is my opinion that proper rest between meals does help to control blood sugar. Most of us eat on the run and don't take time to relax. We go to bed too late and are jolted out of bed in the morning by alarm clocks, which in itself is distressing. (On weekends, when I sleep in, my blood sugars are normal.)
It makes perfect sense to me that the real disease is hypoglycemia. Basic biology teaches kids about homeostasis, so why can't doctors accept the fact that the human body is able to keep everything in equilibrium? I believe that if we take proper care of our bodies, our bodies will heal themselves.
I agree with your statement, "Any 'WORK' at trying to reduce a blood glucose concentration ... which is raised, by that body, as an adaptative mechanism [to PROTECT that body] is DISTRESSFUL."
You could probably say the same thing about using drugs to control blood pressure and cholesterol.
Here's question for you: If Alzheimer's disease is being called type 3 diabetes because of insulin resistance in the brain, what protective mechanism is at work here? Why would the brain, which depends on glucose, and which makes its own insulin, want to keep out glucose?

Posted by bird54 on 3 December 2007

Nicholas,
Thanks for all the excellent information and links. I've just finished reading most of the studies you referred to and am very excited about it. I'm going to try eating less often and see how I do. My father recently died of Alzheimers at the age of 90. I want to prevent it from happening to me!

Posted by Anonymous on 4 December 2007

Nicholas Dynes Gracey,

I've very curious in your comments. I notice that you keep asking for evidence of the scientific postulates used by doctors in their treatments and yet you seem to keep using references from a BLOG. Indeed very scientific, yes, very evidence based. I hope those credentials you use serve you well, because your concepts on diabetes seem to be a throw-back to the days when the treatment for type 1 diabetes was starvation (qouting your comment: "UNdrugTREATED type 2 Diabetics and other healthy People should test daily with ChemStrips and pause from eating, and drink just water, until their urine is glucose free. The less carbohydrate eaten ... the less time between meals. That is how to CURE type 1 & type 2 Diabetes."
I recall a very interesting outcome of those patients...THEY ALL DIED!!!!!!

Posted by Anonymous on 5 December 2007

To bird54,

Your comments are very well founded, although there are a few other theories to explain insulin resistance...As you indicated glucotoxicity (too much glucose at the level of the cells - note that this is significantly different from "eating too much carbohydrate") is one of the theories. Another one is the concept of lipotoxicity (too much lipid or fat) in which the breakdown products called free fatty acids change the way that the cells respond to the insulin. A third idea (and one that parallels the gluco and lipo-toxicity theories on a molecular level) is that of inflammation, which is in itself a very difficult entity to describe (although we all seem to know what it is...). Some of the chemicals that are increased in the setting of inflammation are cytokines which can also be increased directly by the presence of high glucoses (so I'm not sure why Nick implied earlier that hyperglycemia is safe since these cytokines are very harmful to the body). The bottom line is that the chemical structures that float around in the blood come in contact with the cells of our body and some of these chemicals (be it glucose, free fatty acids, cytokines, something scientists have yet to identify, or some combination thereof) enter the cells and interact with the proteins that are in our cells. These interactions include changing the physical structure of the protein making it so it is unable to do its job (think of it like putting a big wad of gum on a bicycle chain and then trying to go for a ride) - for those who want the science behind this, I encourage you to read about tyrosine phosphorylation of both the insulin receptor and the insulin receptor substrate type 1 (IRS-1) and then compare it the serine phosphorylation which is caused by the free fatty acids and cytokines. The unfortunate reality is that our bodies are very complex organ with lots of things there to try and protect itself from anything that it perceives is "not normal". Indeed that will include both hypoglycemia and hyperglycemia. Perhaps the best question to be asking is what does the body (or more specifically our own body) consider to be "normal"???

Posted by bird54 on 6 December 2007

To Nick and Anonymous,

Nick, Did you read the comments made by "anonymous" dated Dec. 5? I would like your opinion on it.

Anonymous, You said, "The unfortunate reality is that our bodies are very complex organ with lots of things there to try and protect itself from anything that it perceives is 'not normal'. Indeed that will include both hypoglycemia and hyperglycemia. Perhaps the best question to be asking is what does the body (or more specifically our own body) consider to be "normal"???

It would seem that our bodies already know what is "normal" and that is why I think medications can be dangerous. Our bodies have a wisdom of their own and are so complex that researchers have only seen the tip of the iceberg. Every time researchers discover some new enzyme or hormone in the body, they try to find a new drug to counteract it, or mimic it, (or whatever they do)and by interferring in one area, they create a problem in another area, because scientists do not know how the whole organism works. It is like the analogy you used of the "wad of gum in the bicycle chain," except that I am using that analogy to explain how medications gum up the workings of the human body.

The body is always trying to find balance (homeostasis), so my quesion is, "Why does the body get out of whack?" The human race has survived a long time on this earth without the need for medications. Of course, some died, but most adapted and thrived, otherwise we would not be here today. So my opinion is that we have deviated from nature and have consumed far too many calories, eaten too many refined junk foods, been exposed to toxins, and by so doing we have thrown our bodies out of balance. So diabetes and hypoglycemia are reactions to an unnatural lifestyle.

In the mice study, the mice who were fed the "normal" diet had average blood gluoses of 150. The mice that were fed a restricted calorie diet, and the mice that were fed on alternate days, both had blood glucoses of 100. So what is normal? It depends on their diet. Normality changes depending on what one eats. When I fast all day, my blood sugars range from 60 to 80. Is that normal? Yes, it seems so for my body, because that is how my body reacts to fasting. When I eat, my blood sugar rises according to what I eat, and how much I eat. Is that normal? It seems so. Blood sugar fluctuations are a normal response to eating and fasting. So the real question is, "What is healthy?" The results of the mice study show that eating less and eating less often both result in healthier mice.

However, I think type 1 diabetes has a different cause. It is caused by inflammation which causes the body to stop producing insulin. Without insulin, people die. The Toronto study showed that it was inflammation that caused the pancreas to stop producing insulin, and that when the inflammation was reversed, so was the diabetes. If type 1 is solely an autoimmune disease which destroys the beta cells, then how can dead beta cells produce insulin again AFTER the inflammation is gone? That tells me that the beta cells are not destroyed, but just inflammed, which makes them unable to produce insulin. So the cure to type 1 diabetes is to find a cure to inflammation.

Nick, You say that hypoglycemia is the real disease but that diabetes is the body's preferred state as a protective mechanism against hypoglycemia. Could you define "hypoglycemia"? By that, I mean, how low is low? Most of my hypoglycemic symptoms are from rapid dropping of blood sugar and not from being low. For example, while fasting, my blood sugar can be in the 60's with no symptoms. Yet, if I eat a high carb meal, my blood sugar will spike and then drop suddenly, resulting in shaking, sweating, irritability, at 70. It is the rapid drop that gives me my symptoms. I also get symptoms when my blood sugar is rising. Once after exercising, I was surprised to find my blood sugar at 50. I ate some glucose tablets and then the shaking started, as my blood sugar rose quickly to 90.
Does this mean that I am NOT insulin-resistant?

Posted by bird54 on 6 December 2007

To Nick and Anonymous,
Diabetes is a normal response to an abnormal lifestyle.

Posted by bird54 on 6 December 2007

To Anonymous,
I got so caught up in thinking about "what is normal" that I forgot to say "thank you" for your response regarding all the theories on insulin resistance. I will certainly look into "tyrosine phosphorylation" compared to "serine phosphorylation". I have no idea what that means, but I am curious to find out!

Posted by bird54 on 6 December 2007

To Nick,
You said, "PLEASE really do this ... have each & every One of your Doctors identify ANY Peer-reviewed scientific reference, with an UNdrugTREATED control [ie comparing a Diabetic Group entirely UNdrugTREATED], ever been produced, that has ever evidenced that type 2 Diabetics are less healthy UNdrugTREATED ?"
I will ask, however, I don't believe that anyone will ever compare UNdrugTREATED diabetics, because most of the research is funded by drug companies, and all they care about is making money by treating the chronic diseases they invent (like diabetes). If they can label it, then they can treat it.

Posted by bird54 on 7 December 2007

Nick,
How do you define eating "too often"? In the mice study, they fed the animals on alternate days. In your opinion, how often and how much should a person eat? In the mice study, the mice consumed twice as much food on the days they ate, thereby making up the lost calories for the previous day in which they had fasted. For a person with relative hypoglycemia, eating too much can result in huge blood sugar swings. In that case, wouldn't the standard treatment of six small meals be more beneficial in order to stabilize blood sugar? In other words, fast one day, and then graze the next day?

In the human study involving fasting diabetics, they discontinued the fast for those with either hyper or hypoglycemia. Again, HOW low is too low?

There's a book by titled, Adrenal Fatigue, by James L. Wilson. He states, "We have known for almost a century that people who suffer from low blood sugar frequently suffer from adrenal fatigue." Wilson's solution (among other things) is to get eat more often.

In your opinion, was I better off two years ago when my fasting blood sugars and A1c were higher? I thought that by improving my blood sugars I was "reversing" my diabetes, but have I in fact made my disease worse by increasing my episodes of relative hypoglycemia? I have to say honestly that I felt better when my blood sugar was higher than I do now, but as I mentioned earlier, my doctors scared the crap out of me when they diagnosed me with diabetes. It was like a death sentence, so my reaction has been to starve myself and overexercise in order to save my own life.

Posted by bird54 on 8 December 2007

To Nick and others,
If diabetes is caused by relative hypoglycemia, and hypoglycemia is caused by eating too often, then food is the cause of disease. Therefore, eating less often is the cure because it gives the body time to detox.
The question is: Is "food" the cause of this disease, or is food "intolerances"? It is known that many type 1 diabetics also have other autoimmune diseases, namely Celiac Disease (intolerance to the gluten in wheat, barley, and rye.) Studies have also suggested that casein (from milk) may trigger type 1 diabetes. Certain adenoviruses may trigger diabetes. The body mistakes these proteins and viruses with its own organs, triggering an autoimmune response.
In addition, many people react to the proteins in other foods such as eggs, soy, seafood, and corn. People with food allergies/sensitivities also suffer from adrenal fatigue/exhaustion. Food allergies cause relative hypoglycemia. That is one reason why they tell diabetics to test their blood sugar after meals. Some diabetics can tolerate some foods, while others can't. Food sensitivities cause rapid rises in blood sugar followed by rapid falls, resulting in hypoglycemia. Food intolerances also cause inflammation. Inflammation is the cause of all diseases, including cancer, arthritis, and diabetes.
Therefore, eating less often reduces inflammation, thereby curing these diseases.

Posted by AllieB2 on 9 December 2007

rDNA insulin CAUSES more inflammatioon throughout the body. Why would you CONSIDER introducing MORE inflammation to *reduce* blood sugar -- when in Type 2 diabetes -- it is INFLAMMATION that caused it in the first place?

Nowadays, a doctor is expected to prescribe a *fix* for his or her patient and send them on their way. However, taking into consideration NO INSULIN will HELP a TYPE 2 recover -- but rather IMPAIR a person with Type 2 diabetes -- why are people immune to understanding this?

The fact that we look upon insulin treatment for a person with Type 2 diabetes as an *OPTION* completely defies the HIPPOCRATIC OATH -- which states: "To please no one will I prescribe a deadly drug nor give advice which may cause his death."

Folks, even though what Nick says is very complex in wording -- it makes sense!!

The human body is the most miraculous machine on Earth! Allow it to heal itself and you will be gifted with the health He intended you to enjoy.

Posted by bird54 on 9 December 2007

To AllieB2,
You are right. Nick's writing is very complex. I am still trying to comprehend it.

Hi Nick,
I'm still reading and thinking about all of this information, so I'll get back to you. In the meantime, I have another question. You said, "PLEASE really do this ... have each & every One of your Doctors identify ANY Peer-reviewed scientific reference, with an UNdrugTREATED control [ie comparing a Diabetic Group entirely UNdrugTREATED], ever been produced, that has ever evidenced that type 2 Diabetics are less healthy UNdrugTREATED ?"
I understand and agree that there is no evidence that un-drug-treated diabetics are less healthy than drug-treated diabetics. My question: Is there evidence that un-drug-treated diabetics are less healthy than non-diabetics? Is there any evidence that hyperglycemia actually causes complications? If hyperglycemia is the cure to hypoglycemia, does there need to be a cure for hyperglycemia? If you were to list the types of diabetes on a spectrum, what order would you put them and what would come BEFORE type 0 diabetes?

Posted by draulakh on 10 December 2007

Dr Aulakh here.a diabetes specialist from india
I have seen many patients where HbA1C is more than 10,but everytime there FBS comes below 180 mg/dl {capillary}for last 2-3 months.WILL HbA1C be the absolue indication in all these cases for starting insulin therpay.

Posted by bird54 on 10 December 2007

Hi NIck,
WOW! Impressive!
You have convinced me. I've read the links you listed, but I'm not done analyzing them yet, so I may have more question later. As the saying goes ..."inquisitive minds want to know..."
I've been fasting all day (just drinking water) and eating in the evening when I get home from work, Last week I lost 5 pounds. I feel fine--more relaxed and less irritable, probably due to less blood sugar swings.

Posted by bird54 on 12 December 2007

Hi Nick,
I will definitely share this information with others. I have already shared it my friends and coworkers. Keep it up!

Posted by bird54 on 14 December 2007

Hi Nick,
Have you thought about writing a book explaining your theory and cure for diabetes?

Posted by bird54 on 16 December 2007

Hi Nick,
You said, "What (?) would my writing a book add to what Dr Bernarr is already offering RIGHT NOW ... ie a 100% bona-fide cure for type 1 & type 2 diabetes."

I think that a book, explaining all the research to back the claims would seem more credible to anyone who would want the scientific basis for the cure to diabetes.

You said, "How is your understanding of my work different from your understanding of Dr Bernarr's work?"

Dr. Bernarr's website says, "Fast only when you are symptomatic, i.e., when you have symptoms. Eat only when you are genuinely hungry....When you fast, drink only water, lie down and close your eyes. Keep your eyes closed every moment of the 24 hours, every day that you water fast. During a water fast, you must have total physiological rest."

That seems a lot different than eating less OFTEN, as you propose. You imply that a person should eat only one meal a day, to give time for complete digestion, and to allow time for the urine to become glucose-free, before consuming another meal. If, as Dr. Bernarr suggests, a person should rest completely with the eyes closed, that could only be accomplished when one is not working. I have been fasting all day while working, and eating when I get home. I have been ignoring my hunger pangs during the day. I never have glucose in my urine, even after a meal, so what would be the benefit for me to fast, except to cleanse my body, reduce the inflammation, and lose excess body fat?

Dr. Bernarr suggests fasting as a cure to all diseases, not just diabetes. The Bible says, "WHEN you fast", not IF you fast, so it was common practice 2000 years ago for people to fast, whereas nowadays health care practitioners say, "Eat small meals more often, and make sure you eat a nutritious breakfast..."

Dr. Bernarr also suggest strenuous anaeorbic exercises to build muscle because glucose in stored in muscle.

I think that Dr. Bernarr's cure for diabetes is very simple and straighforward. However, I think that many people want more scientific basis for a cure.

How much more simple can "eat right and exercise" be? Yet, people refuse to do it. They would rather take drugs. Sad, huh?

Posted by bird54 on 18 December 2007

Nick said,
"Please summarize, in 5 short paragraphs, the most important issue raised in each of the 5 'diabetes breakthrough' references 2000-2007 [listed immediately above]."

1. Rats that fasted for 72 hr had a reduced plasma insulin level. However, insulin levels in the brain were elevated after a 72 hour fasting period.

2. In mice, hyperglycemia was induced after 48 hours of fasting, but not after 24 hours. Serum insulin levels were low. However, after refeeding for 12 hours, the mice were hyperinsulinimic, insulin resistant and had impaired impaired glucose tolerance. (What is this suggesting--that one should fast no longer than 24 hours?)

3. Intermittent fasting resulted in reduced serum glucose and insulin levels and may protect the brain from disorders such as epilepsy, strokes, Alzheimer's and Parkinson's diseases. Intermittent feeding can enhance health even if the fasting period is followed by a period of overeating.

4. Glucose restriction extends life span of (worms?).

5. Prolonged fasting is safe for type 1 diabetics as long as they reduce their insulin dosage. They had lower insulin levels but higher A1c's (I thought the goal was a lower A1c)

To answer Nick's questions:
1. I was diagnosed with type 2 diabetes in 2005. My fbs was 150 and my A1c was 7.6%
2. I was never given a C-peptide test.
3. My physician told me that I had worn out my beta glands but never did any kind of test to determine the condition of my beta glands.
4. I never had glucose in my urine.
5. Upon diagnosis, I immediately went on a low-carb diet, against my physician's advice, and lowered my A1c to 5.9%, so I was never prescribed any diabetic drugs.
However, in 1990, I had gestational diabetes. They put me on a high carb, low fat diet, which made my diabetes worse. Then I was put on insulin, without a C-peptide test to determine that I needed insulin. I had a bad reaction to insulin. It made my heart race and I felt horrible. When I exercised, I got hypoglycemia. The diabetic nurse told me that my reactions were worse than her "brittle diabetics." They had to keep lowering my dose until I was down to 2 units. Then the physician told me that at that dose, I really didn't need it. When I went into labor, the nurse tried to give me my morning shot of insulin, without even checking my blood sugar, but I refused. I knew that on an empty stomach, and with all that exercise (contractions of labor), I would have gone into insulin shock. I can't believe how ignorant they were. As it was, my baby got stressed, was born with hypoglycemia, and had to be put into ICU for a day.
I don't trust the medical profession any more. They could not prevent my diabetes, even though they knew I was at risk. In fact, one physician told me, "You cannot prevent diabetes. You will get it no matter what you do." Doctors have not given me any good advice about how to treat it. Everything I know about diabetes, I have learned on my own. Whenever I have a check-up, they want to put me on statin drugs and ACE inhibitors. I have more faith in my own body's ability to regulate itself than I do in physicians and prescription drugs.

Posted by bird54 on 18 December 2007

Dr. Tenanburg,
Why do you recommend insulin during pregnancy? On your chart, you listed:

"Indications for Starting Insulin"
"Absolute"
"During pregnancy"

My grandmother had three, fat, healthy babies, all 10 and 12 pounders, with no complications or defects.
My second baby, born in 1993, was a HEALTHY 10 pounds 10 ounces. He was born at 42 weeks. During labor, he showed no signs of distress. His heart rate did not drop during contractions. The nurses kept commenting how much endurance he had. His delivery was natural with no drugs and no epidural. The doctor was surprised to find that he did not have hypoglycemia or a broken collar bone. He was so strong that he could hold his head up. They commented, "This is no newborn--This is a three-month-old!
I'm glad I did not take insulin. My OBGYN did not give me insulin, even though I had glucose in my urine. I just ate healthy foods and exercised.

Posted by bird54 on 21 December 2007

To Nick and anyone else,

Nick's "I-eat-less-OFTEN-I-fast-more-OFTEN" method really does work.
I lost 10 pounds in 2 weeks!
They all say, "Lose weight (if you can) and your diabetes will go away." Easier said than done. I tried low carbs and exercise, but it didn't take off the pounds like "eating-less-often-fasting-more-often."

Posted by bird54 on 25 December 2007

Merry Christmas Nick and Anyone Else!
I've been reading back on all the comments, and wow! There is a lot of information to absorb.
The research supporting “eating less often, fasting more often” is astounding. I think that if one looks at a meal as a "reward" for a hard day's work, then it is easy to fast all day. Now that I eat less often, I get excited about eating dinner, and I look forward to it all day, whereas before, it was a chore--I had to eat breakfast whether or not I was hungry because I didn't want to “ruin my metabolism” by not eating the "most important" meal of the day. I often ate snacks and meals, not because I was hungry, but because I wanted to make sure I got all my nutrients to prevent disease. Now when I look at all the research, it makes sense not to eat so often.

The tinyurl.com/3aypqg link states that “…nutritive calorie restriction increases life expectancy. Accordingly, treatment …with different antioxidants and vitamins prevents extension of life span...questioning current treatments of type 2 diabetes as well as the widespread use of antioxidant supplements.”

Recently I watched an advertisement on TV: A neurosurgeon was promoting his product of antioxidants for brain health. He stated that to get as many antioxidants as were in his product, one would have to consume an enormous amount of food. He showed plates and plates piled full of meats and vegetables-- more than anyone could possibly eat in a day without becoming sick or morbidly obese. And I remember thinking: This does not make any sense to me at all. If humans were meant to eat that much food or take that many pills to get the necessary nutrients, then the human race would have died out long ago.
I think that our hunter-gatherer ancestors survived on a lot less food than we eat today. I’m sure they didn’t have 4-6 meals a day. And they certainly didn’t have grocery stores or fast food restaurants to run to whenever their cupboards were bare.
Modern man abuses his body and then looks for quick fixes in the form or pills and drugs, instead of relying on the wisdom of the ages.

Posted by bird54 on 25 December 2007

Hi Nick and Anyone Else,
A while ago I read an interesting book which explained the genetic reasons for many diseases including type 1 diabetes. The book is titled:
Survival of the Sickest: A Medical Maverick Discovers Why We Need Disease (Hardcover)
by Sharon Moalem (Author), Jonathan Prince (Author)
If memory serves me correctly, the book states that diabetes actually served a purpose in the last ice age--it allowed the body to burn sugar for energy--and that is why type 1 diabetes is more common in Northern Europeans. Using the theories of this book in addtion to all the research you listed, it seems reasonable to conclude that all types of diabetes serve some purpose. We should not view diseases as negative, but attempt to find the reason for them. The book talked about "jumping genes" and how your grandmother's lifestyle had more influence on your genes than your mother. Nowadays scientists are looking for the genetic causes of diseases, as if these "mutations" are harmful, rather than focusing on how these genes benefited us and allowed us to survive the conditions during a particular time in history.

