Metabolic Syndrome in Early Pregnancy Increases the Risk of Preterm Birth

This press release is an announcement submitted by AADE, and was not written by Diabetes Health.

The risk for preterm birth was nearly tripled in women with metabolic syndrome early in pregnancy.

Oct 16, 2009

NEW YORK (Reuters Health) Oct 13 - Women with metabolic syndrome in early pregnancy have a higher risk for preterm birth, according to study findings reported in the October 1st issue of the American Journal of Epidemiology.

Dr. Leda Chatzi, of the University of Crete, Greece, and colleagues base this conclusion on their study of 625 women who were members of Crete's mother-child "Rhea" cohort, on whom data was gathered from 2007 to 2009.

The authors defined "metabolic syndrome in early pregnancy" as the presence of three or more or the following at or before 15 weeks' gestation: pre-pregnancy BMI >30 kg/m2, triglyceride level of 150 mg/dL or more, HDL cholesterol <50 mg/dL, fasting glucose of 100 mg/dL or more, and blood pressure of 130 mmHg or more systolic and 85 mmHg or more diastolic.

The prevalence of the metabolic syndrome in early pregnancy was 3.5%, the researchers report. The risk for preterm birth was nearly tripled in women with metabolic syndrome early in pregnancy (relative risk = 2.93). The highest risk was observed for medically indicated preterm births (RR = 5.13).

Among the components of metabolic syndrome, hypertension was the most significant risk factor (RR = 3.92).

Each elevation of 10 mm Hg in diastolic blood pressure increased the relative risk for preterm birth by 29% and the risk of medically indicated preterm delivery by 67%.

Furthermore, an elevation of 40 mg/dL in total cholesterol increased the relative risk for all preterm births by 24%. For medically indicated preterm births, the relative risk was increased by 52%. Each per unit increase in the LDL/HDL cholesterol ratio increased the relative risk for preterm birth by 19%.

Fetal weight growth restriction was associated with elevated levels of insulin in early pregnancy (RR = 1.14) and elevated levels of diastolic blood pressure (RR = 1.27).

"The complex underlying processes that explain these findings require additional study," Dr. Chatzi and colleagues said. "Further follow-up of this cohort will allow (us to determine) if metabolic syndrome in early pregnancy has, in addition, an effect on cardiovascular risk in childhood and also long-term maternal health risks."

Am J Epidemiol 2009;170:829-836.

* * *


Click Here To View Or Post Comments

Categories: Insulin, Pre-Diabetes, Pregnancy, Research

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...

Username: Password:
©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.