Home
You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View
See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.
Latest Glyburide Articles
Popular Glyburide Articles
Highly Recommended Glyburide Articles
Email to a Friend
Send a link to this page to your friends and colleagues.
Danish Study Reports Three Diabetes Drugs Best for Lowering Cardiovascular Risk
Cardiovascular Risk
A Danish study of 107,806 adults taking various diabetes medications has found that three drugs are the most effective at lowering the risk of cardiovascular disease and death: metformin, gliclazide (not marketed in the US), and repaglinide (Prandin). Other common diabetes medications, including glimepiride, glibenclamide (glyburide), glipizide, and tolbutamide, were linked to a higher risk of death both from all causes and from heart attack and stroke.
Researchers looked at the patients in the study group who had never had a cardiovascular event (9,607 had experienced a previous heart attack or stroke) to see which drugs might be more closely associated with a higher risk of death from all causes. They found that people taking glimepiride ran a 32 percent higher risk, while those taking glipizide ran a 27 percent higher risk, and those taking glibenclamide ran a 19 percent higher risk. People taking tolbutamide versus metformin ran a 28 percent higher risk of death.
The researchers reported that the risks were even higher for people taking these drugs who had experienced previous cardiovascular events.
Previous research has shown that metformin reduces the risk of major cardiac events and death by about 40 percent compared to placebo. The Danish study showed that the risk profiles posed by gliclazide and repaglinide were about the same as metformin.
The drug classes of the above-named drugs include:
• Glibenclamide/Glyburide: sulfonylurea
• Gliclazide: sulfonylurea
• Glimepiride: sulfonylurea
• Glipizide: sulfonylurea
• Metformin: biguanide
• Replaginide: meglitinide (also "glinides")
• Tolbutamide: sulfonylurea
The researchers cautioned people with diabetes to consult with their doctors if they are concerned about potential dangers from the drugs they're taking. Unilaterally ceasing prescribed medications could be dangerous.
Results of the study were published online in the European Heart Journal.
Categories: , Complications & Care, Diabetes, Diabetes, Glyburide, Heart Disease, Medications Research, Metformin, Prandin, sulfonylurea
You May Also Be Interested In...
-
Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
-
Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
Comments
This is incredibly important information, given the millions worldwide taking these drugs. I'll get a copy of the article and review it at my diabetes blog soon.
-Steve
Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.
When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.
For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.
Don't have your Diabetes Health Username? Register now and add your comments to all our content.
Register...
Register your Diabetes Health Username here.
Have Your Say...