Posted by bird54 on 27 December 2007

The most ridiculous thought of the day:
One should not skip meals or go on a ketogenic diet without their doctor's supervision, yet one can eat unlimited amounts of junk food and candy without any supervision at all!

Posted by bird54 on 29 December 2007

Hi Nick,
It makes sense that eating one meal a day will benefit an overweight type 2 diabetic, but what about an underweight diabetic who needs more calories? Or what about an underweight non-diabetic teenager with Celiac disease (my son)who needs every extra bite of food just to stay alive?
In one of your comments, you referred to a link where fasting improved the symptoms of people with autoimmune diseases, but when they were put back on food (vegan diet) their symptoms returned. If fasting (eating less often) "cures" autoimmune diseases, then the symptoms should not return upon re-feeding. Perhaps, fasting (eating less often) does not cure diseases but only improves it when the offending foods are removed for a period of time.
What will happen to me if I continue to fast until I reach my ideal weight? At what point will I need to eat more often to maintain weight?

Posted by bird54 on 31 December 2007

Hi Nick,
You stated, "For some 30 years Dr Jan Kwasniewski has been successfully treating type 1 Diabetics, without insulin, with a DPP (diabetes dietary protocol) called the "Optimal Diet". '...Type 1 diabetes can almost always be cured. You must reduce the quantity of carbohydrates consumed to 50±15 grams per day. Because 100 grams of protein can produce about 56 grams of carbohydrates. Therefore, it is necessary to consume protein of the highest biological value which is contained in egg yolks, livers and kidneys."
Then you said, "WHY CHOOSE A DPP TO MINIMIZE INFLAMMATION WHEN SOME LOW CARB DIETS CAUSE WEIGHT LOSS BY INFLAMMATION?"
Can you explain what you mean by your last statement, "...some low carb diets cause weight loss by inflammation."?
I thought low carb diets "reduced" inflammation. Low carb diets reduce insulin production/requierements diabetics. Fasting also reduces insulin levels.
I totally agree with you on intermittent fasting, but I am confused about your statement on inflammation and low carb diets.
By the way, you absolutely have to write a book. I just read Good Calories Bad Calories by Gary Taubes. He is a journalist, not a scientist, and all he does is quote other people--so none of his ideas are his own--yet his book is fantastic!

Posted by bird54 on 31 December 2007

Hi Nick,
I'm going to try to summarize your theory of the cause and cure of diabetes. Let me know if this is correct:
Diabetes is caused by relative hypoglycemia. Relative hypoglycemia is caused by eating often, especially meals high in carbohydrates. When one eats, the blood stream is flooded with glucose. The pancreas releases insulin. Insulin transports the glucose into tissues and/or fat cells. As a result, blood sugar drops, resulting in relative hypoglycemia. Relative hypoglycemia causes the brain and nerve cells to be deprived of glucose. The body compensates by becoming insulin resistant, thereby not allowing the glucose to enter the tissues, but instead to remain in the blood stream to supply the brain and nerves. The more one eats, the higher ones blood sugar rises in order to prevent hypoglycemia. Therefore the cure to diabetes is to eat less often so that there are fewer fluctuations in blood sugar and therefore fewer episodes of relative hypoglycemia.
Eating also causes inflammation (due to glucose intolerance and/or food intolerances) When the pancreatic beta cells become inflamed, they stop producing insulin, as a protective mechanism because insulin is what causes hypoglycemia. So diabetes is a vicious cycle that can only be broken by intermittent fasting.
Is this correct?

Posted by bird54 on 5 January 2008

Hi Nick,
I've been eating-less-often, fasting-more-often for about a month now. I'm not hungry. I mostly eat meat and fat with a small amount of carbs. Gary Taubes book, Good Calories, Bad Calories, convinced me (once and for all) that meat and fat is not harmful. I'd always had some doubts about low carb diets because there is so much misinformation out there about the evils of meat and fat. Therefore, I tried to limit my meat and fat consumption, and in effect I was eating less food altogether. I find that one meal a day of sufficient meat and fat is enough for me. Like Joel Kauffman said, "Just remember that fat has a GI of naught, and protein is low; only carb can be very high."
I have a question: Why do I need to test my pH? I am type 2 diabetic, never have sugar in my urine, and only occassionally have trace amounts of ketones in my urine. What would testing pH tell me, and what would I need to do or eat in order to remedy the situation if I found that my urine was too alkaline or acidic?

Posted by bird54 on 5 January 2008

Nick and Anyone Else,
If the Inuits eat only meat and fat, wouldn't their urine be acidic, since they eat no vegetables or other sources of food to balance their pH? They seem to do fine on their diet.

Posted by bird54 on 6 January 2008

PS. I forgot to say that last night's glucose/ketones was a one-time occurrance. I tested my urine several more times last night and it was normal. So my body seems very efficient in dumping glucose quickly and then being done with it. I wonder if I've had sugar in my urine in the past and have never known it because I never tested at the right time, which is a very small window of opportunity for me. Usually, after meals, my blood sugar spikes quickly and then drops.
Another thing I had forgotten about was that when I was first diagnosed with diabetes 2-3 years ago, I would go all day without eating. I was so obsessed with having normal blood sugars that if it was high in the morning, I would fast all day until it was normal, and then I would eat. That was how I lowered my A1c from 7.6 to 6.0 in the first 3 months. It seemed like common sense to me at the time that eating was the cause of high blood sugar and fasting was the answer. I never asked my doctor's advice. I just did what I believed was right. My doctor was amazed at my A1c at my return visit, which I attributed to low carbs, but it may have been benefit of the fasting too.

Posted by bird54 on 12 January 2008

Hi Nick and Anyone Else,
I bought Joel Fuhrman's book, "Fasting and Eating for Health." While I agree with Fuhrman about fasting, I do not agree with his diabetes diet, which is vegetarian. He says that "fat is the chief enemy of the diabetic." He quotes the study where medical students were fed egg yokes, cream, and butter, which resulted in hyperglycemia and insulin resistance.
Nick, you state that insulin resistance is beneficial, so therefore, it is beneficial to eat fat and become insulin resistant. If you don't eat carbohydrates, then you are burning fat for energy, so you don't need much insulin.
Dr. Bernstein's "Diabetes Solution" is a low carb, sufficient fat and protein diet, not a vegetarian diet.
The Atkin's diet is also a meat and fat diet.
Gary Taubes, "Good Calories, Bad Calories" explains how in the 1920's V. Stefansson lived with the Inuit for five years eating only fat and meat. He did not develop any deficiency diseases, and contrary to what others said, he stated that the Inuits cooked their meat and boiled their fish.
The Optimal Diet, used in Poland, recommends high quality protein like eggs and organ meats.
The ADA has for years recommended a low fat, high carbohydrate diet, which has made diabetes worse.
It confuses me when I read one hypothesis based on research, and then read the exact opposite view based on conflicting research. Then I wonder, what am I supposed to eat, nothing at all?! Okay, I'll do that then. I'll fast. I know that is beneficial. But then when I do eat, what am I supposed to eat? I believe that a low carb, high fat diet is the right way to go based on how I feel. I feel better when I eat fat. I feel lousy when I eat carbohydrates, including low carb vegetables. Fats make me feel relaxed and satisfied. Carbohydrates make me feel hyper and irritable, like I am going to jump right out of my skin. After I eat carbs, I have to exercise. I can't sit still, or I fidget and wiggle. Based on how I feel, I'd say that I am extremely glucose intolerant.

Posted by bird54 on 14 January 2008

Hi Nick and Anyone Else,
I bought the Rosedale Diet a few years ago when it first came out. It is very similar to Atkin's and Dr. Bernstein's Diabetes Solution, in that it is a lower carb, higher fat diet (the exact opposite of the ADA recommendations from a few years ago.) It works for me. The only question I have about all of the above-mentioned diets is that they recommend eating several meals a day, as opposed to your Gracey Hypothesis of eating less often. I believe that intermittent fasting/eating is the best way to prevent/control/reverse diabetes. The only question I have is WHAT to eat. I like your idea of using CGM, but that is not yet covered by insurance. Your idea of eating eggs is fine for some people, but eggs is high on the list for allergies. I think that everyone has to experiment with foods with a rotation diet to see which foods can be tolerated. For example, broccoli has a low glycemic index, yet whenever I eat broccoli, my blood sugar spikes. I don't know why I can tolerate some foods and not others.
My sister is allergic to almost everything. She gets severe hypoglycemia, yet she does not have diabetes. I am the only person in my family to ever have diabetes.
My son also has multiple allergies. He does not have diabetes, but he does gets all the symptoms of hypoglycemia: hungry, dizzy and shakey. I had hypoglycemia for years before developing diabetes. Don't food allergies cause a release of adrenaline, resulting in hyperglycemia, followed by a surge of insulin, leading to hypoglycemia?

Posted by bird54 on 14 January 2008

Hi Nick,
I think that you could add to your Gracey Hypothesis something about how food allergies can cause hypoglycemia, and that perhaps over time lead to diabetes(?) What about stress/distress? Can chronic or acute stress (too much cortisol, adrenaline, etc) wear out the beta glands? (That is what my physician told me.) How about toxins(mercury, lead poisoning)? What about mineral deficiencies (magnesium) and other nutritional deficiencies? What about viruses triggering diabetes?
The reason that fasting appeals to me is that regardless of the multiple causes that can trigger hypoglycemia/diabetes, fasting can enable the body to detoxify and heal itself, so that regardless of the cause, it can be reversed.

Posted by bird54 on 14 January 2008

Hi Nick,
Regarding your Gracey's Hypothesis of the cause and cure of diabetes, what do you think of this analogy: Celiac Disease is caused by eating gluten which causes antibodies and can trigger an autoimmune response which damages the intestinal villi. Over time, by removing gluten from the diet, the intestines can heal themselves.
In the same way, type 1A (autoimmune) diabetes is caused by something (possibly a virus) that triggers the body to attack its own beta cells. Over time, if the virus or other trigger is removed, will the beta cells rejuvinate themselves?
Both Celiac Disease and Type 1A diabetes have similar genetics: Most have HLA DQ2 or DQ8. If Celiac Disease can be cured by removing gluten, then why can't Diabetes 1A be cured by removing the cause?
Is this why you believe that diabetics can be weaned off insulin after sufficient time and with fasting?

Posted by bird54 on 16 January 2008

Hi Nick,
Regarding Dr. Bernarr's approach: I know an 8 year old girl who was severely near-sighted. She couldn't see anything without her "coke bottle glasses." Her parents/church prayed for her and her eyes were INSTANTLY healed. She never wore glasses again. I also know a little girl who was born with a heart defect. Her parents went to France and brought back some water from a river. She was instantly healed. So I know that miracles happen. The question is, why don't miracles happen more often, or why isn't everyone healed? Also, when healings happen, why doesn't the news media jump all over it and broadcast it all over the world? They just sweep it under the rug so that nobody hears about it. I don't believe everything I hear, but in these two instances, I knew these girls personally, so I KNOW these stories are true.
I think that people put more faith in medical science because miracles are so unpredictable. Some people are healed and others aren't, so people don't want to get their hopes up and be disappointed. They want a "sure" thing. So they put their faith in medicine, but that also disappoints. Drugs have side effects. Surgery leaves scars. Cures that are "just around the corner" never come within reach. A lot of diseases can be prevented by following the laws of nature, ie proper nutrition and rest. However, some diseases/accidents cannot be prevented. In that case, where does one put his faith? In medicine? In prayer? In both? Everyone wants hope, but hope is a fragile thing.

Posted by bird54 on 17 January 2008

Hi Nick and Anyone Else,
Do you realize we have come full circle in these comments? The article above is titled, "Insulin for Type 2 Diabetics..." And here we find from the latest study that INSULIN IS THE PROBLEM! So, why in the world would any doctor give insulin to a type 2 diabetic, when it only makes the disease worse?!

Posted by bird54 on 21 January 2008

If distress causes the digestion to stop so that no nutritients are getting to the cells, then the body would want to raise its blood sugar and become insulin resistant in order to nourish the brain and nerves. Right? What about ketones to nourish the brain? Why doesn't the body burn fat instead of raising the blood sugar? When a person fasts, the body switches from a glucose burning machine to a fat burning machine. Yet, even during fasting, when one is distressed, the body releases hormones: adrenaline and cortisol to raise the blood sugar. During distress, does the brain require more glucose?

Posted by bird54 on 21 January 2008

Hi Nick and Anyone Else,
I am experimenting with the Gracey Hypothesis to see how it affects my diabetes. First I spent 2 weeks eating only once a day. I lost 10 pounds and my blood sugar dropped into the normal range. Then for the next few weeks I got very busy with my job, got less sleep and ate more often (still low carb meals). My fbs crept up into the 120's and my weight crept up about 2 pounds. Next I rested and fasted for 2 days straight and then ate one meal. My blood sugar dropped again to normal and I lost the 2 pounds. I plan to keep using the intermittent-fasting-intermittent eating program. The nice thing about this program is that if you go off the plan, it is very easy to get back on. In addition, eating less often works better for me than eating more often with a low-carb diet.

Posted by bird54 on 27 January 2008

Hi Dr. Tanenberg,

I recently read a book about a type 2 diabetic who completely weaned himself off insulin and all other diabetic drugs.

The book is: Death to Diabetes by DeWayne McCulley. DeWayne went into a coma with a blood sugar of 1337. He was put on insulin and drugs. In four months he was able to reduce his insulin from 60 units to zero and get off all diabetic drugs. He completely reversed his diabetes by diet and lifestyle changes.

If, as you claim, diabetes is a "progressive" disease and therefore most diabetics will eventually require insulin, how do you explain how someone can "regress" from diabetes to become a healthy individual in just FOUR months?

Posted by bird54 on 27 January 2008

P.S. I just think it is ridiculous that people use the word "progressive" when describing diabetes, as if diabetics are "making progress" when they are TOLD that their beta cells have burnt out and they MUST be given drugs and insulin. Dr. Tanenberg states, "The GOOD news is that today, seven totally different classes of medications are available, as well as much better insulins."
Do you really believe this GOOD news? Do you really believe that GM insulin is better? There is nothing "natural" about it. It is made from e-coli and the c-peptide has been removed. It's ridiculous!

Posted by Nicholas Dynes Gracey on 29 January 2008

50+ YEARS OF MINIMAL INJECTED / PUMPED INSULIN
MAXIMIZES HEALTHY DIABETIC EYES [WHY(?)]

KING VERIFYS GRUNWALD'S 20 YEAR EYE HEALTH SECRET...

> 1087 www.tinyurl.com/2d48d5 [juangrun@mail.med.upenn.edu]
> 0807 www.tinyurl.com/2nr6b6 [George.King@joslin.harvard.ed ~ insulin dose > retinopathy > Table 1]



CHANGE TYPE 1A TO TYPE 2 = HEALTHIER EYES?

Halle Berry CHANGED from a type 1A [insulin dependent + insulin antibodies (IA)] OR type 1B [insulin dependent - IA] Diabetic into type 2 [insulin in-dependent +/- IA] Diabetic.

... Who REALLY knows if Halle Berry previously had type 1 diabetes WITH or WITHOUT insulin antibodies? But she apparently really HAS "managed to wean" Herself off GM insulin. Perhaps a greater understanding of "Psycho-Neuro-Immunology" [PNI], "Brain-Protective-Insulin" [BPI] & "relative-HYPOglycemia" are the keys to a potentially rapid Halle Berry like CURE for type 1A [insulin-dependent] diabetes?
http://www.DiabetesHealth.com/read/2007/11/02/5548.html
> www.en.wikipedia.org/wiki/Psychoneuroimmunology



CAUSE OF DIABETES

Eating too OFTEN = Relative-HYPOglycemia-distress = diabetes



3 LAYERS OF EVIDENCE

In the light of: Harry Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Michael Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research AND ... George Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable NOW is the 2007 Gracey HYPOthesis for the CAUSE & CURE of diabetes (?)
> 0367 www.tinyurl.com/2uxb99 [Dr Allan Cott c/o Dr Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Dr Michael Dosch]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu]



> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / Relative-HYPOglycemia-DISTRESS ... the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical ... Please study that HYPO-thesis link, very CAREfully, and communicate any genuine questions / positivising suggestions by email]



…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.29.JAN.2008 @ 22:32hrs c/o DiabetesHealth.com

"The Gracey HYPOthesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-distress]... www.tinyurl.com/yno298
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative-HYPOglycemia-distress ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"

Posted by bird54 on 30 January 2008

Hi Nick and Anyone Else,
Since I started eating less OFTEN, or one meal a day, I've lost 20 pounds in two months! My blood sugars have been great and I feel better than ever. I've been eating mainly a raw food diet (juicing fruits and vegetables, raw egg yokes, raw milk, etc). My blood sugar no longer spikes after meals like it did on a regular diet.

Posted by Nicholas Dynes Gracey on 30 January 2008

.
BEATTY SAYS BIGGER BREASTS & DIABETES ARE BENEFICIAL
> 0108 www.tinyurl.com/2eo4xv [LoveDiabetes.com]

KENDRICK PROVES HIGHER CHOLESTEROL IS BENEFICIAL
> 0907 www.tinyurl.com/28b3vs [Malcolm@llp.org.uk]

SO WHAT IS THE CAUSE OF HEART DISEASE?
> 0701 www.tinyurl.com/2b87mp [Lawrence.Young@yale.edu]



CHANGE TYPE 1A TO TYPE 2 = HEALTHIER HEART?

Halle Berry CHANGED from a type 1A [insulin dependent + insulin antibodies (IA)] OR type 1B [insulin dependent - IA] Diabetic into type 2 [insulin in-dependent +/- IA] Diabetic.

... Who REALLY knows if Halle Berry previously had type 1 diabetes WITH or WITHOUT insulin antibodies? But she apparently really HAS "managed to wean" Herself off GM insulin. Perhaps a greater understanding of "Psycho-Neuro-Immunology" [PNI], "Brain-Protective-Insulin" [BPI] & "relative-HYPO-glycemia" are the keys to a potentially rapid Halle Berry like CURE for type 1A [insulin-dependent] diabetes?
http://www.DiabetesHealth.com/read/2007/11/02/5548.html
> www.en.wikipedia.org/wiki/Psychoneuroimmunology



CAUSE OF DIABETES

Eating too OFTEN = Relative-HYPO-glycemia-distress = diabetes



3 LAYERS OF EVIDENCE

In the light of > Harry Salzer's 1966 "relative-HYPO-glycemia" & Neuro-Psychiatric research, Michael Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research AND >> George Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research >>> how reasonable NOW is the 2007 Gracey HYPO-thesis for the CAUSE & CURE of diabetes(?)
> 0367 www.tinyurl.com/2uxb99 [Dr Allan Cott c/o Dr Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Dr Michael Dosch]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu]



> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / Relative-HYPO-glycemia DISTRESS ... the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical ... Please study that HYPO-thesis link, very CAREfully, and communicate any genuine questions / positivising suggestions by email]



…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.30.JAN.2008 @ 23:40hrs c/o DiabetesHealth.com

"The Gracey HYPOthesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-distress]... www.tinyurl.com/yno298
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative-HYPOglycemia-distress ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"
.

Posted by Nicholas Dynes Gracey on 31 January 2008

Dear Dr Joel G Ray [22:50hrs THU.31.JAN.2008] re Breast size and risk of type 2 diabetes mellitus...

Hi Joel, this email is in relation to your recent research...

> 0108 www.tinyurl.com/2bfv97 [RayJ@smh.toronto.on.ca]

Allison Love Beatty of has done a video interpreting your work in a reasonably novel way...

> 0108 www.tinyurl.com/2eo4xv [LoveDiabetes.com]

The interpretation is that type 2 diabetes is an evolutionary advantage and that Those predisposed to 'beneficial hyperglycemia' are better endowed to procreate and breast feed.

My own thorough review of the research has yet to find any research with an UNdrugTREATED control Group that suggests that insulin resistance & type 2 diabetes is anything other than an evolutionary advantage.

What is your opinion on this?

Your research may well prove to be extraordinarily valuable to supporting this notion.

The initial stages of type 1 diabetes appear to progress via a protective 'insulin resistance phase'...

> 0108 www.tinyurl.com/3dze9q [Polly.Bingley@bristol.ac.uk (IRT1DM) > following protective down-regulation of beta-cell-insulin secretion (HYPO-insulinemia) >> protection from relative-HYPOglycemia distress >>> "...insulin resistance accelerates..." >>>> increasing protection from relative-HYPOglycemia-distress >>>>> to help SLOW and prevent the progression to type 1A diabetes...'].

Any comments upon these ideas and/or my HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / Relative-HYPO-glycemia DISTRESS ... the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical ... Please study that HYPO-thesis link, very CAREfully, and communicate any genuine questions / positivising suggestions by email]


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.31.JAN.2008 @ 23:14hrs c/o DiabetesHealth.com

"The Gracey HYPOthesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-distress]... www.tinyurl.com/yno298
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative-HYPOglycemia-distress ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"

Posted by Nicholas Dynes Gracey on 1 February 2008

Dear Professor Polly J Bingley [23:23hrs FRI.01.FEB.2008] re Insulin Resistance and Progression to Type 1 Diabetes...

Hi Polly, this email is in relation to your recent research as related to Dr Joel Ray's findings re Breast size and risk of Insulin Resistance and Progression to Type 2 Diabetes...

