Dude! Marijuana Could Be the Basis for a Type 2 Drug

Scientists are researching cannabinoids—chemical compounds derived from marijuana—in the treatment of type 2 diabetes.

Jul 5, 2009

UK-based GW Pharmaceuticals has entered into a strategic alliance with Professor Mike Cawthorne and the Clore Laboratory, University of Buckingham, to research the use of cannabinoids-chemical compounds derived from marijuana-in the treatment of type 2 diabetes.

Cawthorne has a global reputation for his research into treatments for type 2 and obesity. As Group Director for diabetes and obesity research at SmithKline Beecham, he led the research team that developed the drug Avandia (rosiglitazone), a commercially successful insulin sensitizer.

GW's research on the use of cannabinoids in the treatment of type 2 has shown beneficial effects on levels of plasma insulin and on leptin and adiponectin, hormones that factor heavily in both the onset and the treatment of the disease. The research has also shown a reduction in overall levels of cholesterol, while increasing levels of "good" HDL cholesterol.

As a result, the company has developed two cannabinoid-based drugs that have passed through Phase 1 clinical trials: delta-9-tetrahydrocannabivarin (THCV) and cannabidiol (CBD). GW reports that CBD has demonstrated potential beneficial effects on non-fatty liver disease and hypercholesterolemia, the condition in which there is an abnormal amount of cholesterol in cells and blood plasma-often a precursor to artherosclerosis.

THCV's effects so far have included raising energy expenditure, a key element in blood glucose control. GW will combine both drugs in a Phase IIa trial of their effects in the treatment of fatty liver and dyslipidemia (disruption of lipid levels in the blood) in type 2 patients.

GW says the objectives of its alliance with Cawthorne include:

  • Providing GW with a dedicated facility for undertaking pre-clinical pharmacologic studies of cannabinoids in the area of metabolic disease
  • Providing GW with exclusive access to plant-based therapies under evaluation at the Clore Laboratory
  • Supporting the pharmaceutical development of new GW cannabinoid medicines to address defined aspects of metabolic syndrome
  • Getting expert advice from Cawthorne in the metabolic disease area
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Categories: Blood Glucose, Complementary Therapies, Diabetes, Diabetes, Insulin, Research, Type 2 Issues


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Comments

Posted by Anonymous on 16 July 2009

It's a toch subject one that the medical community is now starting to embrace. Medicinal Marajuana in this for as well in many other forms have healing properties with out the side effects. god bless their work.
Find a cure

Posted by Anonymous on 14 November 2009

I suffer from Type 2 Diabetes and the resulting severe nerve damage in my feet. I now read that cannabis is being shown to provide some relief from fibromyalgia in some patients...could there be pain relief from neuropathy in addition? Taking gabapentin 500mg and 2 tramadol 50mg now and it doesn't work but maybe 1/2 the time to get relief. Amazing that an anti seizure med like gabapentin or an anti depressant is prescribed as there is nothing else. Some days I can not walk without severe pain. Damn somebody do something as many of us are really truly hurting here

Posted by Newsome on 20 January 2010

If you have a medical need for marijuana use then why limit it? You have tobacco, liquor, Oxycodone, and much more harful stuff already on the RX Shelves, Why are the poloticians not listening to the doctors? What supports your arguements other than what you have been negitively looking for. I am sure if we dug deep enough into why we should not reelect you then we would find plenty, my point is, if it does the job, and it is a lesser evil then why would Washington DC make it happen for them? Do you think you have ever won an election because you were a chosen lesser evil, I promise no candidate has a 100% approval rate, and it is the older society that is pushing for ignorance when they are supposed to be smarter.. I am a business owner and diabetic, I am not depressed and NEVER smoke around children or family. I am clean cut non hippy stereo type and can pass a drug test right now. But when I have smoked marijuana and I have for many years ( I am in my mid 30’s) and never had a heart attack and never had anytype of negative reaction. Matter of fact ( PROVEN PERSONAL FACT) I am diabetic, it lowers my blood sugars from 250 to les than 100 in 3 hours, I only smoke at night and I have actually been ordered off all diabetic meds, and origionally I was insulin dependant, so what say you about that? Harmful I think NOT!

Ignorance is harmful, even if you personally do not agree to this I know for a fact all diabetics will gain from its use, people just hate what it represents, I agree that alot of people that use it for no medical resoning could increase their exposures to certain ailements but as a medically prescribed drug you should weight the benefiets again.

Marijuana should always be controlled just as alcohol and cigarettes, decriminalzing it would only free up the govt to pursue harsher crimes like Murderes, and Rapists, and Thieves, and CRAK HEADS (meth addicts) they really have not put much thought into leaglization of marijuana in GA, just as it ok to go to a bar on sunday and drink but you cant buy liquor and take it home.. any other day of the week you can buy liquor but sunday, so why is that? DUI ’s are rampant on sundays, ask any local enforcement officer, that $$ day for them, so we are encouraging DUI’s on sunday by not allowing purchase of liquor or beer.

Marijuana is by far the very least of our worries as far as drugs go, it has less of a side effect than a hangover, you are more likely to be drunk and try new things as far as gateway things than marijuana. You have the technology to find out if soone is DUI mor marijuana and alcohol so prosicute it the same way. Do not deny people the treatments they need if they could eliminate the symptoms of diabetes or migrains, or several other case studies. Several poloticians use it, have been found using it, and hav openly admitted to using it, so why the big frown upon its use? Simply put whats wrong with being happy? Society has an opportunity to allow it to be controlled and tax it. I am sure everyone knows somone who smokes and hides it cause of the laws, so why do we not as a people give the govt somthing better to waste our tax dollars on? We could help clear the national debt just with this alone, there are so many reasons why people should look into this again and allow its law makers to pass a law that allows it. Common sence tells you there as many if not more than half that smoke. The law will not stop the determined, so why should it be prosecuted? I mean for real people what you know about it is it illegal and thats about it, when they passed the law to criminalize it they did not have any research in the fields of medicinal use and if they did they sure did not have the technology to back up their arguements. We now do and I think its about time to reopen our minds to the idea that we could have been wrong in making it illegal.

FYI Washington DC and 15 other states and our president have all declared it good for medicine, so why can’t Georgia?

Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, Wyoming


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