Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12 Tips for Traveling With Diabetes
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter
Latest
Popular
Top Rated
Beta Cells Archives
Print | Email | Share | Comments (0)

Malfunctioning Pancreatic


Jun 29, 2010

Insulin-producing beta cells in the pancreas have their own biological clock that controls the production of insulin over a 24-hour period.

A malfunction in the pancreas's "circadian clock*," the built-in timer found in all living things that regulates major biological processes, may be one of the reasons that people develop diabetes.

Scientists at Northwestern University near Chicago have found that the insulin-producing beta cells in the pancreas have their own biological clock that controls the production of insulin over a 24-hour period. If that clock is tampered with, beta cells lose their ability to produce insulin-a lack that is a known precursor to diabetes.

The researchers experimented on mice by inhibiting genes in their pancreases that they had determined control the organs' circadian clocks. Once they did so, the animals began losing the ability to produce insulin, became glucose-intolerant, and developed full-blown diabetes.  

Before blocking the genes, the scientists used bioluminescent imaging to show that the pancreas has an autonomous circadian clock. When the islet cells produced insulin, they stimulated a bioluminescent substance and gave off light. Because insulin production came at regular 24-hour intervals, this was proof of an internal timing mechanism.

While establishing that there is a circadian clock in the pancreas (along with tissue in other parts of the body, such as the liver, lungs, heart, and skeletal muscles), the Northwestern researchers could not say what causes it to fail or malfunction.

One next step may be to seek ways to manipulate the clock, perhaps genetically, to operate normally. That could become the basis for a therapy that attempts to restore beta cell functioning.

*Circadian is based on the Latin words circa-"about" and diem-"day" to denote a 24-hour biological rhythm.

* * *

Source:

Circadian clock in pancreas linked to diabetes

http://timesofindia.indiatimes.com/Life/Health-Fitness/Health/Circadian-clock-in-pancreas-linked-to-diabetes-/articleshow/6067332.cms


Categories: Beta Cells, Diabetes, Diabetes, Health Research, Insulin, Research, Type 2 Issues



You May Also Be Interested In...


Comments


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.