> 0108 www.tinyurl.com/2bfv97 [RayJ@smh.toronto.on.ca].

Allison Love Beatty of has done a video interpreting Dr Ray's work in a reasonably novel way...

> 0108 www.tinyurl.com/2eo4xv [LoveDiabetes.com].

The interpretation is that 'Insulin Resistance' is an evolutionary advantage and that Those predisposed to beneficial 'compensatory HYPER-Glycemia' are better endowed to procreate and breast feed.

My own reasonable thorough review of the research has yet to find any research, including an UNdrugTREATED control Group, that suggests that insulin resistance & type 2 diabetes is anything other than an evolutionary advantage.

What is your opinion on this?

Your 'insulin resistance research' may well prove to be extraordinarily valuable to supporting this notion.

The initial stages of type 1 diabetes appears to progress via a similar protective 'insulin resistance phase' which is only occasionally 'overloaded' into type 1A diabetes...

> 0108 www.tinyurl.com/3dze9q [Polly.Bingley@bristol.ac.uk (IRT1DM) > following protective down-regulation of beta-cell-insulin secretion (HYPO-insulinemia) >> protection from relative HYPO-Glycemia-Distress >>> "...insulin resistance accelerates..." >>>> increasing protection from relative HYPO-Glycemia-Distress >>>>> to help SLOW and prevent the progression to type 1A diabetes...'].


Any comments upon these ideas and/or my HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / relative HYPO-Glycemia-Distress ... the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.01.FEB.2008 @ 23:23hrs c/o DiabetesHealth.com

"The Gracey HYPOthesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-distress]... www.tinyurl.com/yno298
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative-HYPOglycemia-distress ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"
.

Posted by Nicholas Dynes Gracey on 2 February 2008

.
INSULIN RESISTANCE ...
IN THE ABSENCE OF HIGH
CIRCULATING GLUCOSE CONCENTRATIONS...

WHY?

> 0606 www.tinyurl.com/292ulj [rchaparr@aecom.yu.edu, chien@stanford.edu, hughmcd@stanford.edu ~ "insulin resistance ... in the absence of high circulating glucose concentrations"].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.02.FEB.2008 @ 23:32hrs c/o DiabetesHealth.com

"The Gracey HYPOthesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPO-Glycemia-Distress (rHGD)]... www.tinyurl.com/yno298
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative HYPO-Glycemia-Distress (rHGD) ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"
.

Posted by Nicholas Dynes Gracey on 3 February 2008

.
HOW BREASTFEEDING WORKS ...
THREE-FOLD VARIATION OF MILK PER DAY...

ONE MEAL A DAY ... HEALTHY FOR BABIES TOO?

> 0606 www.tinyurl.com/34jew3 [Jacqueline.Kent@uwa.edu.au ~ "...The amount of milk produced depends on the amount of milk removed from the breast. Successful, exclusively breastfeeding babies show a three-fold variation in the amount of milk they take per day, and in the frequency of breastfeeds and amount of milk consumed during each breastfeed. The fat intake of the baby is independent of the feeding frequency. If a baby is growing normally, the mother can be confident that her baby does not need to follow prescribed breastfeeding regimes..."].



4 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.tinyurl.com/2uxb99 [Allan Cott c/o Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Michael Dosch]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org] ~ Michael Ristow]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or my HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / relative HYPO-Glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.03.FEB.2008 @ 23:14hrs c/o DiabetesHealth.com & www.HYPO-thesis.com

"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes ... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes [relative Normo-Glycemia (rNG)] ... www.tinyurl.com/2guhfd
CURED diabetes [relative HYPO-Glycemia-Distress (rHOGD)] ... www.tinyurl.com/yno298
PREVENT ... HYPO-Glycemia-Unawareness (HOGU) ... www.tinyurl.com/2y3zpq
PREVENT relative HYPER-Glycemia-Distress (rHRGD) ... www.tinyurl.com/ynpp4g
PROVIDE relative Normo-Glycemia (rNG) ... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative HYPO-Glycemia-Distress (rHOGD) ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN ...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"
.

Posted by Nicholas Dynes Gracey on 4 February 2008

.
TYPE 2 ADVANTAGE AND SWEETER MILK ?
... OF COURSE MEN DISCRIMINATE FOR ...

BIGGER BREASTS BREASTFEEDING MOMS ...
PROTECTED FROM PRE-CANCEROUS LUMPS ?


> 0707 www.tinyurl.com/27tpvd [maqfp@uol.com.br ~ '...woman with a non-tender mass suggestive of breast carcinoma; biopsy revealed lymphocytic mastopathy. The patient got pregnant, breastfed, and observed the progressive regression of the lesion, with complete disappearance of the solid mass. Three years and three months later, there was no palpable mass at the clinical examination and ultrasound....'].


Diabetes is not a disease ... ... diabetes is the CURE ...
... for relative HYPO-Glycemia-Distress (rHOGD)


4 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.tinyurl.com/2uxb99 [Allan Cott c/o Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Michael Dosch]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org] ~ Michael Ristow]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or my HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / relative HYPO-Glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.04.FEB.2008 @ 21:45hrs c/o DiabetesHealth.com & www.HYPO-thesis.com

"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes ... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes [relative Normo-Glycemia (rNG)] ... www.tinyurl.com/2guhfd
CURED diabetes [relative HYPO-Glycemia-Distress (rHOGD)] ... www.tinyurl.com/yno298
PREVENT ... HYPO-Glycemia-Unawareness (HOGU) ... www.tinyurl.com/2y3zpq
PREVENT relative HYPER-Glycemia-Distress (rHRGD) ... www.tinyurl.com/ynpp4g
PROVIDE relative Normo-Glycemia (rNG) ... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative HYPO-Glycemia-Distress (rHOGD) ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN ...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 5 February 2008

.
WILL RESTAURANTS FEED A "1 MEAL A DAY" CLIENT?
> 0108 www.tinyurl.com/2rra8y [LoveDiabetes.com]

ONE MEAL A DAY ...
INCREASES GLUCOSE INSULIN RESISTANCE ...
HELPS PREVENT RELATIVE-HYPO-GLYCEMIA-DISTRESS ...

> 1107 www.tinyurl.com/2u88dx [MattsonM@grc.nia.nih.gov ~ '... consuming 1 meal per day exhibited ... delayed insulin response in the oral glucose tolerance test compared with subjects consuming 3 meals per day. Levels of ghrelin were elevated in response to the 1-meal-per-day regimen ... '].


4 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.tinyurl.com/2uxb99 [Allan Cott c/o Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Michael Dosch]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org] ~ Michael Ristow]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or my HypO-Thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj ["The Gracey HypO-Thesis" / relative HypO-Glycemia-distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.05.FEB.2008 @ 23:15hrs c/o DiabetesHealth.com & www.HypO-Thesis.com

.
"The Gracey HypO-Thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [relative-Normo-Glycemia (rNG)]... www.tinyurl.com/2guhfd
CURED diabetes [relative-HypO-Glycemia-distress (rHOGd)]... www.tinyurl.com/yno298
PREVENT ... HypO-Glycemia-unawareness (HOGu)... www.tinyurl.com/2y3zpq
PREVENT ... relative-HypeR-Glycemia-distress (rHRGd)... www.tinyurl.com/ynpp4g
PROVIDE ... relative-Normo-Glycemia (rNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HypeR-Glycemia-coma (HRGc)... WATer... www.tinyurl.com/2mcyx6 and
... from HypO-Glycemia-coma (HOGc) ... 100pc FOR Liquidiet ... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
... for ... relative-HypO-Glycemia-distress (rHOGd)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 6 February 2008

.
LESS INSULIN = MORE BETA CELLS
> 0108 http://tinyurl.com/348q8q [LoveDiabetes.com]

ONE MEAL A DAY = LESS INSULIN ...

> 0402 www.tinyurl.com/2po68s [Duvillie@necker.fr ~ '... insulin reduction = up-regulation of beta-cells c/o increased beta-cell manufacture + decreased beta-cell recycling ... evidencing that artificially increasing insulin concentration naturally reduces beta-cell mass & quantity ...'].

WHY?


4 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.tinyurl.com/2uxb99 [Allan Cott c/o Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Michael Dosch]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org] ~ Michael Ristow]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or this HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj [Halle Berry weans from type 1 (less insulin) into type 2 (more beta-cells) / "The Gracey HYPO-thesis" / relative-HYPO-glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.06.FEB.2008 @ 20:40hrs c/o DiabetesHealth.com & www.HYPO-thesis.com

.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [relative-Normo-Glycemia (rNG)]... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPO-glycemia-Distress (rHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPO-glycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... relative-HYPER-glycemia-Distress (rHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... relative-Normo-Glycemia (rNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPER-glycemia-Dehydration-coma (HRDc)... www.tinyurl.com/2mcyx6 &
... from HYPO-glycemia-Distress-coma (HODc) ... 'Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for ... relative-HYPO-glycemia-Distress (rHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 8 February 2008

.
Posted by Nicholas Dynes Gracey on 01 February 2008

.
Dear Professor Polly J Bingley [23:23hrs FRI.01.FEB.2008] re Insulin Resistance and Progression to Type 1 Diabetes...

Hi Polly, this email is in relation to your recent research as related to Dr Joel Ray's findings re Breast size and risk of Insulin Resistance and Progression to Type 2 Diabetes...

> 0108 www.tinyurl.com/2bfv97 [RayJ@smh.toronto.on.ca].

Allison Love Beatty of has done a video interpreting Dr Ray's work in a reasonably novel way...

> 0108 www.tinyurl.com/2eo4xv [LoveDiabetes.com].

The interpretation is that 'Insulin Resistance' is an evolutionary advantage and that Those predisposed to beneficial 'compensatory HYPER-Glycemia' are better endowed to procreate and breast feed.

My own reasonable thorough review of the research has yet to find any research, including an UNdrugTREATED control Group, that suggests that insulin resistance & type 2 diabetes is anything other than an evolutionary advantage.

What is your opinion on this?

Your 'insulin resistance research' may well prove to be extraordinarily valuable to supporting this notion.

The initial stages of type 1 diabetes appears to progress via a similar protective 'insulin resistance phase' which is only occasionally 'overloaded' into type 1A diabetes...

> 0108 www.tinyurl.com/3dze9q [Polly.Bingley@bristol.ac.uk (IRT1DM) > following protective down-regulation of beta-cell-insulin secretion (HYPO-insulinemia) >> protection from relative HYPO-Glycemia-Distress >>> "...insulin resistance accelerates..." >>>> increasing protection from relative HYPO-Glycemia-Distress >>>>> to help SLOW and prevent the progression to type 1A diabetes...'].


Any comments upon these ideas and/or my HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / relative HYPO-Glycemia-Distress ... the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical].


…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.01.FEB.2008 @ 23:23hrs c/o DiabetesHealth.com

"The Gracey HYPOthesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-distress]... www.tinyurl.com/yno298
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative-HYPOglycemia-distress ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"
.

Posted by Nicholas Dynes Gracey on 8 February 2008

.
Posted by Nicholas Dynes Gracey on 07 February 2008

.
PREGNANCY DIABETES = STRONGER BABIES
> 0108 www.tinyurl.com/2eo4xv [LoveDiabetes.com]


TYPE 2 = TYPE 4 ...


> 0108 www.tinyurl.com/245yn8 [Glucose Insulin Resistance (GIR) ~ '... It is thought to secure glucose supply to the growing fetus...'].
> 1207 www.tinyurl.com/38yarq [Hassan.Shehata@nhs.net ~ '... congenital malformation rate was four to 10-fold higher...'].

WHY?


4 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.Relative-HYPOglycemia.com [Allan Cott c/o Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Michael Dosch]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org] ~ Michael Ristow]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or this HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj [Halle Berry weans from type 1 (less insulin) into type 2 (more beta-cells) / "The Gracey HYPO-thesis" / relative-HYPO-glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.07.FEB.2008 @ 21:32hrs c/o DiabetesHealth.com & www.HYPO-thesis.com

.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [relative-Normo-Glycemia (rNG)]... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPO-glycemia-Distress (rHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPO-glycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... relative-HYPER-glycemia-Distress (rHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... relative-Normo-Glycemia (rNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPER-glycemia-Dehydration-coma (HRDc)... www.tinyurl.com/2mcyx6 &
... from HYPO-glycemia-Distress-coma (HODc) ... 'Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
... for ... relative-HYPO-glycemia-Distress (rHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 8 February 2008

.
WATER DISCRIMINATION = LIFE
> 0108 www.tinyurl.com/2nkgmo [LoveDiabetes.com]

DEHYDRATION = HYPER-GLYCEMIA-COMA

GM INSULIN too soon = BALLOONED BRAIN CELLS ...


> 0207 www.tinyurl.com/2gjcwh [Cerebral Edema ~ '...avoid administering insulin ... UNTIL ... 1 to 2 hours after starting fluid replacement therapy...']
> 0100 www.tinyurl.com/ypozqv [RosenAL@peds.ufl.edu Arlan L Rosenbloom ~ '...rehydration, REhydration, REHYDRATION...'].


WHY?


4 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.Relative-HYPOglycemia.com [Allan Cott c/o Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Michael Dosch]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org] ~ Michael Ristow]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or this HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj [Halle Berry weans from type 1 (less insulin) into type 2 (more beta-cells) / "The Gracey HYPO-thesis" / relative-HYPO-glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.08.FEB.2008 @ 21:23hrs c/o DiabetesHealth.com & www.HYPO-thesis.com

.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [relative-NormoGlycemia (rNG)]... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-Distress (rHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... relative-HYPERglycemia-Distress (rHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... relative-NormoGlycemia (rNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-coma (HRDc)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODc) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... relative-HYPOglycemia-Distress (rHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by bird54 on 8 February 2008

Hi Nick, Dr Tanenberg and Anyone else,

I think I should highlight to DiabetesHealth.com readers the alarming discrimination that can occur between type 1 & type 2 diabetics --
http://alliesvoice.com/2008/02/04/allies-voice-diabetes-does-not-discriminate--so-why-should-mississippi.aspx#comment-817204

" -- Hi Bettercell,
When a group is singled out from the others, it is called discrimination. If the entire world has a diabetes epidemic, and the entire world population lives an unhealthy lifestyle and eats unhealthy foods, then how can anyone single out Type 2 Diabetics, when all people (thin, obese, diabetics, non-diabetics), do the same? That is discrimination.

When a thin person eats junk food, they are not blamed for their thinness. When a fat person eats junk food, they ARE blamed for their fatness. However, when a fat person lives a healthy lifestyle they are still placed in the "big fat slob" category and blamed for what they have little or no control over. That is discrimination.

How can you say…" the majority of those with Type 2 …continue to consume foods in the very same way that had provided a creation for their Illness…" How do you know what the 'majority' of those with T2D do or do not do? Do you follow them around all day watching what they eat or don't eat, or how much they exercise or don't exercise? How can you say that 'most' have created their own illness, when in fact, 'most' are living the same lifestyle as the majority of the population? That is discrimination.

There are both thin and fat people who live UNhealthy lifestyles and do NOT get diabetes. And there are both thin and fat people who DO live healthy lifestyles and DO get diabetes.

And how can you say that 'most' T1Ds live a healthy lifestyle when they live in the same population and are exposed to the same junk food that everyone else is exposed to? How do you know that 'most" T1Diabetics follow a healthy lifestyle when they follow the ADA recommendations, (which until just recently) was an UNhealthy high carbohydrate, low fat diet?

In order NOT to discriminate, one needs to look at each individual person to determine if they live a healthy lifestyle or not. NO diabetic should ever be discriminated against—so how can you to IMPLY that T1Ds are somehow "superior" because they did not contribute to their illness, while 'most' T2Ds are weak- willed 'SLOBS' who contributed to their own illness? That IS discrimination.

Sarah asked me this, "Did you ever have an eating disorder?
MY personal hypothesis is that your body became [adapted] to starving and acquired insulin resistance.
Basically, you screwed yourself over."

See what I mean about discrimination and blame? Since Sarah cannot explain how I got T2D, she imagines that I must have caused it myself. She thinks that she is immune from blame because she got it as a baby. Well, the TRUTH is that I have never had an eating disorder and I never dieted. I was one of those 'lucky' people who could eat like a horse and never gain weight. I didn't get diabetes until I was older, despite a healthy lifestyle.

So why all the blame? Am I blaming T1Ds for their disease? No. So why do you T1Ds continue to blame T2Ds for their disease? It's called discrimination! -- ".

Posted by Nicholas Dynes Gracey on 9 February 2008

.
Posted by Nicholas Dynes Gracey on 01 February 2008
Posted by Nicholas Dynes Gracey on 08 February 2008

.
Dear Professor Polly J Bingley [23:23hrs FRI.01.FEB.2008] re Insulin Resistance and Progression to Type 1 Diabetes...

Hi Polly, this email is in relation to your recent research as related to Dr Joel Ray's findings re Breast size and risk of Insulin Resistance and Progression to Type 2 Diabetes...

> 0108 www.tinyurl.com/2bfv97 [RayJ@smh.toronto.on.ca].

Allison Love Beatty of has done a video interpreting Dr Ray's work in a reasonably novel way...

> 0108 www.tinyurl.com/2eo4xv [LoveDiabetes.com].

The interpretation is that 'Insulin Resistance' is an evolutionary advantage and that Those predisposed to beneficial 'compensatory HYPER-Glycemia' are better endowed to procreate and breast feed.

My own reasonable thorough review of the research has yet to find any research, including an UNdrugTREATED control Group, that suggests that insulin resistance & type 2 diabetes is anything other than an evolutionary advantage.

What is your opinion on this?

Your 'insulin resistance research' may well prove to be extraordinarily valuable to supporting this notion.

The initial stages of type 1 diabetes appears to progress via a similar protective 'insulin resistance phase' which is only occasionally 'overloaded' into type 1A diabetes...

> 0108 www.tinyurl.com/3dze9q [Polly.Bingley@bristol.ac.uk (IRT1DM) > following protective down-regulation of beta-cell-insulin secretion (HYPO-insulinemia) >> protection from relative HYPO-Glycemia-Distress >>> "...insulin resistance accelerates..." >>>> increasing protection from relative HYPO-Glycemia-Distress >>>>> to help SLOW and prevent the progression to type 1A diabetes...'].


Any comments upon these ideas and/or my HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj ["The Gracey HYPO-thesis" / relative HYPO-Glycemia-Distress ... the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical].


…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.01.FEB.2008 @ 23:23hrs c/o DiabetesHealth.com

"The Gracey HYPOthesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity... www.tinyurl.com/3cw8eu
CURE diabetes... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-distress]... www.tinyurl.com/yno298
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
Diabetes is not a disease ... tinyurl.com/2uxb99 ... diabetes is the CURE...
... for relative-HYPOglycemia-distress ... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN...
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-23hours-45minutes-EveryDay-OrMore"
.

Posted by Nicholas Dynes Gracey on 9 February 2008

.
Posted by Nicholas Dynes Gracey on 07 February 2008
Posted by Nicholas Dynes Gracey on 08 February 2008

.
PREGNANCY DIABETES = STRONGER BABIES
> 0108 www.tinyurl.com/2eo4xv [LoveDiabetes.com]


TYPE 2 = TYPE 4 ...


> 0108 www.tinyurl.com/245yn8 [Glucose Insulin Resistance (GIR) ~ '... It is thought to secure glucose supply to the growing fetus...'].
> 1207 www.tinyurl.com/38yarq [Hassan.Shehata@nhs.net ~ '... congenital malformation rate was four to 10-fold higher...'].

WHY?


4 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.Relative-HYPOglycemia.com [Allan Cott c/o Harry M Salzer]
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca ~ Michael Dosch]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org] ~ Michael Ristow]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or this HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj [Halle Berry weans from type 1 (less insulin) into type 2 (more beta-cells) / "The Gracey HYPO-thesis" / relative-HYPO-glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.07.FEB.2008 @ 21:32hrs c/o DiabetesHealth.com & www.HYPO-thesis.com

.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [relative-Normo-Glycemia (rNG)]... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPO-glycemia-Distress (rHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPO-glycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... relative-HYPER-glycemia-Distress (rHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... relative-Normo-Glycemia (rNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPER-glycemia-Dehydration-coma (HRDc)... www.tinyurl.com/2mcyx6 &
... from HYPO-glycemia-Distress-coma (HODc) ... 'Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
... for ... relative-HYPO-glycemia-Distress (rHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 9 February 2008

.
FECES PUTREFACTION INCREASES T1 & T2 AUTO-IMMUNITY
JUICE BAR OR 'SOLIDS' RESTAURANT ?


> 1207 www.tinyurl.com/2akmba [American Colon Therapy Association ~ '...undigested food molecules act as antigens, foreign substances that provoke an immune reaction...']
> 1207 www.Liquidiet.info [May compliment pancreatic VI-peptide (www.tinyurl.com/yrd6uu)]


WHY?


5 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Rosenbloom's 2000 re-hydration controversy, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.Relative-HYPOglycemia.com [Allan Cott c/o Harry M Salzer]
> 0100 www.tinyurl.com/ypozqv [RosenAL@peds.ufl.edu ~ Arlan L Rosenbloom].
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or this HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj [Halle Berry weans from type 1 (less insulin) into type 2 (more beta-cells) / "The Gracey HYPO-thesis" / relative-HYPO-glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.09.FEB.2008 @ 20:40hrs c/o DiabetesHealth.com & www.HYPO-thesis.com

.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [relative-NormoGlycemia (rNG)]... www.tinyurl.com/2guhfd
CURED diabetes [relative-HYPOglycemia-Distress (rHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... relative-HYPERglycemia-Distress (rHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... relative-NormoGlycemia (rNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-coma (HRDc)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODc) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... relative-HYPOglycemia-Distress (rHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 10 February 2008

UNDRUGTREATED PREGNANCY DIABETES
T4 MAKES BABIES HEALTHIER?


