Gut Hormone That Controls Glucose Production Could Become Diabetes Therapy

Scientists found that CCK and its variants work independently of the levels of insulin in the bloodstream. But interestingly, only a few days of high fat intake create a resistance to CCK that is similar to insulin resistance.

Aug 27, 2009

Canadian scientists have reported that a hormone found in the gut has the power to lower glucose production by signaling the brain and liver to do so. When the researchers activated its receptors in lab rats, they found that the hormone, called cholecystokinin (CCK) peptide, rapidly lowered the animals' blood glucose levels.

However, they also found a drawback: CCK's power is blunted when there are high levels of fat in the bloodstream. In rodents that were fed a high-fat diet for three days, the hormone failed to have any effect on glucose levels.

CCK lowers glucose production by binding the receptors of nerves in the small intestine and making them send a signal to the brain to stop production. The brain, in turn, sends the command to the liver.

The scientists found that CCK and its variants work independently of the levels of insulin in the bloodstream. But the fly in the ointment is the introduction of fat into the diet. Only a few days of high fat intake create a resistance to CCK that is similar to insulin resistance.

If the researchers can duplicate CCK's effects in humans, the next goal will be to find a way to get the hormone to work despite high bloodstream fat levels. If so, it could become the basis of a more benign therapy that works by lowering glucose production, but not by addressing the liver directly.

The Canadians published their findings in the August 2009 issue of Cell Metabolism in an article called,  "Intestinal Cholecystokinin Controls Glucose Production Through a Neuronal Network."

Click Here To View Or Post Comments

Categories: Blood Glucose, Blood Sugar, Community, Diabetes, Diabetes, Health, Health Care, Insulin, Pre-Diabetes, Research

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...

Username: Password:
©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.