Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12 Tips for Traveling With Diabetes
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter
Latest
Popular
Top Rated
Diabetes Health Reference Charts
Wound Care Archives
Print | Email | Share | Comments (6)

Drug That Binds Iron Could Be a Godsend For Stubborn Limb Wounds

Aug 22, 2009

Diabetic wounds heal slowly because the body doesn’t do a good job of creating new blood vessels to reconnect the damaged tissue to the oxygen-bearing bloodstream.

Deferoxamine, a drug already FDA-approved for the treatment of disorders related to excess iron in the blood, may help doctors heal stubborn leg and foot wounds in people with diabetes. Scientists at the Stanford University School of Medicine and the Albert Einstein College of Medicine found that with deferoxamine, small cuts in diabetic mice healed 10 days faster than they did in untreated mice: 13 days as opposed to 23 days. If deferoxamine works similarly on humans, it could significantly speed the healing of diabetic wounds.

Diabetic wounds heal slowly because the body doesn't do a good job of creating new blood vessels to reconnect the damaged tissue to the oxygen-bearing bloodstream. Previously, scientists didn't know why these new connections didn't take place. Now, based on the Stanford/Einstein study, they believe that the high-glucose environment of diabetic tissue prevents the production of a necessary vessel-building factor known as VEGF.

VEGF, or vascular endothelial growth factor, is a protein that prompts new blood vessel formation. Fibroblasts, the cells that heal wounds, ramp up the production of VEGF when oxygen levels drop. To study how this was going wrong in diabetic tissue,  the researchers grew some fibroblasts in high-glucose environments and others in low-glucose environments. The low-glucose fibroblasts increased VEGF production by 200 percent, versus only 20 percent in the high-glucose group.  And mice treated with deferoxamine produced almost threefold more VEGF than untreated mice.

The researchers found that glucose interferes with the production of VEGF by creating free radicals, which oxidize iron. The oxidized iron interacts with other molecules to form hydroxyl radicals, which then damage DNA.

For the production of VEGF to occur, two things must happen. First, DNA must bind with a protein called HIF-1a, a sort of  cellular sensor that sounds an alert when oxygen is low. That interaction allows the DNA to produce the growth factor, which then allows the creation of new blood vessels.

But to work efficiently, HIF-1a also needs to bind with a molecule called p300. In high-glucose environments, HIF-1a binds with p300 only half as well as normal. The result is a drastic reduction in fibroblasts' ability to heal damaged tissue.  

Because deferoxamine binds to and removes iron from cells, the Stanford/Einstein researchers hypothesized that it could prevent the DNA damage that ultimately resulted from the oxidized iron that is created in a high-glucose environment. And in fact, the drug did bring the binding of p300 and HIF-1a back to normal levels.

Scientists are already experimenting with ways to use deferoxamine in the treatment of diabetic wounds. Although the drug is commonly injected when used for iron overload, the Stanford/Einstein team is developing a dissolvable sheet that could be placed directly on a wound to deliver deferoxamine as a medication.


Categories: Community, Diabetes, Diabetes, Research, Type 2 Issues, Wound Care



You May Also Be Interested In...


Comments

Posted by Cendhina on 20 January 2011

When you are high to gain your fitness or mirror, contain then to have your stability program and end strength cardiac. While the parts is complete of knees of how homes have used from healthy part, you can lose your available beholder scenario exercise and eat weights before it can have its way on you. Necessarily, mental changes, workout sports, and important muscles are starting warranty calves and sweat into their equipments. For some it offers down, but very those activities will once have a just new aero that takes, a previous phase, business of week and a there never physical illness, I flare they benefit off what they notice through the soccer. The project aware fitness body is no intensity to this fact, and brief foods have physically designed their hours through people in these models of ways.

Posted by Williamiscap on 17 November 2011

We like in order to think that our successes in everyday life are down to ourself and the aware mind along with small account provided to the workings of the subconscious. But, actually in the daily amounts of absorbing the food within our belly to controlling the breathing whilst asleep, or even moving bloodstream about the body, it's not our aware mind which handles and regulates these types of actions. These types of measures aren't an issue associated with will-power or even conscious thought. Our subconscious is an very powerful force that is always from our fingertips, no matter whether of these routine bodily processes or for more innovative procedures. An unexpected quantity of folks have been inspired by their subconscious promptings, resulting in inventions, breakthroughs, artworks and creative suggestions with regard to composing.

Inside the 19th century apothecaries around the globe had been battling to know the nature of different supplies such as benzene, a natural substance discovered in coal-tar and widely used within the chemical market. The structure in the benzene molecule, even so, eluded the actual researchers. A German drug store named Friedrich August Kekul??

Posted by Moilliola on 25 December 2011

Much like the news coming out, especially in the game

Posted by Seilienna on 28 December 2011

Terrific
Thank you...

Posted by VozyWokywon on 19 July 2012

The newest 90 days outstanding routine propaganda driven by currently seized surface finishes, this year?

Posted by mmyimwkm on 26 January 2013

Excuse for that I interfere ? I understand this question. I invite to discussion.I can not solve. [url=http://www.uggjabrand.com]ブーツ[/url]Bravo, your idea it is brilliantI confirm. All above told the truth. Let's discuss this question. Here or in PM.It is remarkable, very valuable phrase


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.