> 1195 www.tinyurl.com/2xsof6 [Glucose-Insulin-Resistance (GIR) & above-the-national-average Relative-NormoGlycemia (RNG) are normal phenomenon emerging in the 2rd/3rd trimester of pregnancy to help baby bodybuilding (www.tinyurl.com/3753ts)]


WHY?


5 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Rosenbloom's 2000 re-hydration controversy, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.Relative-HYPOglycemia.com [Allan Cott c/o Harry M Salzer]
> 0100 www.tinyurl.com/ypozqv [RosenAL@peds.ufl.edu ~ Arlan L Rosenbloom].
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or this HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj [Halle Berry weans from type 1 (less insulin) into type 2 (more beta-cells) / "The Gracey HYPO-thesis" / relative-HYPO-glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.10.FEB.2008 @ 23:33hrs c/o DiabetesHealth.com & www.HYPO-thesis.com

.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [Relative-NormoGlycemia (RNG)]... www.tinyurl.com/2guhfd
CURED diabetes [Relative-HYPOglycemia-Distress (RHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... Relative-HYPERglycemia-Distress (RHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... Relative-NormoGlycemia (RNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-Coma (HRDC)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODC) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 11 February 2008

IF ANTIBIOTICS CAUSE ... RELATIVE-HYPOGLYCEMIA-DISTRESS
WHAT CAUSES DIABETES ?


> 1107 www.tinyurl.com/2rxvq5 [...antibiotics are widely employed in treating infectious diseases ... reports of either hyperglycemia or hypoglycemia have appeared in the medical literature ... hypoglycemia usually occurs within the first three days of treatment ... hyperglycemia often occurs later in the treatment course. The hypoglycemia may be profound and difficult to manage. We report 4 patients with hypoglycemia ... and review the relevant literature...(www.tinyurl.com/yoeht6)]


WHY?


5 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Rosenbloom's 2000 re-hydration controversy, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.Relative-HYPOglycemia.com [Allan Cott c/o Harry M Salzer]
> 0100 www.tinyurl.com/ypozqv [RosenAL@peds.ufl.edu ~ Arlan L Rosenbloom].
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or this HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj [Halle Berry weans from type 1 (less insulin) into type 2 (more beta-cells) / "The Gracey HYPO-thesis" / relative-HYPO-glycemia-Distress ... 'the avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical'; and Gracey's unified theory for the CAUSE & CURE of all diabetes].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.11.FEB.2008 @ 23:42hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
.

Posted by Nicholas Dynes Gracey on 12 February 2008

ANTIBIOTIC HYPOGLYCEMIA >
RESCUED BY HYPERGLYCEMIA >
TREATED WITH GM INSULIN >
T2, T1.5 or T0 > T1A or T1B ?


www.tinyurl.com/2rxvq5 > www.tinyurl.com/34kb6f > "You're not a T1. You're not a T2. But, you're hyperglycemic, let's throw some insulin at it." > www.tinyurl.com/ytdkq2 > www.tinyurl.com/yoeht6


WHY?


5 LAYERS OF EVIDENCE...

In the light of: Salzer's 1966 "relative-HYPOglycemia" & Neuro-Psychiatric research, Rosenbloom's 2000 re-hydration controversy, Dosch's 2006 "Psycho-Neuro-Immunology" [PNI] type 1A research, Ristow's 'beneficial glucose-insulin-resistance' research AND ... Eisenbarth's NEW 2008 "Auto-Immunity to Human beta-cell insulin" research ... how reasonable is the Gracey HYPO-thesis?
www.en.wikipedia.org/wiki/Psychoneuroimmunology
> 0367 www.Relative-HYPOglycemia.com [Allan Cott c/o Harry M Salzer]
> 0100 www.tinyurl.com/ypozqv [RosenAL@peds.ufl.edu ~ Arlan L Rosenbloom].
> 1206 www.tinyurl.com/2odurt [HMDosch@sickkids.ca]
> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org]
> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu].


Any comments upon these ideas and/or this HYPO-thesis in relation to the CAUSE of diabetes would be most appreciated...

> 1207 www.tinyurl.com/399utj [Halle Berry weans from type 1 (less insulin) into type 2 (more beta-cells) / "The Gracey HYPO-thesis" / Relative-HYPOglycemia-Distress / The avoidable CAUSE of type 0 / 1B / 2 / 1.5 / 1A / 2A / 3 / 4 diabetes appears substantially identical / A unified theory for the CAUSE & CURE of all diabetes].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.12.FEB.2008 @ 23:50hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [Relative-NormoGlycemia (RNG)]... www.tinyurl.com/2guhfd
CURED diabetes [Relative-HYPOglycemia-Distress (RHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... Relative-HYPERglycemia-Distress (RHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... Relative-NormoGlycemia (RNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-Coma (HRDC)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODC) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 13 February 2008

.
A BLUE SKY >
CAUSE OR EFFECT OF
A SUNNY DAY?

> 0307 www.tinyurl.com/2njjl7 [Par.Stattin@urologi.umu.se]

CHRONIC MINOR HYPERGLYCEMIA >
CAUSE OR EFFECT OF CHRONIC
Relative-HYPOglycemia-DISTRESS?

> 0138 http://tinyurl.com/yvsh3b [Michael Somogyi]
> 0307 www.tinyurl.com/3djqak

…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.13.FEB.2008 @ 21:23hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
CURE diabetes [Relative-NormoGlycemia (RNG)]... www.tinyurl.com/2guhfd
CURED diabetes [Relative-HYPOglycemia-Distress (RHOD)]... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2y3zpq
PREVENT ... Relative-HYPERglycemia-Distress (RHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... Relative-NormoGlycemia (RNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.tinyurl.com/299t3f
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/ys63gk
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-Coma (HRDC)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODC) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is not a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 14 February 2008

.
IS MALE AND/OR FEMALE DIABETES >
CAUSED AND/OR SUSTAINED BY LOSS
OF ZINC CONTAINING SEXUAL FLUIDS?

SEX-DAY PERFORMANCE ENHANCEMENT OR BIRTH-DAY?

> 0896 www.tinyurl.com/3b5hsr [Gisela.Dahlquist@pediatri.umu.se]
> 0208 www.tinyurl.com/2dmqk8 [Ian.MrTao@Gmail.com]

HAPPY VALENTINE'S DAY.

…Warm thanks & Adrenalin Love
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.14.FEB.2008 @ 22:32hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 15 February 2008

.
IS 'MASTURBATION' SUSTAINING 'DIABETIC'
TYPE HYPERGLYCEMIA BY CHRONIC LOSS
OF ZINC-CONTAINING SEXUAL FLUIDS?

SEX 'DAMAGED GOODS' and/or UNSTABLE BLOOD GLUCOSE?

> 0407 www.tinyurl.com/2odhdo {Masturbation video illustrating extreme sexual fluid loss and concomitant potential ZINC deficit induced alpha-cell HYPERglycemia -- There is a different outcome between alpha-cell glucagon ... stimulated relative-HYPERglycemia [EG a horror movie (www.tinyurl.com/2opc5h)] ~ VS ~ eating too OFTEN ... caused acute relative-HYPERglycemia [EG a cake (www.tinyurl.com/32dvnb) and a combination of both in the form of LOSS of sexual fluids as per the referenced video about masturbation.}

> 0407 www.tinyurl.com/2oonjv {'...We propose that during HYPOglycemia the principal signal that initiates glucagon secretion is the detection by alpha-cells of a sudden decrease in ZINC ... stimulates glucagon secretion.'}

> 0108 www.tinyurl.com/yrd6u {Alpha-cells & Epsilon-cells (www.tinyurl.com/2psoy3) secrete ghrelin which inhibits beta-cell insulin release & stimulates growth hormone release from the anterior pituitary (www.tinyurl.com/3exose) AND alpha-cells secrete glucagon which stimulates glucose production in / release from ... the LIVER ... into the blood.}

> 0108 www.tinyurl.com/38c2ek {"...For the record, I am a practcing Catholic who waited until sex for marriage...unlike Ms. Berry. And yet she is "cured" and not me...go figure..."}

> 0208 www.tinyurl.com/24sls8 {continent ~ VS ~ incontinent ... Masturbation causes BOTH females & males much loss of sexual fluids ... but this article highlights the female potential to actively absorb the male fluids which may hint at potential reason for female / male differences in lifespan.

HOW INCONTINENT HAVE YOU BEEN?

…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.15.FEB.2008 @ 19:45hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 16 February 2008

.
IS 'SEX' WITHOUT-INTENT-TO-PROCREATE SUSTAINING
'DIABETIC' TYPE HYPERGLYCEMIA BY CHRONIC LOSS
OF ZINC-CONTAINING SEXUAL FLUIDS?

'CELIBATING' for natural PROTECTION & more stable BLOOD GLUCOSE?

> 0777 www.tinyurl.com/yu3xx9 {Ageing in Drosophilia is modified according to their physiological state. Adult longevity is decreased by sexual activity: in both sexes the life span of virgins is higher. For the same physiological state male longevity is always lower than that of females.}

> 0896 www.tinyurl.com/3b5hsr {Gisela.Dahlquist@pediatri.umu.se ~ Zinc deficiency has shown to increase the risk for diabetes in diabetes-prone experimental animals.}

> 0208 www.tinyurl.com/2dmqk8 {Ian.MrTao@Gmail.com ~ naked PROTECTION}

> 0407 www.tinyurl.com/2odhdo {Masturbation video illustrating extreme sexual fluid loss and concomitant potential ZINC deficit induced alpha-cell HYPERglycemia -- There is a different outcome between alpha-cell glucagon ... stimulated relative-HYPERglycemia [EG a horror movie (www.tinyurl.com/2opc5h)] ~ VS ~ eating too OFTEN ... caused acute relative-HYPERglycemia [EG a cake (www.tinyurl.com/32dvnb) and a combination of both in the form of LOSS of sexual fluids as per the referenced video about masturbation.}

> 0407 www.tinyurl.com/2oonjv {'...We propose that during HYPOglycemia the principal signal that initiates glucagon secretion is the detection by alpha-cells of a sudden decrease in ZINC ... stimulates glucagon secretion.'}

> 0907 www.tinyurl.com/25qqvy {Ian Clark ~ CELIBATING ~ Contraception}

> 0108 www.tinyurl.com/yrd6u {Alpha-cells & Epsilon-cells (www.tinyurl.com/2psoy3) secrete ghrelin which inhibits beta-cell insulin release & stimulates growth hormone release from the anterior pituitary (www.tinyurl.com/3exose) AND alpha-cells secrete glucagon which stimulates glucose production in / release from ... the LIVER ... into the blood.}

> 1007 www.tinyurl.com/2jknrw {Ian Clark ~ CELIBATING ~ Brotherhood & Sisterhood}

> 0108 www.tinyurl.com/38c2ek {"...For the record, I am a practcing Catholic who waited until sex for marriage...unlike Ms. Berry. And yet she is "cured" and not me...go figure..."}

> 0208 www.tinyurl.com/24sls8 {continent ~ VS ~ incontinent ... Masturbation causes BOTH females & males much loss of sexual fluids ... but this article highlights the female potential to actively absorb the male fluids which may hint at potential reason for female / male differences in lifespan.

> 0607 www.tinyurl.com/238xfv {Ian Clark ~ CELIBATING ~ Time}

HOW INCONTINENT SHOULD YOU BE?

…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.16.FEB.2008 @ 23:45hrs c/o DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 17 February 2008

.
IS MALE AND/OR FEMALE NH-INSULIN OVER-DOSING >
CAUSED AND/OR SUSTAINED BY LOSS OF ZINC CONTAINING
SEXUAL FLUIDS AND EATING too OFTEN TO COMPENSATE THAT LOSS?

www.CELIBATOR.com

> 1107 www.tinyurl.com/25l6n2 {Melody Hoadley ~ "...Great blog--if anyone will listen. Some prefer NOT to know the truth, nor to even be pointed in the direction to locate the truth."}

Diabetes is caused by eating too OFTEN.

Insulin dependent diabetes apparently requires Non-Human-insulin [NH-insulin] to prevent a HYPERglycemia-Dehydration-Coma
> 0100 www.tinyurl.com/ypozqv {RosenAL@peds.ufl.edu ~ Arlan L Rosenbloom}

Type 2 Diabetic CURED by eating one SUB15 minute meal every day
> 0208 www.tinyurl.com/ypxbyl {"...I started eating less OFTEN and drinking more water. Now I eat 1 meal a day. It's really easy. My blood sugar is normal within two hours of my daily meal."}

Type 1 Diabetic makes a CONSCIOUS lifestyle change for more than 50% reduction in 'Non-Human-insulin' requirement:-
> 0208 www.DrFuhrman.com/disease/Diabetes.aspx {"...a 22 year old college graduate with Type 1 diabetes since the age of 6 ... He was taking a total of 70 units of insulin daily. He was ... having swings in his glucose levels, too high at times and at other times dangerously low. He also wanted to learn more about nutrition to improve his health ... I was impressed by his intelligence and desire to change his eating habits to better his health ... I explained to him that using 70 units of insulin a day was part of the problem ... Over the next two weeks we GRADUALLY TAPERED his INSULIN and found that he only needed 20 units of Lantus insulin at bedtime and 4 units before each meal for a total of 32 units a day. Almost immediately, with my dietary recommendations, his sugars were running in the favorable range, and he no longer experienced dangerous drops in his blood sugar ... I am convinced, that with the EAT-TO-LIVE diet-style, those with Type 1 diabetes can have a long and disease-free life."}

Eating more than ONE MEAL a day is a lifestyle CHOICE that is leading to EXCESS consumption of NH-insulin.


REQUEST: New organically derived NH-insulin - MAXIMally LONG acting - Designed to help prevent HYPERglycemia-Dehydration-Coma - WHEN - Adopting a Diabetic Dietary Protocol [DDP] to help gradually TAPER any NH-insulin doses to a MINIMUM.

When will the first Type 1 Diabetic be CURED by the DDP of eating one SUB15 minute meal every day?

…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.17.FEB.2008 @ 14:14hrs c/o DiabetesHealth.com & www.HYPO-thesis.com

.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 18 February 2008

.
ANSWERED PRAYERS?

...GLUCOSE / INSULIN RESISTANCE "GIR" IS ALWAYS ... PROTECTIVE?

'...Increasing cellular glucose uptake is a fundamental concept in treatment of DIABETES, whereas nutritive calorie restriction increases life expectancy. We show here that increased glucose SENSITIVITY decreases Caenorhabditis elegans life span, while increased glucose / insulin RESISTANCE extends life expectancy by inducing mitochondrial respiration. The histone deacetylase Sir2.1 is found here to be dispensable for this phenotype, whereas disruption of aak-2, a homolog of AMP-dependent kinase (AMPK), abolishes extension of life span due to impaired glycolysis. Increased glucose / insulin RESISTANCE APPARENTLY promotes formation of reactive oxygen species (ROS), induces catalase activity, and increases oxidative stress resistance and survival rates, altogether providing direct evidence for a hitherto hypothetical concept named mitochondrial hormesis or "mitohormesis." Accordingly, treatment of nematodes with different antioxidants and vitamins prevents extension of life span. In summary, these data indicate that increased glucose / insulin RESISTANCE promotes mitochondrial metabolism, causing increased ROS formation and cumulating in hormetic extension of life span, questioning current treatments of DIABETES as well as the widespread use of antioxidant supplements...'

> 1007 www.tinyurl.com/3aypqg [MRistow@mristow.org] ~ Michael Ristow]


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.18.FEB.2008 @ 23:23hrs c/o www.DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.tinyurl.com/3cw8eu
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :) ... www.CELIBATOR.com
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by bird54 on 19 February 2008

Hi Nick, Dr Tanenberg and Anyone else,

Dr Tanenberg also in relation to your 29 November 2007 comment, above, "Insulin For Type 2 Diabetes: Who, When, And Why?" -- Why is there no detail about meal frequency -- Less often meals -- less often insulin -- less often fat storage? -- Here is my reply to Judy, earlier today, at --
http://alliesvoice.com/2008/02/04/allies-voice-diabetes-does-not-discriminate--so-why-should-mississippi.aspx

" --


2/18/2008 10:44 AM Judy Sadler wrote: "I lost 90 pounds at one time just eating one meal a day and I was very healthy then."
http://alliesvoice.com/2008/02/04/allies-voice-diabetes-does-not-discriminate--so-why-should-mississippi.aspx#comment-837026

Fantastic, Judy!

What a testimony to the benefits of eating just one meal a day!

Eating less OFTEN (less frequently) is better than eating LESS. Eating less OFTEN allows your body to digest each meal MORE completely rather than overloading your liver and digestive system. By eating less OFTEN you are also reducing inflammation.

Have you tried juicing vegetables? I drink my vegetables. I also drink raw organic egg yokes every day and raw milk every 3 or 4 days. My blood sugar barely rises after a liquidiet. I now intersperse some days on 100% liquidiet and some days with solids -- and I notice a difference in my blood glucose levels when I eat solid foods vs. raw liquids.

Your body can get all its nutrients (vitamins and minerals) from your diet.





Please follow this link-- http://yarrow.best.vwh.net/Usda_data/foods_db.html and also look at the nutrients found in fresh raw egg yokes--


http://yarrow.best.vwh.net/Usda_data/foods.cgi?food_num=01125&state_num=2&food_des_size=60.





Fresh organic raw egg yokes--
http://articles.mercola.com/sites/articles/archive/2008/2/19/most-grocery-store-eggs-far-more-likely-to-be-infected.aspx

-- "

Posted by Nicholas Dynes Gracey on 19 February 2008

.
NEEDFUL THINGS?

AUTO-IMMUNE RE-CYCLING OF BETA-CELLS IS A PERFECTLY
HEALTHY WAY OF DOWN-REGULATING INSULIN PRODUCTION
TO HELP PREVENT RELATIVE-HYPOGLYCEMIA-DISTRESS...

ONE MEAL A DAY = LESS INSULIN = MORE BETA-CELL MASS...

> 0402 www.tinyurl.com/2po68s [Duvillie@necker.fr ~ '... insulin reduction = up-regulation of beta-cells c/o increased beta-cell manufacture + decreased beta-cell recycling (aka apoptosis) ... evidencing ... that artificially increasing insulin concentration naturally reduces beta-cell mass & quantity ...'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.19.MAR.2008 @ 23:50hrs c/o www.DiabetesHealth.com & www.HYPO-thesis.com
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.tinyurl.com/32z33w
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDARIAN.com
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.com
http://www.DiabetesHealth.com/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.tinyurl.com/29kvda ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 20 February 2008

.
ANSWERED PRAYERS?

LEVELS OF GHERLIN WERE ELEVATED IN RESPONSE TO ONE-MEAL-EVERY-DAY...

Increased glucose / insulin RESISTANCE [GIR] promotes mitochondrial metabolism ... cumulating in HORMOsis and extension of life span.
> 1007 www.HORMOsis.cOM [MRistow@mristow.org] ~ Michael Ristow]

ONE MEAL A DAY = MORE TSG = MORE BETA-CELL MASS...

> 1107 www.tinyurl.cOM/3akf92 [MattsonM@grc.nia.nih.gov ~ '... Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.

An issue in the field of diet and health is if and how changes in meal frequency affect energy metabolism in humans. The influence of reduced meal frequency without a reduction in energy intake on glucose metabolism was evaluated in normal-weight, healthy male and female subjects.

The study was a randomized crossover design, with two 8-week treatment periods (with an intervening 11-week off-diet period) in which subjects consumed all of their calories for weight maintenance distributed in either 3 meals or 1-meal-per-day (consumed between 4:00 pm and 8:00 pm).

Energy metabolism was evaluated at designated time points throughout the study by performing morning oral glucose tolerance tests and measuring levels of glucose, insulin, glucagon, leptin, gherlin, adiponectin, resistin, and brain-derived neurotrophic factor (BDNF).

Subjects consuming 1-meal-per-day exhibited higher morning fasting plasma glucose levels [Transient Supernormal-Glycemia (TSG)], greater and more sustained elevations of plasma glucose concentrations, and a delayed insulin response in the oral glucose tolerance test compared with subjects consuming 3 meals per day.

Levels of gherlin were elevated in response to the 1-meal-per-day regimen [www.GHERLIN.cOM].

Fasting levels of insulin, leptin, adiponectin, resistin, and BDNF were not significantly affected by meal frequency.

Subjects consuming a single large daily meal exhibit elevated fasting glucose levels and increased morning glucose / insulin RESISTANCE & tolerance associated with a delayed insulin response during a 2-month diet period compared with those consuming 3 meals per day {who were less able to resist sudden increases in glucose into their cells (less GIR)}.

The increased glucose / insulin RESISTANCE & tolerance was reversible and was not associated with alterations in the levels of adipokines or BDNF. ...'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.20.FEB.2008 @ 22:33hrs c/o www.DiabetesHealth.cOM & www.HYPO-thesis.cOM

"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.1MealPerDay.cOM ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 21 February 2008

.
PERFORMANCE ENHANCEMENT?

INTERMITTENT-FASTING HELPS PREVENT DIABETIC NEPHROPATHY...

Intermittent fasting increases glucose / insulin RESISTANCE [GIR] which promotes mitochondrial metabolism cumulating in HORMOsis and extension of life span.
> 1007 www.HORMOsis.cOM [MRistow@mristow.org ~ Michael Ristow]
> 0503 www.Intermittent-Fasting.cOM [Anson@jhu.edu ~ Michael Anson]

ONE MEAL A DAY = MORE GIR = LESS DIABETIC NEUROPATHY...

