Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12 Tips for Traveling With Diabetes
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter
Latest
Popular
Top Rated
Research Archives
Print | Email | Share | Comments (0)

Stem Cell Study Focuses on Reducing Amputations


Mar 27, 2011

Researchers at the University of California at Davis have begun a study to see if patients' own adult stem cells can be used to increase lower leg blood circulation and possibly prevent amputation  due to arterial disease or diabetes.

About 85,000 leg amputations occur each year in the United States as a result of arterial disease. The condition that causes arterial disease, atherosclerosis, occurs when a build-up of fat, plaque, and calcium hardens arterial walls and greatly reduces blood flow to the legs and feet.

Common therapies include forcing arteries open with balloons, reinforcing them with stents, or bypassing them with grafts. But those approaches don't always work, opening patients to the possibility of amputation as a final therapy.

If a way could be found to use patients' own stem cells-which would not cause an autoimmune reaction-to form new blood vessels, it would be possible to bypass damaged vessels and reinvigorate blood flow to the lower extremities.

The UC Davis study will perform a surgical procedure that extracts bone marrow from a patient's pelvis, then spins it in a centrifuge to separate out cell material that includes endothelial progenitor cells-the stem cells that form a person's blood vessels in the womb. The cells will then be injected at various points along a damaged leg that is at risk for amputation.

The hope is that the procedure will result in new, healthy blood vessels. Study subjects will return to UC Davis five times in the year after they undergo the procedure.

The trial sponsor is Biomet Biologics of Warsaw, Indiana, which manufactures the specialized equipment, called MarrowStimTM, that the study will use to extract blood cells from bone marrow, as well as the centrifuge that separates and concentrates the cellular material.


Categories: Amputations & Amputee, Diabetes, Diabetes, Health Care, Health Research, Research



You May Also Be Interested In...


Comments


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.