Researcher Looks Into Protein That May Prevent Type 2 in Obese People

Protein That May Prevent Obese People From Developing Type 2 Diabetes

| Apr 22, 2011

The National Institutes of Health has awarded a $1.15 million grant to a researcher at Eastern Virginia Medical School to investigate a protein that may prevent obese people from developing type 2 diabetes.

The researcher, Yumi Imai, MD, will focus on a regulatory protein called adipose differentiation-related protein. ADFP facilitates efficient use of lipids, fatty molecules that the body uses to store energy.

Fat contains high levels of lipids. In obese people, those lipids eventually move into the bloodstream, where they can cause organ and muscle inflammation. In the islet cells that produce insulin, inflammation can eventually damage production and lessen the hormone's effectiveness, often leading to type 2.

Dr. Imai theorizes that ADFP functions as a kind of flow control, leading lipids through islet cells so that the cells can absorb energy from them, but preventing the volume of lipids from overwhelming the cells and damaging them. She thinks that obese people may have too little ADFP.

However, some obese people do not develop type 2 despite having all of the preconditions for it. In those cases, Dr. Imai will look to see if they have naturally high levels of ADFP.

If ADFP functions the way Dr. Imai suspects, confirmation could open the door for a new type 2 therapy that can control lipid damage to insulin-producing cells. She and her team at EVMS's Strelitz Diabetes Center will use mice and tissue cultures, in conjunction with a high-fat diet, to see how different levels of ADFP affect the development of type 2.


Click Here To View Or Post Comments

Categories: Diabetes, Diabetes, Health Care, Insulin, National Institutes of Health, NIH, Obese, Obesity, Overweight, Pre-Diabetes, Research, Type 2 Issues

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...

Click Here To View Or Post Comments

Comments 0 comments - Apr 22, 2011

©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.