> 0307 www.tinyurl.com/2nof9z [Tikoo.K@gmail.com ~ '... Intermittent fasting prevents the progression of type 1 diabetic nephropathy in rats and changes the expression of Sir2 and p53.

Tikoo K, Tripathi DN, Kabra DG, Sharma V, Gaikwad AB. Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160 062, India.

Diabetic nephropathy (DN) is one of the main causes of KIDNEY disease and a leading cause of diabetes mellitus related morbidity and mortality.

Recently, SIRTUIN are reported to have emerging pathogenetic roles in cancer, muscle differentiation, heart failure, neurodegeneration, diabetes and aging.

The aim of the present study was to study the role of intermittent fasting (IF) on DN and studying the expression of SIRTUIN ... Sir2 and p53.

At biochemical level, it was found that IF causes significant improvement in blood urea nitrogen (BUN), creatinine, albumin and HDL cholesterol, parameters that are sometimes associated with the development of DN. There parameters suggest that DN may be in-progress but it is other than clear which of the parameters are part of a healing process helping to combat developing DN.

Diabetic rats on IF also show significant, apparently beneficial, changes onset of hypertension.

Interestingly, the expression of Sir2, a NAD dependent histone deacetylase, decreases in diabetic rat kidney and this decrease is overcome by IF.

Evidence is also provided for involvement of mitogen activated protein kinases (MAPK) cascade in mediating the effects of IF as there is reduction in the expression of p38 which gets induced under diabetic condition. This was further accompanied by a decrease in p53 expression.

These findings suggest that IF, by way of a 'One Meal every day' (SUB15 minutes) intermittent-fasting program, should slow, halt or reverse the development of Diabetic neuropathy...'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.21.FEB.2008 @ 17:27hrs c/o www.DiabetesHealth.cOM & www.HYPO-thesis.cOM
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.1MealPerDay.cOM ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 22 February 2008

.
HOW PERFORMANCE ENHANCEMENT?

ONE MEAL A DAY = MORE GHerlin = LESS DIABETIC NEUROPATHY ...

'...Synaptic changes induced by GHerlin are paralleled by enhanced spatial learning & memory. Tamas Horvath, Chairman of Yale Medical School's comparative medicine program says We can use the hormonal discoveries to our cognitive advantage. In each case, the biochemically “hungry” mice ... performed notably better than those with normal levels of the hormone. The finding was startling, but “it makes sense,” Horvath says. In fact, some Biologists believe that human intelligence itself evolved because it made early Hominids more effective Hunters, Gatherers and Foragers ... Facing the LSAT, a final exam or a half-day job interview? Go in mildly hungry, not carbo-loaded ... and ... maintain that edgy state. Such advice, applied on a national scale, might help save our schools...'
> 1206 www.GHerlin.cOM [Tamas.Horvath@yale.edu ~ www.tinyurl.com/2fb4x7]
> 0503 www.Intermittent-Fasting.cOM [Anson@jhu.edu ~ Michael Anson]

INTERMITTENT-FASTING IS NEURO-PROTECTIVE ...

> 1203 www.tinyurl.com/35ehxx [YTache@mednet.ucla.edu ~ '... GHerlin: a novel player in the gut-brain regulation of growth hormone and energy balance.

St-Pierre DH, Wang L, Taché Y.

Faculty of Medicine, Department of Nutrition, Université de Montréal, Montréal, Québec H3C 3J7, Canada.

GHerlin is a newly discovered peptide hormone produced by the stomach that displays potent growth hormone-releasing activity and a stimulatory effect on food intake and digestive function while reducing energy expenditure.

The isolation of GHerlin has led to new insights into how this gastric hormone links the endocrine control of nutritional homeostasis with growth hormone secretion ... through gut-brain interactions.


In adult humans, plasma GHerlin levels rise twofold before a meal and decline to trough levels within 1 h after eating. Likewise, GHerlin levels are elevated by fasting and decreased after refeeding in rats.


In human obesity, GHerlin level is low, which may be related to the high caloric intake, whereas reduction of body weight in obese patients brings the GHerlin level up.

Interestingly, although GHerlin levels are reported to be high in patients undergoing diets, stomach bypass surgery decreased GHrelin levels, suggesting that the size of the stomach may be directly correlated to GHerlin levels...'].


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.22.FEB.2008 @ 20:23hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE ... www.1MealPerDay.cOM ... "I-Fast-Every-23hours-45minutes-OrMore"
.

Posted by Nicholas Dynes Gracey on 23 February 2008

.
HOW FAR UP THE T0 / T1 / T2 / T3 / T4 DIABETIC PERFORMANCE SPECTRUM SHOULD YOU DISCRIMINATE?


www.HookedOnHighPerformance.cOM


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.23.FEB.2008 @ 15:17hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 24 February 2008

.
1 MEAL A DAY = LESS INSULIN = LESS INSULIN ANTI-BODIES [LESS RELATIVE HYPO-GLYCEMIA DISTRESS ?] = MORE BETA-CELL REGENERATION (www.tinyurl.com/2bc3bx) = MORE BETA-CELLS = MORE BETA-CELL C-PEPTIDE = MORE BETTER-HEALTH = TWENTY-ONE-YEARS-AGO ?



> 0187 www.tinyurl.com/2wnutj [Knut.Dahl-Jorgensen@medisin.uio.no ~ '...Increased STIMULATION of insulin anti-bodies during NEW-FASHIONED therapy in contrast to OLD-FASHIONED conventional treatment...

K Dahl-Jorgensen, P Torjesen, KF Hanssen, L Sandvik and O Aagenaes

Forty-five insulin-dependent diabetics were randomized to 1 yr treatment with either continuous subcutaneous insulin infusion (CSII), multiple insulin injections (MI), or continued conventional treatment.

The CSII group used regular insulin only;

The MI group used 4-6 pre-meal injections of regular insulin and intermediate insulin at night; and

The conventional group used two daily injections of combined regular and intermediate insulin.

Only highly purified porcine insulin was used.

Near normo-glycemia was obtained during CSII and MI but during the OLD-FASHIONED conventional treatment WITH PIG INSULIN there was a lack of NORMO-GLYCEMIA.

Anti-bodies against insulin were measured in serum samples by measuring the binding of iodinated porcine insulin to serum after removal of free and anti-body-bound insulin from the samples by acid charcoal.


The percent binding of 125I-labeled insulin increased significantly during MI and CSII but during the OLD-FASHIONED conventional treatment WITH PIG INSULIN there was a lack of INSULIN ANTI-BODIES...'].



> 0108 www.tinyurl.com/3bqcm9 [George.Eisenbarth@uchsc.edu ~ '...Insulin STIMULATES insulin anti-bodies in NOD/human diabetes.

Zhang L, Nakayama M, Eisenbarth GS.

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, USA.

There is increasing evidence that insulin anti-bodies may be central to disease pathogenesis.

Evidence is strongest for the NOD mouse model where blocking immune responses to insulin prevents diabetes, and insulin peptides can be utilized to induce diabetes.


It is apparently not currently clear why insulin anti-bodies are so prominent and frequent...].




HOW DO YOU interpret THE CONSEQUENCES OF THE 1987 RESEARCH TO 21 YEARS OF ENDOGENOUS BETA-CELL C-PEPTIDE PRODUCTION?



…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.24.FEB.2008 @ 19:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 25 February 2008

.
INSULIN FROM SEMEN AND MUNCHAUSENS?

Long acting insulin [www.tinyurl.com/2xhpwr] is created by the addition of PROTAMINE [www.tinyurl.com/yrwyse] obtained from SEMEN [www.tinyurl.com/33x3ge] of river trout.

Adequate hydration [www.tinyurl.com/3d7xoo] and long acting Neutral Protamine Hagedorn aka NPH insulin has been successfully adopted since 1950 [www.tinyurl.com/3dqd5b] for helping prevent HYPER-glycemia COMA [www.tinyurl.com/ypozqv] and retain beta-cell activity [www.tinyurl.com/2u8x47] and associated endogenous insulin [www.tinyurl.com/27oard] and consequent endogenous C-peptide [www.tinyurl.com/ys9wv2] production.

Do Diabetics who refuse [www.tinyurl.com/2arzxs] to DEMAND regular STIMULATED ... C-peptide TESTS [www.tinyurl.com/2fuejn] and medical advice to help maximize the PERFORMANCE of their endogenous C-peptide production [www.tinyurl.com/32j6kl] really have Munchausens [www.tinyurl.com/ye9buf] ?
.

…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.25.FEB.2008 @ 21:14hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 26 February 2008

.
INJECTING BY CHOICE ?

"...The National Vaccine Information Center (NVIC) is a national, non-profit educational organization founded in 1982 {www.tinyurl.com/2hfugn}. NVIC is responsible for launching the vaccine safety and informed consent movement in America in the early 1980's..."


> 0182 www.tinyurl.com/2x8dd3 ~ Champsaur HF, Bottazzo GF, Bertrams J, Assan R, Bach C.

ViroLogic, ImmunoLogic, and Genetic Factors in Insulin-Dependent T1A Diabetes Mellitus...


'... A 16-month-old Girl with a fever. On days 13 to 23, laboratory evidence of 'glucose-in-the-urine' {www.tinyurl.com/2sm9g6} was present, followed by a 2 1/2-month remission, then followed by definitive insulin-dependent diabetes. The involvement of virologic, immunologic, and genetic factors in the pathophysiology was apparently substantiated by the following:-


(1) Petrussis toxin, aka "ISLET-ACTIVATING PROTEIN" in the DTP caused ACUTE vaccine-INDUCED EXCESS production of beta-cell INSULIN leading to Relative HYPO-glycemia Distress {RHOD}; and

(2) Compensatory down-regulation of beta-cells {www.tinyurl.com/2po68s}, to protect the child's CNS from RHOD, c/o elevated islet-cell antibodies {www.tinyurl.com/33gwop} which were above mean levels on days 5 to 12 ... IE one week BEFORE onset of diabetes together with circulating lymphocytes of the Girl at that time that suppressed insulin release from islets, in vitro, also to protect the girl's CNS from RHOD; and

(3) Immunogenetic analysis suggested the Girl had 'thrifty' genetic markers identifying T1 Diabetics as being very efficient at storing food and adapted to eating less OFTEN. It was suggested that the petrussis toxin aka "ISLET-ACTIVATING PROTEIN" was the rate-determining-step causing the T1 diabetes ... but a more reasonable interpretation is that the Girl was eating too OFTEN, at the time of the VACCINE-INDUCED HYPOglycemia 'challenge', leading to additional 'thrifty' INSULIN excesses {www.tinyurl.com/24tw6u} ... this time c/o CHRONIC food-INDUCED EXCESS production of beta-cell INSULIN leading to CHRONIC Relative HYPOglycemia Distress {RHOD} and subsequent ... CNS protective compensatory AUTO-IMMUNTY-INDUCED HYPERglycemia ... which often becomes a chronic condition called T1A diabetes when treated with excess Non-Human Insulin {www.tinyurl.com/3bqcm9} ...'
.

…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.26.FEB.2008 @ 21:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM

.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 27 February 2008

.
Plasma blood glucose concentration STRICTLY above 150 mg/dL (9 mmol/L) and below approximately 350 mg/dL (19 mmol/L) IS APPARENTLY SAFER THAN RAPID REDUCTION OF BLOOD GLUCOSE FROM 270 mg/dl (15 mmol/L) to 90 mg/dl (5 mmol/L) ?


21 YEARS of Relative HYPO-glycemia Distress (RHOD)...

'... Why some cases of retinopathy worsen when diabetic control improves ... the rate of fall of blood glucose concentration and the accompanying reduction in blood flow have been thought to be the trigger ... This suggestion was supported by the finding of Grunwald et al, who showed a 20% reduction of blood flow when blood glucose concentrations fell from about 15 mmol/l to 8 mmol/l ... This "Normo-Glycemic re-entry phenomenon" has puzzled Clinicians ... and ... there is still much to learn about its mechanism ...'
> 1087 www.tinyurl.cOM/2d48d5 {juangrun@mail.med.upenn.edu}
> 0297 www.tinyurl.cOM/yu77y7 {M.Henricsson@telia.com}
> 1097 www.tinyurl.cOM/34lyyj {Lobnig@med.uni-duesseldorf.de}

&

How well is this HYPO-thesis ...

www.tinyurl.cOM/32nqc5

'newly-supported' by this ...


21 DAYS AGO?...

> 0208 www.tinyurl.cOM/2vh2ul {Dario.Giugliano@unina2.it}

University of Warwick, Coventry, U.K.

Much research suggests that blood glucose reduced at rates 'faster than physiologically normal' may determine the risk for cardiovascular diabetic complications.

METHOD/RESULTS: Glucose at two different levels, 180 mg/dl (10 mmol/L) and 270 mg/dl (15 mmol/L), resulted in a ... concentration-dependent ... fasting blood glucose-independent ... induction of both endothelial dysfunction and oxidative stress in both normal and T2 Diabetic Patients.

Eating MORE than one meal a day was simulated by oscillating glucose between 90 mg/dl (5 mmol/L) and 270 mg/dl (15 mmol/L) every 6 hr for 24 hr resulted in further significant INCREASES in endothelial dysfunction and oxidative stress as compared to either continuous 180 mg/dl (10 mmol/L) or 270 mg/dl (15 mmol/L) glucose and that vitamin C from fresh organic raw juice may well prevent and/or reverse any such impairment.

INTERPRETATION: Normo-Glycemic Re-entry, too rapidly, causes RHOD which can have much more deleterious effects than the HEALTHIER relatively constant Relative Super-Normal-Glycemia.
.

…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.27.FEB.2008 @ 23:40hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM

.
"The Gracey HYPO-thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 28 February 2008

.
HOW does a VACCINE CREATE a DIABETIC if DISTRESS can CAUSE TYPE 1A DIABETES WITHOUT a VACCINE?
.
www.DiabetesHealth.cOM/read/1995/05/01/350.html {Distress}
www.tinyurl.cOM/2th7np {Courage}
.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.28.FEB.2008 @ 19:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 29 February 2008

.
BROWN & STENGER are INNOCENT until a Court decides if suggestion of BROWN & STENGER 'Robin Hood' {www.tinyurl.com/3xcgy7} support for revolutionary CURE for T1A diabetes ... unapproved JDRF ... is actually TRUE ?

Why were They fired c/o 'email rumor'(?) OR were BROWN & STENGER opposed, in good conscience, to the ongoing JDRF advice, since 2005(?), to deliberately 'OVER-dose' T1 Diabetics on Non-Human Insulin "NHI" to 'vaccinate-away'
{www.tinyurl.com/3bqcm9} any remaining natural Beta-Cell Insulin & C-peptide SECRETION ?


BROWN & STENGER 'Defendants Evidence' ...

> 0905 www.tinyurl.com/2d6d9s {JDRF 'advice' ~ "...Even though you may not need insulin, some doctors prefer that you take small doses of insulin daily throughout the honeymoon period..." = MINIMIZES natural BCI & BCC-peptide SECRETION}

> 0180 www.tinyurl.com/3xtff9 {T Deckert ~ Good guidance of T1A = more natural BCI & BCC-peptide SECRETION}

> 0178 www.tinyurl.com/2krkv3 {T Deckert ~ MINIMIZING Non-Human INSULIN dosage = MAXIMIZES natural BCI & BCC-peptide SECRETION}



HOW to MEASURE how much protective GLUCOSE INSULIN RESISTANCE "GIR" is available to HELP reduce RELATIVE HYPOglycemia Distress "RHOD" and thereby encourage natural Beta-Cell Insulin "BCI" production / Beta-Cell C-peptide "BCC" production / Beta-Cell reactivation/regeneration?


> 0208 www.tinyurl.com/2vygps {Sonia.Caprio@yale.edu ~ methodology of measuring GIR which increases the metabolic FITNESS of a Person to help supply glucose fuel to insulin-INDependent tissues including the BRAIN, SPINAL CORD & HEART}

> 0907 www.tinyurl.com/2ah8ek {Austin Larson @ www.tinyurl.com/2ov7dq ~ Big / big hearted Humans adaptively evolve with increased GIR to help supply glucose fuel to insulin-INDependent tissues; and also adapt with increased growth of blood vessels in organs such as the EYES & HEART to improve the efficiency of supply of oxygen EG bigger HEARTS help pump more blood with less beats per minute}.


.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.29.FEB.2008 @ 13:42hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 1 March 2008

.
WHY are the JDRF always INNOCENT of HELPING support T2 diabetes in CHILDREN of T1 Diabetic Moms?


WHAT WILL A COURT DECIDE if 'Robin Hood' {www.tinyurl.com/3xcgy7} BROWN & STENGER are INNOCENT and were really providing 'extra' support for T2 diabetes in Children born c/o a T1 Diabetic Parent?


HOW COULD THEY have believed that T2 Diabetic 'C-peptide-rich' Children have such a profound T2 genetic advantage ... that 'thrifty T1 gene' pregnancies are increasingly favoring the 'less thrifty T2 gene' Children(?) ... maybe because if Mom was a T1 Diabetic ... You REALLY could be a 'mis-diagnosed' T2 Diabetic {www.tinyurl.com/2arzxs}, just like Halle Berry(?), as suggested by Schnitzer & Tubiana {www.tinyurl.com/yrhksm} ... well before BROWN & STENGER were dismissed RE the "email rumor"(?).



new ... BROWN & STENGER 'Defendants Evidence' {to add to: www.tinyurl.com/3cesvf}...


> 0208 www.tinyurl.com/27xjlm {Tine.Dalsgaard.Clausen@dadlnet.dk ~ In Children of T1 Diabetic, primarily Caucasian Moms, the risk of T2 diabetes/pre-diabetes was significantly associated with elevated maternal blood glucose in late pregnancy}

http://www.DiabetesHealth.com/read/2008/02/26/5664.html {Patrick Totty ~ "...Moms' Type 1 or Pregnancy-Related Diabetes Increases Offsprings' Prospects for Type 2 ... A study at Copenhagen University Hospital in Denmark says there is a link between type 1 or pregnancy-related diabetes in mothers and the later onset of type 2 diabetes in their children..."}

http://www.DiabetesHealth.com/read/2007/11/02/5548.html {Linda von Wartburg ~ "...Halle Berry Says She's Worked Her Way Up From Type 1 to Type 2 Diabetes ... She says, 'I've managed to wean myself off insulin, so now I like to put myself in the type 2 category.'..."}



WHEN were ALL DIABETICS INNOCENT?

.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.01.MAR.2008 @ 13:23hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 2 March 2008

.
www.tinyurl.com/2u8hsz ...
.
BROWN & STENGER are 'INNOCENT' until a Court declares otherwise and subject to their 'right of appeal' ... BROWN & STENGER are INNOCENT and personally responsible for their own actions, and are personally responsible for the consequences of those actions. That should absolutely thrill you to hear that.

When You & the JDRF make judgments upon BROWN & STENGER ... what is your evidence that BROWN & STENGER are not INNOCENT and what is your evidence that BROWN & STENGER did not secretly demand that Frederick Banting's 1925 guidance be followed in preference to that of the JDRF published since at least 2005?

> 0905 www.tinyurl.com/2d6d9s {JDRF 'advice / guidance' ~ "...Even though you may not need insulin, some doctors prefer that you take small doses of insulin daily throughout the honeymoon period..."}



Part 3 of the new EVIDENCE matrix trilogy 'before FAIR trial & judgment' of BROWN & STENGER aka 'Defendants Evidence' {to add to: Part 1: www.tinyurl.com/3cesvf & Part 2: www.tinyurl.com/39ehq2} ...

Nobel Lecture, Frederick G. Banting, September 15, 1925 {www.tinyurl.com/2xrb8n & www.tinyurl.com/24eqyo} ...

'...Regardless of the severity of the 'T1A diabetes', it has been found that by carefully adjusting the diet and the dose of insulin, 'ALL Diabetics' may be maintained sugar-free. Since this is possible, it is to be strongly advocated, because we have abundant evidence for the belief that there is regeneration of the islet cells of the pancreas when the strain thrown upon them by a high blood sugar is relieved. The increase in tolerance is evidenced by the decreasing-dosage of artificially administered insulin. In fact, in some moderately severe cases, the tolerance has increased sufficiently that they no longer require insulin...'

OR

LoveDiabetes.com Lecture ... Sunday, 02 March, 2008 {www.tinyurl.com/ywmoyn} ...

"...when the natural 'down-regulation' adaptations {www.tinyurl.com/2po68s} thrown upon them by dehydration {www.tinyurl.com/ypozqv} and Relative HYPOglycemia Distress 'RHOD' {www.tinyurl.com/2uxb99} is relieved. The increase in tolerance is evidenced by the decreasing-dosage of artificially administered insulin. In fact, in some moderately severe cases, the tolerance has increased sufficiently that they no longer require insulin; [aka 'CURED'].




... If You really & truly CARE about truth & justice & Fred Banting's guidance for a CURE of all T1A Diabetics [easier NOW than then (?)] ... PLEASE start asking the JDRF some reasonable QUESTIONS with a genuine desire for reasonable ANSWERS ... before judging BROWN & STENGER without ANY reasonable evidence / trial / Jury / judgment / sentencing / parole [aka explanation / understanding / FORGIVENESS].



.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.02.MAR.2008 @ 22:14hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 3 March 2008

.
C-peptide as a Mediator of ARTERIAL STRENGTHENING in Early Diabetes - A Novel HYPO-thesis.

