Survey Says Most Endocrinologists and Physicians See a Need for More Byetta and Januvia-Type Drugs

Jul 25, 2009

High percentages of endocrinologists, primary care physicians, and managed care organizations surveyed by a research firm say they would like to see additional GLP-1 analogues like Amylin/Eli Lilly's Byetta® and DPP-IV inhibitors like Merck's Januvia® available to treat type 2 diabetes.

The survey, "A Clinician and Payer Perspective on Changing Dynamics in the Diabetes Market: Is There Room for New GLP-1 Analogues or DPP-IV Inhibitors?," published by Waltham, Mass.-based Decision Resources, queried 77 primary care physicians, 72 endocrinologists, and 20 pharmacy directors of managed care organizations:

Regarding new GLP-1 analogues, 89 percent of the endocrinologists, 77 percent of the primary care physicians, and 75 percent of MCO pharmacy directors said they would like to have additional therapies available in that category.

Regarding DPP-IV therapies, 71 percent of the endocrinologists, 74 percent of the primary care physicians, and 70 percent of MCO pharmacy directors said they would like to see additional therapies offered in that category.

In explaining their answers, survey respondents indicated their concerns with Byetta and Januvia. They cited the need for frequent injections with Byetta (twice daily*) and its record of causing severe nausea in some patients. With Januvia, their concerns were with the drug's inability to lower glucose levels as well as the conventional diabetes drug metformin, and questions about its long-term safety.

The criteria respondents cited for adding new GLP-1 therapies included a less frequent need for injections and a lessening of nausea-producing effects. With DPP-IV therapies, they said that an increased ability to lower BG levels would favorably influence their decision to stock or prescribe new drugs in that category.

* A long-range version of Byetta, injected once weekly, is now under review by the FDA. The French pharmaceutical company Sanofi-aventis is currently conducting trials on its own version of exenatide, the generic form of Byetta.

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Categories: Byetta, Complications & Care, Diabetes, Diabetes, Endocrinology, Health Care, Professional Issues, Type 2 Issues

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Posted by thomasgoffe on 25 July 2009

That was a pretty small sample for such a far reaching issue.

Posted by Anonymous on 26 July 2009

Use of Byetta for 3 weeks put me in the hospital for 5 days and weeks at home afterwards. Severe nausea, weakness, and dizziness still persist after 2 months.

Posted by teenymite on 27 July 2009

These products would be helpful if a person could actually afford them!

Posted by Anonymous on 27 July 2009

I'm not trying to sound callous, but aren't MOST (definitely not all) Type-2 diabetics able to reverse their diabetes with proper exercise and nutrition? Why spend $$ on that type of research when the poor people with Type 1 diabetes are the ones who so desperately need a cure?

Posted by Anonymous on 13 August 2009

Posted by Anonymous on 27 July 2009
I'm not trying to sound callous, but aren't MOST (definitely not all) Type-2 diabetics able to reverse their diabetes with proper exercise and nutrition? Why spend $$ on that type of research when the poor people with Type 1 diabetes are the ones who so desperately need a cure?

While I agree with your resoning it's not possible for all type II's to kick diabeties with diet and exercise. If that were the case I would not have it!! With that said i take byetta, it makes me sick sometimes but most of the time it does not. It keeps me under control with A1C's in the low 6's. Yes it's expensive but I have also cut out junk foods that I don't need to help cover some of the cost. Doing this pays for about 1/3 of my drug.

Posted by Anonymous on 12 December 2009

It doesn't sound callous just ignorant. Not ALL people with Type r diabetes are insulin resistant. Some people are similar to type 1's in that their pancreas doesn't work right anymore. No longer makes enough insulin. Not all Type 2's are only insulin resistant. So for some of us there is not enough diet or exercise to make up for that deficiency. Even if it were possible to NEVER eat ANY carbs. Which would be very difficult and not very practical unless you don't ever eat anywhere and only cook for yourself 24/7, 365. Have you ever though about how many places you go, business meeting, events where they serve food and it is sandwiches, cheese, crackers & fruit. Okay for most people but not good choices for people with diabetes. And for some people with Type 2 there are not enough hours in the day to exercise in order to lower out blood sugar enough to not have to take any meds. I cycle and I ride 3 days a week for a couple of hours but I also have to work so exercise has to fit into the day along with many other things in life. If I could ride for 4 or 5 hours every day & never eat any carbs could I get of my meds? I don't know and I am not sure I am wiliing to quit my job to find out. Yes, But it does help, it helps A LOT! But it is not the be all, end all solution. Yes, diet exercise are IMMENSELY important tools in keeping type 2 diabetes under control but will not make it "go away". Some people just need meds. And as far as there being more options for these type of drugs... I am ALL for that. More choices, a variety of products on the market I think would help to drive down prices, competition is a good thing but mostly because everyone doesn't respond to the same drug so more options might help more people. Hope this helps more people understand! A lot of people that have diabetes when they are older fall victim to Type 2 and may "bring it on themselves" by eating junk food, sweets, being overweight & out of shape (with the immense rise in the number of people with Type 2 along with the increase in overweight people as we eat more fast food & become more sedentary I think there can't help but be a connection there. I won't argue that) but I also think there are some other connections too. Heredity? I am the only person in my family that is not overweight or obese. I am also the only person in my family with diabetes. I am also adopted. I don't know my family history but, I can't help but wonder is there any in my biological family that has Type 2. Did their pancreas give out too, hhhmmmm. I wonder.....

Oh, and I take Januvia and I haven't had any negative side effects. It is expensive and I didn't eat junk food anyway so no real way to cut back there I just suck it up and pay it because it works and the outcome from not keeping by blood sugar under control would be even more expensive in the long run! And I feel better and am a healthier person : )

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