Metformin Add-on Drops Fasting Glucose Levels by 12 Points in Phase 2 Trial

Patients taking CRx-401 saw their fasting plasma glucose drop by 12 mg/dl after 90 days.

Jun 3, 2009

CRx-401, an insulin sensitizer intended to assist metformin in type 2 diabetes therapy, has successfully completed a Phase 2 clinical trial in which patients taking it saw their fasting plasma glucose drop by 12 mg/dl after 90 days.

Manufactured by Massachusetts-based CombinatoRx Inc., CRx-401 is a combination of bezafibrate and diflunisal that acts to control glucose, lipids, and inflammation. Bezafibrate is an anti-cholesterol agent, while diflunisal is an analgesic salicylate derivative related to aspirin.

The study was intended to prove that bezafibrate in combination with diflunisal is more effective than bezafibrate alone in reducing fasting blood glucose levels. It tracked 120 metformin-taking type 2 patients whose disease was poorly controlled by that drug alone. (Patients who were taking statins and low-dose aspirin before the study remained on them throughout.)

While all patients continued with their metformin therapy, half received daily doses of CRx-401, in a combination of 400 mg of sustained release bezafibrate and 250 mg of diflunisal. The other half received 400 mg of sustained release bezafibrate and a placebo.

Researchers were looking for positive effects on fasting glucose, A1c's, cholesterol, triglycerides, and insulin resistance.

CombinatoRx president and CEO Alexis Borisy said that the results of the Phase 2 study have encouraged his company to continue testing and evaluating CRx-401 as an eventually marketable diabetes therapy.

Click Here To View Or Post Comments

Categories: A1c Test, Blood Glucose, Diabetes, Diabetes, Insulin, Medications, Medications Research, Metformin, Type 2 Issues


Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Latest
Popular
Top Rated
Print | Email | Share | Comments (1)

You May Also Be Interested In...


Comments

Posted by Anonymous on 8 June 2009

No more lipitor? I could trade one brand name medication for another, but because of the donut hole would not be able to add another brand name med to my overly large stable of medications. Interesting article. Thanks. Helen


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.