Trends Cardiovasc Med. 2008 Feb;18(2):67-71.Links

> 0208 www.tinyurl.com/2yr8u3 {Nikolaus.Marx@uniklinik-ulm.de}

Department of Internal Medicine II-Cardiology, University of Ulm, Germany.

Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of ARTERIAL STRENGTHENING. Various factors such as ADAPTIVE INCREASES IN BLOOD PRESSURE, INCREASED CHOLESTEROL FUELING, and a proinflammatory and prothrombotic state contribute to ARTERIAL STRENGTHENING in this HIGHLY-EVOLVED population, but the physioLOGICAL mechanisms leading to this characteristic pattern remain largely unexplored. Recent data suggest that the proinsulin cleavage product C-peptide could play a causal role in ARTERIAL REPAIR & STRENGTHENING by promoting monocyte and CD4-positive lymphocyte recruitment in early ARTERIAL STRENGTHENING and by inducing the proliferation of vascular smooth muscle cells. The review ATTEMPTS TO summarize the effects of C-peptide in vascular cells and discuss the potential relevance of such C-peptide effects on ARTERIAL STRENGTHENING in Diabetic Patients.

.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.03.MAR.2008 @ 22:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 4 March 2008

.
TEA mimics INSULIN ... SUP / SIP your way to HYPO-GLYCEMIA ?


Aging Cell. 2008 Jan;7(1):69-77. Epub 2007 Dec 19.


Black tea polyphenols ... MIMIC ... insulin / insulin-like growth factor-1 signalling to the longevity factor FOXO1a.


Cameron AR, Anton S, Melville L, Houston NP, Dayal S, McDougall GJ, Stewart D, Rena G.

Neuro-sciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.


> 0208 www.tinyurl.com/2naw2z {G.Rena@Dundee.ac.uk ~ IMPORTANCE of hepatic GLUCO-NEOGENESIS}


In vertebrates and invertebrates, relationships between diet and health are controlled by a conserved signalling pathway responsive to insulin-like ligands.

In invertebrate models for example, forkhead transcription factor family O (FOXO) transcription factors in this pathway regulate the rate of aging in response to dietary cues, and in vertebrates, ... age-induced deficits in the same pathway are thought to contribute to DYS-REGULATION of hepatic GLUCO-NEOGENESIS through genes such as phosphoenolpyruvate carboxykinase (PEPCK).

Recently = SCREENING for dietary constituents capable of regulating this pathway in A cell culture model.

3 black TEA 'theaflavins' ... theaflavin 3-O-gallate ... theaflavin 3'-O-gallate ... theaflavin 3,3'di-O-gallate and ... thearubigins ARE novel mimics of INSULIN and/or IGF-1 action on mammalian FOXO1a, PEPCK and moreover THERE IS EVIDENCE that the effects on this pathway of the green tea constituent (-)-epigallocatechin gallate depend on its ability to be converted into these larger structures.


With the exception of WATer, tea is the most popular drink globally, but despite this, little is known about the biological availability of black tea polyphenols in vivo or the molecular target(s) mediating the effects OF A ... HYPO-GLYCEMIA / HYPER-GLYCEMIA 'INSULIN-TEA' INDUCED 'ROLLER-COASTER'.


Further investigation in these two areas might provide insight into how HYPO-GLYCEMIA RELATED metabolic disease may be deferred.



"T for 2" (low?)


.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.04.MAR.2008 @ 22:32hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 5 March 2008

.
EVERY-ONE IS A 'DIABETIC' and prone to MACULAR DEGENERATION aka RETINOPATHY ... EXCEPT the

lucky UN-DRUG-TREATED DIABETICS or Those INTERMITTENT-FASTING protected by C-PEPTIDE,

GLUCOSE INSULIN RESISTANCE "GIR" and TRANSIENT SUPERNORMAL GLYCEMIA "TSG" ...


Juvenile Macular Degeneration = Retinopathy = Diabetes Diagnostic Criteria = ?
http://en.wikipedia.org/wiki/Macular_degeneration#Juvenile_macular_degeneration


Lancet. 2008 Mar 1;371(9614):736-43.

Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based

cross-sectional studies...


> 0308 www.tinyurl.com/2qtooe ~ TWong@unimelb.edu.au


Wong TY, Liew G, Tapp RJ, Schmidt MI, Wang JJ, Mitchell P, Klein R, Klein BE, Zimmet P, Shaw J. @ Centre for

Eye Research Australia, University of Melbourne, VIC, Australia.


BACKGROUND: The WHO and American Diabetes Association criteria for diagnosing diabetes mellitus

ASSUME the presence of a glycemic threshold for identifying retinopathy based on data from 3 previous studies

that had important limitations in detecting retinopathy...

In the Blue Mountains Eye Study, retinopathy prevalence was around 10% even at fasting plasma glucose

concentrations below 5.6 mmol/L (100 mg/dL) -- the current definition of normal -- and increased further at

concentrations beyond about 6.3 mmol/L (115 mg/dL), the researchers noted.

In the Australian Diabetes study, retinopathy likewise occurred at a similar rate among patients with low fasting

plasma glucose concentrations as in the overall cohort. Prevalence increased above 7.1 to 7.8 mmol/L (128 to

140 mg/dL) but for moderate retinopathy there was no suggestion of a threshold.

The Multi-Ethnic Study of Atherosclerosis showed the same pattern of prevalence at low fasting plasma glucose

levels but there was no threshold for retinopathy overall or for moderate cases.

Putting the three studies together, 7.4% to 13.4% of participants had retinopathy at glucose levels below 5.6

mmol/L (100 mg/dL).

Earlier studies had suggested that retinopathy was uncommon, at only 2% to 4% prevalence, among patients

whose fasting plasma glucose was below 5.6 (100 mg/dL).

In the combined studies, prevalence of retinopathy was 17.8% to 34.7% above the 7.0 mmol/L (126 mg/dL)

cutoff for a diagnosis of diabetes.

Whereas the earlier studies suggested a sensitivity of more than 80% for the diagnostic threshold of 7.0 mmol/L

(126 mg/dL), Dr. Wong's group found a low sensitivity of only 14.8% to 39.1% for the same cutoff.

INTERPRETATION: The current FPG cutoff of 7.0 mmol/L (125 mg/dL) used to diagnose diabetes did not

accurately identify people with and without retinopathy.


These findings suggest that EVERY-ONE IS A DIABETIC ?


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.05.MAR.2008 @

23:41hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 5 March 2008

.
EVERY-ONE IS A 'DIABETIC' and prone to MACULAR DEGENERATION aka RETINOPATHY ... EXCEPT the lucky UN-DRUG-TREATED DIABETICS or Those INTERMITTENT-FASTING protected by C-PEPTIDE, GLUCOSE INSULIN RESISTANCE "GIR" and TRANSIENT SUPERNORMAL GLYCEMIA "TSG" ...


Juvenile Macular Degeneration = Retinopathy = Diabetes Diagnostic Criteria = ?
http://en.wikipedia.org/wiki/Macular_degeneration#Juvenile_macular_degeneration


Lancet. 2008 Mar 1;371(9614):736-43.

Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies...


> 0308 www.tinyurl.com/2qtooe ~ TWong@unimelb.edu.au


Wong TY, Liew G, Tapp RJ, Schmidt MI, Wang JJ, Mitchell P, Klein R, Klein BE, Zimmet P, Shaw J. @ Centre for Eye Research Australia, University of Melbourne, VIC, Australia.


BACKGROUND: The WHO and American Diabetes Association criteria for diagnosing diabetes mellitus ASSUME the presence of a glycemic threshold for identifying retinopathy based on data from 3 previous studies that had important limitations in detecting retinopathy...

In the Blue Mountains Eye Study, retinopathy prevalence was around 10% even at fasting plasma glucose concentrations below 5.6 mmol/L (100 mg/dL) -- the current definition of normal -- and increased further at concentrations beyond about 6.3 mmol/L (115 mg/dL), the researchers noted.

In the Australian Diabetes study, retinopathy likewise occurred at a similar rate among patients with low fasting plasma glucose concentrations as in the overall cohort. Prevalence increased above 7.1 to 7.8 mmol/L (128 to 140 mg/dL) but for moderate retinopathy there was no suggestion of a threshold.

The Multi-Ethnic Study of Atherosclerosis showed the same pattern of prevalence at low fasting plasma glucose levels but there was no threshold for retinopathy overall or for moderate cases.

Putting the three studies together, 7.4% to 13.4% of participants had retinopathy at glucose levels below 5.6 mmol/L (100 mg/dL).

Earlier studies had suggested that retinopathy was uncommon, at only 2% to 4% prevalence, among patients whose fasting plasma glucose was below 5.6 (100 mg/dL).

In the combined studies, prevalence of retinopathy was 17.8% to 34.7% above the 7.0 mmol/L (126 mg/dL) cutoff for a diagnosis of diabetes.

Whereas the earlier studies suggested a sensitivity of more than 80% for the diagnostic threshold of 7.0 mmol/L (126 mg/dL), Dr. Wong's group found a low sensitivity of only 14.8% to 39.1% for the same cutoff.

INTERPRETATION: The current FPG cutoff of 7.0 mmol/L (125 mg/dL) used to diagnose diabetes did not accurately identify people with and without retinopathy.


These findings suggest that EVERY-ONE IS A DIABETIC ?


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.05.MAR.2008 @ 23:41hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 6 March 2008

.
IF YOU DRINK 'natural' TEA ... always add 'A SPOON-FULL of SUGAR' to every cup TO HELP PREVENT DIABETES?

MON.03.MAR.2008 {www.tinyurl.com/2naw2z} international press releases c/o Dr Graham Rena [of Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee] identifying new & substantial HYPOglycemia effectors which "mimic insulin" and are contained within TEA drinks [as published in "Aging Cell" (MAR.2008) 7, pp69-77].


?


IF YOU DRINK 'natural' TEA ... eat CAFFEINE or COFFEE on different days TO HELP PREVENT DIABETES?

More recently, on TUE.04.MAR.2008 {www.tinyurl.com/29cbot}, Dr Mark Hamer [of Department of Epidemiology and Public Health, University College London] has definitively associated 'dysglycemia' effects of both caffeine & tea and more-so ... a tea & caffeine combination factor [EG a 'pain-killer including a caffeine ingredient' taken with tea] 'combined dysglycemia effect' which may be sufficient to suggest that the combined HYPOglycemia effectors of tea & caffeine may even cause diabetes [probably as a 'chronic defense mechanism' against 'Relative HYPOglycemia Distress' (RHOD)].


?


www.YouTube.com/watch?v=Fz8dAlLSXzs

.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.06.MAR.2008 @ 22:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 7 March 2008

.
WHY should the JDRF sponsor this NOW?
.
CAREFULLY ALTER your DIETARY DIABETES PROTOCOL "DDP" to HELP MINIMIZE your INSULIN REQUIREMENT (?) in order to consciously help MAXIMIZE your Beta-Cell Insulin "BCI" production in response to Transient Supernormal Glycemia "TSG" which stimulates both BCI production and Beta-Cell C-peptide "BCC" production (?) ... and measure your YEARLY or QUARTERLY results ... with regular "STIMULATED C-PEPTIDE test" (?) ...

YOU GOTTA SEE THIS VIDEO !!!

www.NicholasDynesGracey.blogspot.cOM/2008_03_05_archive.html

YOU GOTTA SEE THAT VIDEO !!!


NB '...it has been found that by carefully adjusting the diet and the dose of insulin, 'ALL Diabetics' may be maintained sugar-free ...'


Nobel Lecture, Frederick G. Banting, September 15, 1925 {www.tinyurl.com/2xrb8n & www.tinyurl.com/24eqyo} '...Regardless of the severity of the 'T1A diabetes', it has been found that by carefully adjusting the diet and the dose of insulin, 'ALL Diabetics' may be maintained sugar-free. Since this is possible, it is to be strongly advocated, because we have abundant evidence for the belief that there is regeneration of the islet cells of the pancreas when the strain thrown upon them by a high blood sugar is relieved. The increase in tolerance is evidenced by the decreasing-dosage of artificially administered insulin. In fact, in some moderately severe cases, the tolerance has increased sufficiently that they no longer require insulin...'


OR


LoveDiabetes.cOM Lecture, Nicholas D. Gracey, Sunday, 02 March, 2008 {www.tinyurl.com/ywmoyn} ... "...when the natural 'down-regulation' adaptations {www.tinyurl.com/2po68s} thrown upon them by dehydration {www.tinyurl.com/ypozqv} and Relative HYPOglycemia Distress 'RHOD' {www.tinyurl.com/2uxb99} is relieved. The increase in tolerance is evidenced by the decreasing-dosage of artificially administered insulin. In fact, in some moderately severe cases, the tolerance has increased sufficiently that they no longer require insulin; [aka 'CURED']?..."


REFERENCES:-

> 0180 www.tinyurl.com/3xtff9 {T Deckert ~ Good guidance of T1A = more natural BCI & BCC-peptide SECRETION ~ '...T1 Diabetics (for 25+ years) with Beta-Cells secreting Insulin and C-peptide had significantly less severe retinopathy & nephropathy than T1 non-Secretors...'}

> 0178 www.tinyurl.com/2krkv3 {T Deckert ~ MINIMIZING Non-Human INSULIN dosage = MAXIMIZES natural BCI & BCC-peptide SECRETION ~ '...T1 Diabetics (for approx 31 years) with a low daily insulin requirement (less than 0.50 units/kg body weight) still have Beta-Cells secreting Insulin & C-peptide ... in 24% of the Patients. Severe retinopathy was lower in the Secretors than in the non-Secretor group...'}

.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.07.MAR.2008 @ 23:41hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 8 March 2008

.
WHY should the JDRF recognize George King's findings AND sponsor 'minimum insulin TO maximize C-peptide' NOW?
.
CAREFULLY ALTER your DIETARY DIABETES PROTOCOL "DDP" to HELP MINIMIZE your INSULIN REQUIREMENT (?) in order to consciously help MAXIMIZE your Beta-Cell Insulin "BCI" production in response to Transient Supernormal Glycemia "TSG" which stimulates both BCI production and Beta-Cell C-peptide "BCC" production (?) ... and measure your YEARLY or QUARTERLY results ... with regular "STIMULATED C-PEPTIDE test" (?) ...


NB '...it has been found that by carefully adjusting the diet and the dose of insulin, 'ALL Diabetics' may be maintained sugar-free ...'


1925 Fred Banting {www.tinyurl.com/2xrb8n & www.tinyurl.com/24eqyo} '...Regardless of the severity of the 'T1A diabetes', it has been found that by carefully adjusting the diet and the dose of insulin, 'ALL Diabetics' may be maintained sugar-free. Since this is possible, it is to be strongly advocated, because we have abundant evidence for the belief that there is regeneration of the islet cells of the pancreas when the strain thrown upon them by a high blood sugar is relieved. The increase in tolerance is evidenced by the decreasing-dosage of artificially administered insulin. In fact, in some moderately severe cases, the tolerance has increased sufficiently that they no longer require insulin...'

1978 Torsten Deckert {www.tinyurl.com/2krkv3} ~ MINIMIZING Non-Human INSULIN dosage = MAXIMIZES natural BCI & BCC-peptide SECRETION ~ '...T1 Diabetics (for approx 31 years) with a low daily insulin requirement (less than 0.50 units/kg body weight) still have Beta-Cells secreting Insulin & C-peptide ... in 24% of the Patients. Severe retinopathy was lower in the Secretors than in the non-Secretor group...'.

1987 Juan Grunwald {www.tinyurl.com/2d48d5} ~ conventional lowering of blood glucose, physiologically too fast, BENEATH kidney threshold CAUSES retinopathy.

2007 George King {www.tinyurl.com/2nr6b6} ~ insulin dose > retinopathy > Table 1.

2007 Halle Berry VIDEO {www.NicholasDynesGracey.blogspot.cOM/2008/03/how-may-sustainable-brain-glucose_07.html}

2008 George Eisenbarth {www.tinyurl.com/388dcb} ~ less insulin dose > less auto-immunity > more C-peptide ?

2008 "...when the natural 'down-regulation' adaptations {www.tinyurl.com/2po68s} thrown upon them by dehydration {www.tinyurl.com/ypozqv} and Relative HYPOglycemia Distress 'RHOD' {www.tinyurl.com/2uxb99} is relieved. The increase in tolerance is evidenced by the decreasing-dosage of artificially administered insulin. In fact, in some moderately severe cases, the tolerance has increased sufficiently that they no longer require insulin; [aka 'CURED']?..."


.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.08.MAR.2008 @ 23:45hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 9 March 2008

.
needful CHOLESTEROL = More Stress Resistance = LIFE or More ... HOW ?

video >

www.NicholasDynesGracey.blogspot.cOM/2008/03/cholesterol-more-stress-resistance-more.html

< video

MONitoring trends In CArdiovascular disease ? MONICA ... WHO ?


www.Love-Cholesterol.cOM


…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.09.MAR.2008 @ 17:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
"The Gracey HYPO=thesis" for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2hht4z
PREVENT ... Relative-HYPERglycemia-Distress (RHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... Relative-NormoGlycemia (RNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.Intermittent-Fasting.cOM
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/299t3f
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-Coma (HRDC)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODC) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is NOT a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 11 March 2008

.
Posted by Nicholas Dynes Gracey on 10 March 2008

.
Relative-HYPOglycemia-Distress = DIABETES ? ...HOW ?

video >

www.NicholasDynesGracey.blogspot.cOM/2008/03/relative-hypoglycemia-distressdiabetes.html

< video


Relative-HYPOglycemia-Distress "RHOD" causes DIABETES ? ...WHY ?



www.Relative-HYPOglycemia.cOM


.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.10.MAR.2008 @ 11:50hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 11 March 2008

.
DISTRESS causes HYPOglycemia RELATIVE to the Relative NORMOglycemia before that DISTRESS ? ...HOW ?


video >

www.NicholasDynesGracey.blogspot.cOM/2008/03/distress-causes-hypoglycemia-relative.html

< video


Relative HYPOglycemia persists if ... 'HYPOglycemia effectors' such as DISTRESS persists and/or HYPOglycemia FOOD administration persists and/or HYPOglycemia DRUG administration persists ... each/any 'HYPOglycemia effector' persisting ... irrespective of the INITIAL onset of HYPOglycemia relative to a previous Relative NORMOglycemia ... for any particular Individual at that particular time of their LIFE. Such a physiological state may reasonably be referred to as:-
Relative-HYPOglycemia-Distress "RHOD" ? ...WHY ?


www.DiabetesHealth.cOM/read/1995/05/01/350.html

www.TheDiabetesBlog.cOM/2007/05/25/tv-causes-elevated-glucose-in-children


.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.11.MAR.2008 @ 11:14hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 12 March 2008

.
Better DDP = Less INSULIN = Less HYPOglycemia ?
.
CAREFULLY ALTER your DIETARY DIABETES PROTOCOL "DDP" to HELP MINIMIZE your INSULIN REQUIREMENT (?) in order to consciously help MAXIMIZE your Beta-Cell Insulin "BCI" production in response to Transient Supernormal Glycemia "TSG" which stimulates both BCI production and Beta-Cell C-peptide "BCC" production (?) ... and measure your YEARLY or QUARTERLY results ... with regular "STIMULATED C-PEPTIDE test" (?) ...
.
GlucoNeoGenesis Cures HYPOglycemia ...HOW ?


GlucoNeoGenesis is the generation of glucose from non-sugar carbon substrates like pyruvate, lactate, glycerol, and glucogenic amino acids.

The vast majority of GlucoNeoGenesis takes place in the liver and, to a smaller extent, in the cortex of kidneys. This process occurs during periods of INTERMITTENT... fasting, starvation, or intense exercise and is highly endergonic.

GlucoNeoGenesis is often associated with ketosis.


video >

www.NicholasDynesGracey.blogspot.cOM/2008/03/gluconeogenesis-cures-hypoglycemia-how.html

< video



Hi AnyOne, also re HYPOglycemia-Distress ... WHAT DO YOU DO or WHAT SHOULD YOU DO or WHAT DO YOU SUGGEST FOR every day 'FITTENING' the HUMAN BODY'S CAPACITY for NATURAL GlucoNeoGenesis?



…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.12.MAR.2008 @ 12:23hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
.
'The Gracey HYPO=thesis' for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2hht4z
PREVENT ... Relative-HYPERglycemia-Distress (RHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... Relative-NormoGlycemia (RNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.Intermittent-Fasting.cOM
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/299t3f
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-Coma (HRDC)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODC) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is NOT a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN :)... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 13 March 2008

.
HOW much have You got in your 'BOTTLE of COURAGE' to change your understanding ...To Be or not To Be GlucoNeoGenic FIT ...HOW ?
.


video >

www.NicholasDynesGracey.blogspot.cOM/2008/03/to-be-or-not-to-be-gluconeogenic-fit.html

< video


The GlucoNeoGenic INHIBITING behavior illustrated above TREATS ... in a sometimes SUSTAINABLE, sometimes non-SUSTAINABLE way ... HYPOglycemia and/or treats, in a sometimes SUSTAINABLE, sometimes non-SUSTAINABLE way ... Relative-HYPOglycemia-Distress aka "RHOD" (?)



What GlucoNeoGenic behavior CURES ... in a substantially SUSTAINABLE way ... HYPOglycemia and/or cures in a substantially SUSTAINABLE way ... Relative-HYPOglycemia-Distress aka "RHOD" (?) and thereby avoids and/or PREVENTS the 'HYPOglycemia-STATES' ...WHY ?



BECAUSE an example of a 'HYPOglycemia-STATE' is a form of 'pre-diabetes' so barely distinguishable from 'pre-Type 1A' diabetes that One could reasonably suppose that the 'distress' referred to, way back in 1994/95, by Francine Kaufman as associated with CAUSING diabetes 'during an earthquake' ... may well amount to Relative-HYPOglycemia-Distress being the main avoidable CAUSE of T1A diabetes ...

EG ... "Autoimmune HYPOglycemia" aka pre-T1A diabetes ?

...Associated with the development of circulating anti-insulin antibodies as per T1A diabetes.

The development of anti-insulin antibodies has been reported in over 200 patients most of whom had medical issues with a gland, associated with DISTRESS adaption, called the "thyroid gland".

...The autoimmune HYPOglycemia is associated with eating and/or 'eating too OFTEN' and occurs 3-4 hours after meals following an initial post-prandial HYPERglycemic phase that is due to the antibodies interfering with the exit of insulin from the plasma to reach its target tissues. Later, after most of the meal is absorbed, inappropriate high levels of insulin dissociate from this antibody-bound compartment, resulting in HYPOglycemia. Insulin levels in excess of 1000 pmol/L are observed at time of HYPOglycemia, and these persons have high titers of insulin auto-antibodies aka pre-T1A diabetes (?) ... {so may this be an associated DISTRESS that leads to T1A diabetic 'HYPERglycemic compensation' (?)}.

Endocrinol Metab Clin North Am. 1999 Sep; 28(3): 603-18, vii.
Redmon JB, Nuttall FQ.

> 0999 www.tinyurl.cOM/3cr4ds {Redmo001@maroon.tc.umn.edu ~ Autoimmune HYPOglycemia}

Department of Medicine, University of Minnesota Medical School, Minneapolis, USA.




Hi AnyOne, also re HYPOglycemia-Distress ... WHAT DO YOU DO or WHAT SHOULD YOU DO or WHAT DO YOU SUGGEST FOR every day 'GlucoNeoGenic FITTENING' the HUMAN BODY'S CAPACITY for NATURAL GlucoNeoGenesis?

.
…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.13.MAR.2008 @ 11:27hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
.

Posted by Nicholas Dynes Gracey on 14 March 2008

.
T0, T1, T2, T3 & T4 DIABETICS with less Relative-HYPOglycemia-Distress & less bottled 'Vitamin Diabetes' ... SUSTAIN more C-peptide and BETTER micro-vascular health ?...
.
.
> 1006 www.tinyurl.cOM/yu4695 {JCVoltar@fmrp.usp.br ~ J.C. Voltarelli @ Universidade de São Paulo, Ribeirão Preto, SP, Brasil ... '...Secondary PREVENTION of T1 diabetes: reducing autoimmune 'Beta-Cell down-regulation' and promoting Beta-Cell Insulin "BCI" production & Beta-Cell C-peptide "BCC" production ?...'}
.
> 1207 www.tinyurl.cOM/ys7vkw {Matthias@liai.org ~ Matthias von Herrath @ La Jolla Institute for Allergy and Immunology, California 92037, USA ... '...T1 diabetes is a relapsing/remitting/REVERSIBLE disease ?...'}
.
> 0108 www.tinyurl.cOM/2thsjo {JCVoltar@fmrp.usp.br ~ J.C. Voltarelli @ Universidade de São Paulo, Ribeirão Preto, SP, Brasil ... '...T1 diabetes is associated with the autoimmune 'reduction' of the insulin-producing pancreatic Beta-Cells. This autoimmune 'Beta-Cell DOWN-REGULATION' may begin days, weeks, months or even years BEFORE the presentation of HYPERglycemia symptoms. At the time of clinical diagnosis, 'often' less than 30% of Beta-Cell mass still remains. The conventional therapeutic option to T1D is daily insulin injections ... Diabetics with less HYPOglycemia events sustained higher serum levels of C-peptide and suffered less micro-vascular complications over the subsequent years ... In face of this, preservation/up-regulation [www.tinyurl.cOM/2j5hmm] of Beta-Cell insulin production & Beta-Cell C-peptide production is an important target in the management of T1D and its related complications ?...'}
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Diabetes is NOT a disease ... www.tinyurl.cOM/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.cOM/36qxn3
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> 0192 www.tinyurl.cOM/2vp36k {Robert.Cohen@uc.edu @ University of Cincinnati Medical Center, Ohio, USA ... '...HYPOglycemia with HYPERinsulinemia ... following CALCITRIOL [www.tinyurl.cOM/2hpzxp] = VITAMIN 'D' [a steroid hormone precursor] which is associated with inducing HYPOglycemia [and associated down-regulation of insulin gene expression (www.tinyurl.com/2cgavg)] and CALCITRIOL aka 'Vitamin Diabetes' may induce Relative-HYPOglycemia-Distress (RHOD) by masking protective HYPERglycemia and may also lead, in some countries, to reductions in diagnosis of T1D and an associated increased incidence of Neuro-Psychiatric-Illness [www.Relative-HYPOglycemia.cOM] ?...'}
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Every Day Better In Every Way ...HOW ?

> video

www.NicholasDynesGracey.blogspot.com/2008/03/every-day-better-in-every-way-how2.html

< video
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.14.MAR.2008 @ 09:33hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 15 March 2008

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What's in your 'bottle of Soy' ... THYROID gland shiver and sweat and SHAKERS ?
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> 0500 www.tinyurl.cOM/3d6yg8 {Kathleen McCormick @ McCormick Communications ~ '... Dr Broda O Barnes ... on shiver and sweat and shakers and changes in temperature and possible associations to questioning what defines a food-allergy AND asks what is the main thyroid / diabetes link ?...'}.

> 0777 www.tinyurl.cOM/yu3xx9 {Marie-Claude Giess @ Centre National da la Recerche Scientific, Laboratoire de Pharmacologie et Toxicologie Fondamentales, Toulouse, France ~ '...Ageing in Drosophilia is modified according to their physiological state. Adult longevity is decreased by sexual activity: in both sexes the life span of virgins is higher. For the same physiological state male longevity is always lower than that of females ...'}
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> video

www.NicholasDynesGracey.blogspot.cOM/2008/03/celibating-shaker-celibating-celibator.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.15.MAR.2008 @ 22:32hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 16 March 2008

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TIME for Training your ALPHA cells ...HOW ?
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www.GLUCAGON.cOM
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> video

www.NicholasDynesGracey.blogspot.cOM/2008/03/time-for-training-your-alpha-cells-how.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.16.MAR.2008 @ 22:15hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 17 March 2008

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WHO is responsible for the DOSE of WHAT is prescribed from within an INSULIN bottle (?) ... and ... Hippocratic Oath like RESPONSIBILITY lies with Every Licensed Physician to act as a FILTER between FREE ENTERPRISE and Patients' long term health ...HOW?
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The Hippocratic Oath says: "...To please no one will I prescribe a deadly drug nor give advice which may cause his death..."
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> 0107 www.aapsonline.org/ethics/oaths.htm [AAPSonline.org]
... 2006 www.tinyurl.com/2gtyp4 [Roy_Poses@Brown.EDU]
www.en.wikipedia.org/wiki/Euthanasia
> 0950 www.tinyurl.com/345uzh [TIME.com]
... 2007 www.tinyurl.com/3xv8y2 [lsn@lifesite.net]
> 0407 www.tinyurl.com/2dad25 [Kauffman@hslc.org]
... 2007 www.tinyurl.com/2jphjr [Rob.Butler@uhns.nhs.uk]
... 2007 www.tinyurl.com/2c3yj8 [Malcolm@llp.org.uk]
> 0107 www.tinyurl.com/2tt8ho [healthexpert]
> 0107 www.tinyurl.com/2jlt7v [funniinnit]
... 2007 www.tinyurl.com/yqmqnj [Kauffman@hslc.org]
... 2006 www.tinyurl.com/nx2bk [BBC.co.uk]
> 0103 www.thincs.org [Ravnskov@tele2.se]
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www.NicholasDynesGracey.blogspot.cOM/2008/03/hippocratic-oath-like-responsibility.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.17.MAR.2008 @ 23:34hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 18 March 2008

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What is GLUCAGONIC and INSULINIC training ...HOW ?
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Glucagonic activity Cures HYPOglycemia & Relative HYPOglycemia Distress "RHOD" ...HOW ?
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Glucagonic activity is the release of endogenous glucose from glycogen stores including the brain & liver and the generation of 'new glucose' from non-sugar carbon substrates like pyruvate, lactate, glycerol, and glucogenic amino acids.

The vast majority of Glucagonic activity takes place in the liver and, to a smaller extent, in the cortex of kidneys. This Glucagonic process occurs during periods of INTERMITTENT... fasting, starvation, or intense exercise and is highly endergonic.

Glucagonic activity is often associated with ketosis.
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Insulin inhibits Glucagonic activity.


video >

www.NicholasDynesGracey.blogspot.cOM/2008/03/what-is-glucagonic-and-insulinic.html

< video



Hi AnyOne, also re HYPOglycemia-Distress ... WHAT DO YOU DO or WHAT SHOULD YOU DO or WHAT DO YOU SUGGEST FOR every day 'FITTENING' the HUMAN BODY'S CAPACITY for NATURAL GlucoNeoGenesis ?



…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.18.MAR.2008 @ 12:40hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
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'The Gracey HYPO=thesis' for the CAUSE & CURE of diabetes... www.1MealEveryDay.cOM
CURE auto-immunity [100pc Fresh Organic Raw Liquidiet]... www.LIQUIDarian.cOM
CURE diabetes... www.tinyurl.com/2guhfd CURED diabetes ... www.tinyurl.com/yno298
PREVENT ... HYPOglycemia-Unawareness (HOU)... www.tinyurl.com/2hht4z
PREVENT ... Relative-HYPERglycemia-Distress (RHRD)... www.tinyurl.com/ynpp4g
PROVIDE ... Relative-NormoGlycemia (RNG)... www.tinyurl.com/3bcn7j
Eat not less but less OFTEN... www.Intermittent-Fasting.cOM
Eating less OFTEN is profoundly more healthy than eating less... www.tinyurl.com/299t3f
Eating too OFTEN sustains & CAUSES all diabetes... www.tinyurl.com/2j7p3t
PROTECT from HYPERglycemia-Dehydration-Coma (HRDC)... www.tinyurl.com/2mcyx6 &
...from HYPOglycemia-Distress-coma (HODC) ... FOR Liquidiet... www.tinyurl.com/2ohk2a
Diabetes is NOT a disease ... www.tinyurl.com/2uxb99 ... diabetes is the CURE...
...for ... Relative-HYPOglycemia-Distress (RHOD)... www.tinyurl.com/36qxn3
Eating-less-OFTEN-Fasting-more-OFTEN-Loving-more-OFTEN ... www.CELIBATOR.cOM
http://www.DiabetesHealth.cOM/read/2007/11/29/5564.html#comments
AdrenaLINE... www.1MealPerDay.cOM ..."Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 19 March 2008

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Reversal Of Pancreatic Alzheimers Type 1 or Type 2 ...HOW ?
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video >

www.NicholasDynesGracey.blogspot.cOM/2008/03/reversal-of-pancreatic-alzheimers-how.html

< video



…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.19.MAR.2008 @ 21:25hrs c/o www.LoveDiabetes.cOM & www.HYPO-thesis.cOM
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Posted by Nicholas Dynes Gracey on 20 March 2008

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Distress > HYPERthyroid > HYPOglycemia > Diabetes or ... Reversal ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.cOM/2008/03/hyperthyroid-hypoglycemia-diabetes-how.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.20.MAR.2008 @ 21:33hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 21 March 2008

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Why SOy should be fermented and organic ONLY eg Miso / Natto / Shoyu / Tempeh ... and thyroxin-diabetes inter-actions ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.cOM/2008/03/why-soy-should-be-fermented-and-organic.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.21.MAR.2008 @ 23:23hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 22 March 2008

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Puberty brings 100% Responsibility for Actions ... and diabetes is a LIFEstyle choice too ? ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.cOM/2008/03/puberty-responsibility-for-actions.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.22.MAR.2008 @ 23:34hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 23 March 2008

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Jonathan Livingston Seagulls LOVE and what is LOVE-diabetes and ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.cOM/2008/03/jonathan-livingston-seagulls-love-how.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.23.MAR.2008 @ 23:45hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "Lovingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 24 March 2008

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LOVEingly Every decisecond Better GroundHog-Day and Jonathan Livingston Seagulls LOVE explains why LOVE-diabetes and the CURE and ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.cOM/2008/03/loveingly-every-decisecond-better.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.24.MAR.2008 @ 23:24hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 25 March 2008

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fda HYPO-allergic reaction choice now or HYPER-allergic LIFEstyle - You choose your LIVER reaction and see what LOVE-diabetes really is ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.com/2008/03/fda-hypo-allergic-reaction-choice-now.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.25.MAR.2008 @ 19:19hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-OrMore"
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Posted by Nicholas Dynes Gracey on 26 March 2008

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fda HYPO-intolerant reaction choice now or HYPER-intolerant LIFEstyle - You choose your LIVER reaction and see what LOVE-diabetes really is ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.com/2008/03/fda-hypo-intolerant-reaction-choice-now.html

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Eating less OFTEN is profoundly more healthy than eating less...
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> 0400 www.tinyurl.cOM/2j7p3t [DFadool@neuro.fsu.edu]
> 0501 www.tinyurl.cOM/yqf8gj [Maeda@ys7.u-shizuoka-ken.ac.jp]
> 0503 www.tinyurl.cOM/ys63gk [Anson@jhu.edu]
> 0407 www.tinyurl.cOM/29kvda [ZangenD@hadassah.org.il]
> 1007 www.tinyurl.cOM/3aypqg [MRistow@mristow.org]
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Glucose / insulin "resistance" arises in at least 2 forms: (A) Insulin receptors which adaptively reduce their functional efficiency of 'pumping' glucose into cells; and (B) Insulin receptors that 'disappear' from cells. Why do You think there is just 1 name, in common use, to describe more than 2, vitally different, physiologies?? Type 1 & type 2 Diabetic ... glucose / insulin 'resistance' arises primarily via insulin receptors which adaptively down-regulate their rate of 'pumping' glucose into fat / liver / muscle cells ... so that more glucose is diverted/available for the brain / nervous system.

http://tinyurl.com/3aypqg [mristow@mristow.org]

Type 3 Diabetic ... glucose / insulin 'resistance' arises primarily via insulin receptors that 'disappear', from nerve cells, BECAUSE eating too OFTEN results in 'cycles' of localised brain / nerve damage & 'sclerosis scarring' [eg called 'Alzheimers' & 'peripheral neuropathy' ] via "relative-HYPOglycemia" ... which subsequently results in localised brain/nerve starvation c/o the 'glucose-starved HYPOglycemia', primary stage, followed by localised brain/nerve destruction during the "relative-HYPERglycemia", secondary stage, also called 'glucose re-perfusion'.

http://tinyurl.com/ynpp4g [raymond.swanson@ucsf.edu]

... In the absence of adaptative [protective] type 3 Diabetic glucose / insulin 'resistance' [aka brain-insulin receptor down-regulation] ... too OFTEN meal-induced 'glucose re-perfusion', via highly efficient nerve-insulin receptors, could induce massive neural damage relatively quickly [cf. youth-onset neuropathy].

http://tinyurl.com/yuh3q8 [mattisonj@mail.nih.gov]

Type 3 diabetes Is Caused By Food And Or Drug Administration Too Much And Or Too Often.

http://tinyurl.com/yta44e [giulio.passinetti@mssm.edu]

Pancreatic-insulin or 'digestion-insulin' [primarily for STORING glucose in fat, liver & muscle cells] for FUTURE use by the brain & nervous system] is usually produced by beta-cells following a period of eating. Brain-insulin or 'nerve-insulin' [primarily for CURRENT use to help with REGULATING glucose feeding into the nervous system] is produced by 'nerve cells' following a suitable period of sleep/eating less OFTEN.

http://www.tinyurl.com/2j7p3t [dfadool@neuro.fsu.edu]

Eating less OFTEN increases the number of brain-insulin receptors, increases the availability of glucose to the brain, reduces appetite and increases the availability of ketone fuel for the brain.

http://tinyurl.com/ys63gk [anson@jhu.edu]

Eating too often decreases the number of brain-insulin receptors, reduces the availability of glucose to the brain, increases appetite and reduces the availability of ketone fuel for the brain.

http://tinyurl.com/26jy4l [jens.bruening@uni-koeln.de]

Eating less is profoundly different from eating less OFTEN.

http://tinyurl.com/323nj3 [froelich@em.uni-frankfurt.de]

Blood glucose feeds the brain efficiently in the absence of any pancreatic-insulin because in the absence of food [ie following a sufficient period of sleep/fasting] the brain-insulin production is increased to help 'pump' the relatively lower levels of blood glucose into the nerves eg into the brain via brain-insulin receptors.

http://www.tinyurl.com/yr48jq [freychet@unice.fr]

Type 1, 2 or 3 Diabetes is NOT a disease [it is the associated 'HYPOglycemia' that is the 'disease'] ... type 1 & type 2 diabetes aka HYPERglycemia [that can exist for years] is a 'physiological body state' that protects the nervous system [especially the brain] from the extraordinary dangers of beta-cell and/or HYPERinsulinemia [excess insulin] associated "relative-HYPOglycemia" [which starves the nervous system of fuel and can result in profound challenges within minutes, or even seconds, with little or zero notice].

http://tinyurl.com/yu77y7 [m.henricsson@telia.com]

Type 1, 2 or 3 diabetes is NOT a disease … Type 1, 2 or 3 diabetes is the CURE [for relative-HYPOglycemia].

http://www.tinyurl.com/yqf8gj [maeda@ys7.u-shizuoka-ken.ac.jp]

'Relative-HYPOglycemia As A Cause Of Neuropsychiatric Illness' @ Journal Of The National Medical Association @ Harry M Salzer MD @ January 1966 @ Vol 58 @ Number 1 @ Table 1 @ Figure 2.In my opinion UNdrugTREATED type 2 diabetes [aka "cellular dietary restriction"] is a protective adaptative response which, by means of protecting the brain from "relative-HYPOglycemia", can be expected to reduce or eliminate type 3 diabetes aka 'Alzheimers'.

http://tinyurl.com/2farm9 [temorgan@usc.edu]

Please ask your current Specialist for advice including the provision of supporting Peer reviewed references evidencing their understanding of this important matter.

http://tinyurl.com/2lwbro [DrBernarr@aol.com]
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.26.MAR.2008 @ 23:32hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVE-ingly-I-Fast-Every-23hrs-45mins-Or-More"
.

Posted by Nicholas Dynes Gracey on 27 March 2008

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Why LOVE cholesterol and LOVE diabetes ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.com/2008/03/why-love-cholesterol-and-love-diabetes.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.27.MAR.2008 @ 23:25hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVE-ingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 28 March 2008

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Body Earth GIA Glucose Insulin Amylin ...HOW shocking ?
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> video

www.NicholasDynesGracey.blogspot.com/2008/03//body-earth-gia-glucose-insulin-amylin.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.28.MAR.2008 @ 23:50hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVE-ingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 29 March 2008

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Puberty chosen Intent chosen Direction chosen Diabetes ...HOW ?
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www.NicholasDynesGracey.blogspot.com/2008/03/puberty-chosen-intent-chosen-direction.html

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IS 'SEX' WITHOUT-INTENT-TO-PROCREATE SUSTAINING' DIABETIC' TYPE HYPERGLYCEMIA BY CHRONIC LOSS OF ZINC-CONTAINING SEXUAL FLUIDS?

'CELIBATING' for natural PROTECTION & more stable BLOOD GLUCOSE?

> 0777 www.tinyurl.com/yu3xx9 {Ageing in Drosophilia is modified according to their physiological state. Adult longevity is decreased by sexual activity: in both sexes the life span of virgins is higher. For the same physiological state male longevity is always lower than that of females.}

> 0896 www.tinyurl.com/3b5hsr {Gisela.Dahlquist@pediatri.umu.se ~ Zinc deficiency has shown to increase the risk for diabetes in diabetes-prone experimental animals.}

> 0208 www.tinyurl.com/2dmqk8 {Ian.MrTao@Gmail.com ~ naked PROTECTION}

> 0407 www.tinyurl.com/2odhdo {Masturbation video illustrating extreme sexual fluid loss and concomitant potential ZINC deficit induced alpha-cell HYPERglycemia -- There is a different outcome between alpha-cell glucagon ... stimulated relative-HYPERglycemia [EG a horror movie (www.tinyurl.com/2opc5h)] ~ VS ~ eating too OFTEN ... caused acute relative-HYPERglycemia [EG a cake (www.tinyurl.com/32dvnb) and a combination of both in the form of LOSS of sexual fluids as per the referenced video about masturbation.}

> 0407 www.tinyurl.com/2oonjv {'...We propose that during HYPOglycemia the principal signal that initiates glucagon secretion is the detection by alpha-cells of a sudden decrease in ZINC ... stimulates glucagon secretion.'}

> 0108 www.tinyurl.com/yrd6u {Alpha-cells & Epsilon-cells (www.tinyurl.com/2psoy3) secrete ghrelin which inhibits beta-cell insulin release & stimulates growth hormone release from the anterior pituitary (www.tinyurl.com/3exose) AND alpha-cells secrete glucagon which stimulates glucose production in / release from ... the LIVER ... into the blood.}

> 1007 www.tinyurl.com/2jknrw {Ian Clark ~ CELIBATING ~ Brotherhood & Sisterhood}

> 0108 www.tinyurl.com/38c2ek {"...For the record, I am a practcing Catholic who waited until sex for marriage...unlike Ms. Berry. And yet she is "cured" and not me...go figure..."}

> 0208 www.tinyurl.com/24sls8 {continent ~ VS ~ incontinent ... Masturbation causes BOTH females & males much loss of sexual fluids ... but this article highlights the female potential to actively absorb the male fluids which may hint at potential reason for female / male differences in lifespan.

> 0807 www.tinyurl.com/238xfv {Ian Clark ~ CELIBATING ~ Time}

> 0907 www.tinyurl.com/25qqvy {Ian.MrTao@Gmail.com ~ CELIBATING ~ Contraception / Zinc barrier / HPV}

HOW INCONTINENT SHOULD YOU BE?
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.29.MAR.2008 @ 23:37hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVE-ingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 30 March 2008

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WHAT is LOVE diabetes and Mindering Organization to do with healing and/or chronic HYPERglycemia ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.com/2008/03/what-is-love-diabetes-and-mindering-how.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.30.MAR.2008 @ 23:55hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVE-ingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 31 March 2008

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HYPOglycemia can invoke HYPERglycemia ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.com/2008/03/hypoglycemia-can-invoke-hyperglycemia.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.31.MAR.2008 @ 23:37hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVE-ingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 1 April 2008

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HYPERglycemia is the cure for HYPOglycemia ...HOW ?
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> video

www.NicholasDynesGracey.blogspot.com/2008/04/hyperglycemia-is-cure-for-hypoglycemia.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.01.APR.2008 @ 23:57hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 2 April 2008

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Human Rights to Learn and to Do even if You are lucky enough to have unDRUGtreated Glucose Insulin Resistance "GIR" ...HOW ?
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www.NicholasDynesGracey.blogspot.com/2008/04/human-rights-to-learn-and-to-do-how.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.02.APR.2008 @ 23:54hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 3 April 2008

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Hooked on High performance Sustainably or Non-Sustainably by your controlling-sugar or sugar-control controlling-sugar ...HOW?
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www.NicholasDynesGracey.blogspot.com/2008/04/hooked-on-high-performance-sustainably.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.03.APR.2008 @ 23:57hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 4 April 2008

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emf Wi-Fi distress induced HYPERglycemia ...HOW?
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www.NicholasDynesGracey.blogspot.com/2008/04/emf-wifi-distress-induced-hyperglycemia.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.04.APR.2008 @ 23:23hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 5 April 2008

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Fluctuations Fluctuations Fluctuations or Even Glucose (EG) and Transient Supernormal Glycemia (TSG) to help regenerate the pancreas ...HOW ?
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www.NicholasDynesGracey.blogspot.com/2008/04/fluctuations-fluctuations-flucuations.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.05.APR.2008 @ 23:17hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 6 April 2008

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Fit Fits Fitten Fitter Fittest Fitting Fittening glucagonic glycogenolysis and diabetes help prevent Relative-HYPOglycemia Distress (RHOD) ...HOW ?
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www.NicholasDynesGracey.blogspot.com/2008/04/fit-fitter-fittest-fitting-fittening.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.06.APR.2008 @ 22:33hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 7 April 2008

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Common Denominator HEALING vibration is what type of LOVE [positive / negative (?)] and ...HOW ?
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www.NicholasDynesGracey.blogspot.com/2008/04/common-denominator-healing-vibration.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.07.APR.2008 @ 23:32hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 8 April 2008

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CLOtherapy... moves Spinal Energy Upwards ... healing and regenerating organs above the groin including the pancreas ...HOW ?
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www.NicholasDynesGracey.blogspot.com/2008/04/clotherapy-moves-spinal-energy-upwards.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.08.APR.2008 @ 23:40hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 9 April 2008

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Intermittent Fasting 40 yard Cholesterol intense training builds healthy Heart muscle, BAT, HGH, pancreatic Alpha cells and Glucagon supply ...HOW ?
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www.NicholasDynesGracey.blogspot.com/2008/04/intermittent-fasting-40yard-cholesterol.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.09.APR.2008 @ 23:57hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 10 April 2008

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Ketone & Glucose Keep Heart Pumping and help protect Human hearts from HYPOglycemia associated Long QT Syndrome [LQTS]- including 'Diabetics' ...HOW ?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/ketone-and-glucose-keep-heart-pumping.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.10.APR.2008 @ 23:14hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 11 April 2008

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Why... Love-Cholesterol & Love-Diabetes ...HOW ?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/why-love-cholesterol-love-diabetes-how.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.11.APR.2008 @ 23:41hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 13 April 2008

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Posted by Nicholas Dynes Gracey on 12 April 2008
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Positive Health Energy Contraception or Transmutation up your Spinal cord for a healthier Pancreas [alpha & beta cells] and other Organs ...HOW ?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/positive-health-energy-contraception.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.12.APR.2008 @ 21:17hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 13 April 2008

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Love-HYPERtension, what is blood and when is raised blood pressure beneficial to Diabetics and EveryOne else ...HOW ?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/love-hypertension-what-is-blood.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.13.APR.2008 @ 17:57hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 14 April 2008

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Disease comes OUT of your mouth disease - as does allergic food intolerance, diabetes and all manner of other such dis-eases ...HOW?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/disease-comes-out-of-your-mouth-disease.html

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“Words from the Heart make wishes come true”

This is the power of prayers. This may appear to be a hyperbole but there is certainly more than an iota of truth in this statement. This statement is based on the premise that prayer has magical powers. However there is dispute over it because in this world of rationality, skepticism prevails large.

This disbelief or doubt is on account of two kinds of prayers that we do. One prayer comes from the vocal chords of the throat alone while the other comes right from the heart. A prayer is not a recitation of some set of words or sentences; it is a heartfelt expressed desire for whose accomplishment we look for divine intervention.

http://www.MindBodYnSoul.cOM/articles/Words_from_Heart_Make_a_Prayer.html
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.14.APR.2008 @ 21:00hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 15 April 2008

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Compensatory HYPERglycemia AKA 'diabetes' Protects the body from HYPOglycemia associated disease EG - Heart attacks, Schizophrenia & Epilepsy ...HOW ?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/compensatory-hyperglycemia-protects-how.html

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Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.


Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

The individual size of the beta-cells in the insulin-deficient fetuses was similar to controls, suggesting that the relative increase in islet size was due to an increase in cell number. Immunohistochemistry for proliferating cell nuclear antigen within the pancreatic ductal epithelium showed no differences in labeling index between insulin-deficient and control mice, and no change in the number of beta-cells associated with ducts, but the relative size distribution of the islets was altered so that fewer islets under 5,000 microm(2) and more islets greater than 10,000 microm(2) were present in Ins1-/-, Ins2-/- animals.

This suggests that the greater mean islet size seen in insulin-deficient animals represented an enlargement of formed islets and was not associated with an increase in islet neogenesis.

* The proportional contribution of alpha- and beta-cells to the islets was not altered.

This was supported by an increase in the number of cells containing immunoreactive proliferating cell nuclear antigen in both islet alpha- and beta-cells at E18.5 in insulin-deficient mice, and a significantly lower incidence of apoptotic cells, as determined by molecular histochemistry using the terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick end labeling reaction.

The density of blood vessels within sections of whole pancreas, or within islets, was determined by immunohistochemistry for the endothelial cell marker CD31 and was found to be increased 2-fold in insulin-deficient mice compared with controls at E18.5. However, no changes were found in the steady-state expression of mRNAs encoding vascular endothelial growth factor, its receptor Flk-1, IGF-I or -II, the IGF-I and insulin receptors, or insulin receptor substrates-1 or -2 in pancreata from Ins1-/-, Ins2-/- mice compared with Ins1-/-, Ins2+/- controls.

CONCLUSION ... The relative hyperplasia of the islets in late gestation in the insulin-deficient mice was due to an increased islet cell proliferation coupled with a reduced apoptosis, which may be related to an increased vascularization of the pancreas.

http://endo.endojournals.org/cgi/content/full/143/4/1530
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) TUE.15.APR.2008 @ 21:00hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 16 April 2008

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GlucaGOnic freedom from Carbophilia addiction ...HOW ?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/glucagonic-freedom-from-carbophilia.html

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Metabolic syndrome and low-carbohydrate ketogenic diets in the medical school biochemistry curriculum.

Feinman RD, Makowske M.

One of Robert Atkins contributions was to define a diet strategy in terms of an underlying metabolic principle ("the science behind Atkins"). The essential feature is that, by reducing insulin fluxes, lipids are funnelled away from storage and oxidized. Ketosis can be used as an indicator of lipolysis.

A metabolic advantage is also proposed: controlled carbohydrates leads to greater weight loss per calorie than other diets. Although the Atkins diet and its scientific rationale are intended for a popular audience, the overall features are consistent with current metabolic ideas.

The Atkins controlled-carbohydrate diet is used as a focal point for teaching nutrition and metabolism in the first-year medical school curriculum.

The topics that are developed include the role of insulin and glucagon in lipolysis, control of lipoprotein lipase, the glucose-glycogen-gluconeogenesis interrelations, carbohydrate-protein interactions and ketosis.

In essence, the approach is to expand the traditional feed-fast (post-absorptive) cycles to include the effect of low-carbohydrate meals: the disease states studied are generalized from traditional study of diabetes to include obesity and metabolic syndrome.

The ideal diet for weight loss and treatment of metabolic syndrome, if it exists, remains to be determined, but presenting metabolism in the context of questions raised by the Atkins regimen prepares future physicians for critical analysis of clinical and basic metabolic information.

http://www.ncbi.nlm.nih.gov/pubmed/18370662
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) WED.16.APR.2008 @ 23:23hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 17 April 2008

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HYPO-allergic or HYPER-allergic ... HYPO-glycemia or HYPER-glycemia ...HOW ?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/hypo-allergic-or-hyper-allergic-how.html

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EpiPens are commonly carried by persons with severe allergies and a risk of anaphylactic shock because they can be self-administered and are very fast-acting. In the UK and US, EpiPens are regulated medical devices and require a prescription. In Canada, EpiPens may be purchased without a prescription, but they are kept behind pharmacy counters.

The standard dosage of epinephrine supplied by an EpiPen is 0.3 ml of 1 in 1000 Parts (0.3 mg). Child-sized dosages (0.15 mg) are available as the EpiPen JR. In the US, EpiPen JR is recommended for children 33-66 lb.[1], while in Canada it is recommended for children 15 to 30kg. [2]

The EpiPen contains a spring-loaded needle that shoots through a membrane in the tip and into the recipient's body to deliver the medication.

EpiPen usually has a shelf life of 20 months, when the EpiPen should be discarded if unused, by returning it to a local pharmacy or hospital for safe disposal. Using an EpiPen that has expired is discouraged but better than nothing in an emergency.

The original carrying tube that the pen came in was easily broken; however, the manufacturer has recently begun shipping EpiPens in more durable carrying tubes with significantly thicker plastic walls, a screw top, and metal plating at the bottom (needle) end to prevent puncture injuries.

Despite being trademarked, common usage of the word "epipen" is drifting toward the generic context of any epinephrine autoinjector.

Instructions

EpiPens manufactured before December 2004 carried instructions for use stating that after the locking cap was removed, the device was put to the injection site and then pressure was applied to activate the mechanism.

All EpiPens manufactured since December 2004 carry a new version of the instructions, which are assumed to be more intuitive.[3] In the new instructions, approved by the Government’s Medicines and Healthcare products Regulatory Agency (UK), a patient uses the device by removing the gray locking cap from the top of the device, forming a fist around the unit, and jabbing it firmly into a thigh until the click of the spring-loaded needle activating is heard. Both sets of instructions are valid.

Regardless of the instruction version, after activation the patient holds the device in place for 10 seconds as the epinephrine is delivered. This gives the drug enough time to be absorbed by the body's muscles and diffused into the bloodstream. Using the device intravenously is highly discouraged, and can even be lethal as epinephrine is a local vascular constrictor, and use intravenously can restrict blood flow to the area of the injection site, causing subsequent damage to extremities. Additionally, intravenous administration of the EpiPen can cause ventricular tachycardia, or dangerously rapid heartbeat. [4] After administering the device, patients are advised to seek immediate medical attention. Directions for use of the injector are found on the device itself.

Alternatives

Companies other than Dey have begun to market similar devices, such as the Twinject. Ampules of epinephrine are also available for single use in physician offices and hospital pharmacies, as are preloaded Tubex cartridges. None of these devices prevents future episodes of anaphylaxis, but patients who experience severe or life-threatening reactions may be treated with a series of allergy injections composed of increasing concentrations of naturally occurring substances such as venom to provide excellent and usually life-long protections against adverse affects of future insect stings: these injections are astonishingly dilute—a billion-fold or more is common.

http://en.wikipedia.org/wiki/Epi-pen
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) THU.17.APR.2008 @ 19:50hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 18 April 2008

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Dysglycemia ... Dehydration ... Relative HYPOglycemia Distress ... Coma and/or Diabetes as Cure for lack of brain insulin ...HOW?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/daily-mail-25-mar-2008-page-32.html

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"...Hospital gave 'Order' to let our mother die, say Sisters...

AN ELDERLY woman was left to die in hospital after an order not to resuscitate her was issued without her family's knowledge, it was revealed yesterday.

The daughters of Doris Jarvis, 82, found the order on her medical file after complaining about the 'appalling and disgraceful' care they claimed she received.

The General Medical Council is investigating the case.

Shirley Ross, 54, and Alyson Jarvis, 51, said the Do Not Resuscitate order had been signed by a doctor but other sections, titled 'discussed with the patient/carer,' 'outcome of discussion' and 'nurse in charge' were blank and had not been signed or dated. Medical guidelines insist DNR orders are only issued following discussion with patients or family.

Last night Mrs Ross, of Poynton, Cheshire, said: ' My mother had mild lung cancer and we were assured she would not die in hospital.

'The order lacks every necessary signature, other than that of the issuing doctor, and there is no reference to it in my mother's medical notes.

'When we asked if resuscitation had been attempted the hospital said it had not.'

Her sister Alyson, who runs a gift shop in Poynton, said: 'She went in a feisty, confident lady but became frightened and vulnerable. It is a horror story.'

Mrs Jarvis was admitted to Macclesfield Hospital in 2006 with early onset lung cancer. But her family were unhappy with the care she received in her final days, accusing staff of having a poor attitude and the hospital of being unhygienic.
She was left in dirty clothes, in dirty sheets, and when relatives arrived after she died they found her body 'hanging out' of the bed, they said.

Her family also complained they were not told Mrs Jarvis, who was an active member of the Women's Institute in Poynton, was suffering from E.coli and the superbug Clostridium difficile when she died. They claim they only found out when the infections were listed, alongside the lung cancer, on her death certificate.

Mrs Jarvis's husband, John, 82, a retired scrap metal dealer, was so angry he lodged an official complaint against the NHS trust and was in the process of suing it when he died last year.

His daughters continued the fight and when they requested a copy of their mother's hospital file they discovered the DNR form.

East Cheshire Hospitals NHS Trust said it was unable to comment on the case because of the investigation.

But a spokesman added: 'We will co-operate fully with the General Medical Council.'

Bosses at the hospital have previously apologised to Mrs Jarvis's family for the 'unacceptable level of service' they provided.
Mrs Ross said: 'The care my mother received was disgusting – my Brownie pack could have done better.'

L.Hull@DailyMail.co.uk

http://www.alertuk.org/node/145

http://www.alertuk.org/?q=taxonomy/term/4

http://circ.ahajournals.org/cgi/content/full/115/11/1334
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) FRI.18.APR.2008 @ 19:06hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 20 April 2008

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Posted by Nicholas Dynes Gracey on 19 April 2008
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Temperature Control changes Metabolism changes diabetes ...HOW ?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/gracey-hypothesis-for-cause-and-cure-of.html

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"The Gracey HYPO=thesis" for the CAUSE and CURE of diabetes...

Diabetes is caused by eating too OFTEN which reduces brain/nerve insulin production, reduces liver 'digestion efficiency' and reduces 'glucose insulin resistance' [GIR] ... increasing glucose entry into [and storage in] any 'peripheral tissues' [having insulin receptors] such as liver, fat & muscle cells. Relative-HYPOglycemia is caused by eating too OFTEN especially meals relatively high in carbohydrates. When AnyOne eats, especially carbohydrates/glucose, the blood-stream is usually flooded with glucose. The pancreas releases insulin in response to increasing concentrations of glucose. Insulin increases the efficiency of glucose entry into [and storage in] 'peripheral tissues' such as liver, fat & muscle cells. As a result, blood glucose concentration drops, sometimes resulting in relative-HYPOglycemia. Relative-HYPOglycemia results from brain & nerve cells being deprived of the glucose that has been 'drained' out of the blood-stream by the insulin. The body compensates, by becoming 'glucose insulin resistant', thereby resisting glucose entry into any peripheral tissues having insulin receptors. Now there is a higher glucose concentration remaining in the blood-stream to help better supply the glucose-fuel needs of the brain & nerves. That process is called 'compensatory-HYPERglycemia'. Now whenever AnyOne [who's body is trying to prevent relative-HYPOglycemia] eats EG 'excess glucose' ... their blood glucose concentration rises temporarily, to an above-the-national-average concentration [transient supernormal glycemia aka TSG] in order to help prevent relative-HYPOglycemia [EG type 0, type1, type 2 & type 4 diabetes]. Eating less OFTEN increases glucose insulin resistance and increases 'localized' brain/nerve insulin production [all for 'fine-tuning' of brain/nerve glucose metabolism]. Therefore the CURE for diabetes is to eat less OFTEN so that there are fewer rapid-reductions in brain/nerve glucose concentration and therefore fewer episodes of relative-HYPOglycemia. When EG a Child is growing ... above-the-national-average concentrations of growth hormone are sometimes produced which cause relative-HYPOglycemia. When such a Child eats too OFTEN the pancreatic beta-cells become 'inflamed' in order to help reduce insulin production and increase 'compensatory-HYPERglycemia' [EG type 1a diabetes] ... all in order to help protect the brain/nerves from potential SEVERE acute relative-HYPOglycemia। When an aging Adult eats too OFTEN too often IE too OFTEN for too-LONG-a-time ... the brain/nerve cells become chronically 'starved & inflamed' from lack of 'localized' brain/nerve insulin production, and increase 'compensatory loss-of-appetite' / 'loss-of-memory-to-eat' / 'eating less OFTEN' [EG type 3a diabetes], to help protect the brain from potential SEVERE chronic relative-HYPOglycemia [by increasing 'localized' brain/nerve insulin production]. Eating also causes inflammation [due to various food intolerances associated with an inefficient liver function]. Diabetes is a protective cycle that can be controlled and/or CURED, as required, by intermittent-fasting [which also increases liver 'digestion efficiency'] and intermittent-eating of minimally allergenic foods.


How reasonable is this "Gracey HYPO-thesis"?
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SAT.19.APR.2008 @ 11:14hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 20 April 2008

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Natural Normal Glucose is Relative To Need for Transient Supernormal Glycemia ...HOW ?
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www.NicholasDynesGracey.blogspot.cOM/2008/04/normal-glucose-is-relative-to-need-how.html

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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) SUN.20.APR.2008 @ 23:42hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
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Posted by Nicholas Dynes Gracey on 21 April 2008

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Diabetes results in healthy pregnancy ...HOW ?
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Brain insulin: regulation, mechanisms of action and functions.

Gerozissis K.

Chercheur INSERM, UMR 7059 CNRS, Paris Cedex, France. Gerozissis@yahoo.co.uk

1. While many questions remained unanswered, it is now well documented that, contrary to earlier views, insulin is an important neuromodulator, contributing to neurobiological processes, in particular energy homeostasis and cognition. A specific role on cognitive functions related to feeding is proposed, and it is suggested that brain insulin from different sources might be involved in the above vital functions in health and disease. 2. A molecule identical to pancreatic insulin, and specific insulin receptors, are found widely distributed in the central nervous system networks related to feeding, reproduction, or cognition. 3. The actions of insulin in the central nervous system may be under both multilevel and multifactorial controls. The amount of blood insulin reaching the brain, brain insulin stores and secretion, potential local biosynthesis and degradation of the peptide, and insulin receptors and signal transduction can be affected by metabolic factors induced by nutrients, hormones, neurotransmitter, and regulatory peptides, peripherally or in the central nervous system. 4. Glucose and serotonin regulate insulin directly in the hypothalamus and may be of importance for its biological effects. Central mechanisms regulating glucose-induced insulin secretion show some analogy with the mechanisms operating in the pancreas. 5. A cross-talk between insulin and leptin receptors has been observed in the brain, and a regulation of central insulin actions, potentially via serotonin modulation, by leptin, galanin, melancortins, and neuropeptide Y (NPY) is suggested. 6. A more complete knowledge of the biological role of insulin in brain function and dysfunction, and of the regulatory mechanisms involved in these processes, constitutes a real advancement in the understanding of the pathophysiology of metabolic and mental diseases and could lead to important medical benefits.

http://www.ncbi.nlm.nih.gov/pubmed/12701881
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…Warm thanks & Adrenalin Love :)
Nick Gracey, BSc(Hons) Medical Biochemistry, Birmingham University, UK, WATerian (C) MON.21.APR.2008 @ 23:01hrs c/o www.Love-Diabetes.cOM & www.HYPO-thesis.cOM
AdrenaLINE... www.1MealPerDay.cOM ... "LOVEingly-I-Fast-Every-23hrs-45mins-Or-More"
.

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Someone please explain this, how and why does gastric bypass surgery "CURE" diabetes.....its time for straight answers.

Posted by Anonymous on 24 March 2009

Is there anything that can be done with sealed vials of insulin, after the doctor has switched the patient onto some other form of insulin?

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