N.J. Hospital Teams With Ricordi to Find Cure for Type 1

Dr. Camillo Ricordi

| May 18, 2011

New Jersey's Hackensack University Medical Center has announced that it will partner with Dr. Camillo Ricordi to test a surgical procedure that could hold the key to a cure for type 1 diabetes.

Ricordi, scientific director of the University of Miami Diabetes Research Institute, has experimented with implanting insulin-producing pancreatic islet cells in the abdomens of monkeys rather than in their livers. The procedure attempts to avoid the problems of auto-immune reactions when donor cells are implanted into type 1 recipients.

In type 1 diabetes, which is considered an auto-immune disease, the body wrongly attacks pancreatic islet cells, which produce insulin, eventually destroying them. Transplantation of donor cells is an established procedure, but the subsequent need for recipients to take drugs to suppress an auto-immune response to the foreign cells is expensive, burdensome, life-long, and often opens the door to other diseases.

Ricordi has had some success with his approach in monkeys, and the partnership with Hackensack University Medical Center will assist him as he moves into experimenting with human test subjects. Ricordi will recruit four subjects, none of whom is responding to current treatments, and begin working with them next year.

Another problem is that the number of transplant donors, which can even include cadavers, is too small to meet the needs of every potential transplant recipient. So the partnership will also look into ways to create a reliable supply of islet cells.

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Categories: Animal Insulin, Artificial Pancreas, Case Studies, Diabetes, Diabetes, Diabetes Cure, Insulin, Insulin Resistance, Islet & Pancreas Transplant, New Cure Research, Type 1 Issues

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Posted by Anonymous on 19 May 2011

Thank God for scientists who are focused on finding a cure for Type 1 diabetes. They inspire me with hope for a better future every day.

Posted by Anonymous on 20 May 2011

OK, so let's say this finally works..
Now what? Where are we, in the USA going to get enough Islet cells to take care of (a) over 2.5 Million T1's and (b) Future ave of how many born every yr?

They're going to need alot of Embryo's and Islet Cells, Right?

You think the religous Right will allow this? Keep some $ handy for a Plane ticket to Either Canada , Europe or South America

Posted by Anonymous on 25 May 2011

I think this is a great idea in trying to avoid the immune response and subsequent need for immunosuppressive drugs, however; I agree with the prior post. What about the shortage of islets? Every single article you read on this topic says the same thing, they don't have any viable way of producing islet cells en mass, that isn't potentially toxic! If this proves to be a more successful treatment in avoiding the immune response, then what?

Posted by Anonymous on 25 May 2011

I guess the procedure will be performed based upon priority "brittle diabetics" get first supply from cadavers, unless your like a Steve Jobs and can game the system.

Posted by Anonymous on 26 May 2011

Don't lose hope. You need to check out all resources - JDRF, ADA, and other institutions that are reporting cutting edge treatments. There are options and ideas on the table to ensure there are enough islets and that are NOT from embryonic cells. The real issue, as in most research, is the FDA and their numerous guidelines and hurdles.

Posted by Anonymous on 30 May 2011

While we still face the hurdle of generating islets, and the stem cell debate hurdles on in this country this is a tremendous first step in solving this part of the problem. Let's cross our fingers and support this step. Then we can tackle the next one. Great work Dr. Ricordi; let's hope these human trials go well!

Posted by Anonymous on 8 January 2012


Posted by Anonymous on 23 January 2012

Keep dreaming. 1/3 of medicine would disappear if they "cured" Diabetes. they'll come up with some way for all the parties at hand to "win win" in the next decade I'd bet. With diabetics requiring a regular infusion of genetically engineered cells, and at a huge cost. Funny, they can make an e-coli bacteria generate insulin by altering its RNA. This costs virtually nothing, but the drug companies charge 100 USD per bottle for the newest fast acting insulins. The bacteria also produce enough insulin to satisfy the world's diabetic needs. Why can't these corporations fix the problem faced by those of us with the disease? Seem ironic? Nobody gives a rat's ass about those with DM. Pharmaceuticals and supply manufacturers enjoy a multi-billion if not trillion dollar cash cow. Think about all the MD's who would be without large volumes of clientel should the 6th leading cause of death in the US just up and go away? Endocrinoligists would basically be without a job, think those with Lupus are going to keep all of them in business? They're not likely to let it happen either. Sorry folks Greed doesn't only win in politics and wallstreet. Do no harm is a bit of an over statement. The cure has been around the corner forever friends; time to wake up and realize the wool will never be given up by the sacrificial lamb. Diabetes is here to stay.

Posted by Anonymous on 25 February 2012

Finally they are working on it

Posted by Anonymous on 29 March 2012

I have been a T1 for 17 years and have heard so many rumors since I was diagnosed in 95 and nothing yet. Everything seems so promising but then its like it all fails...I still will not give up hope on this issue but I really can't see a cure in my life...although I hope im wrong but then again I seriously doubt the FDA will pass anything just for the simple fact that all these companies that produce supplies and insulins will be out the billions of dollars they make on us diabetics buying the products we need and even be out of their jobs so I see big problems with this

Posted by Anonymous on 30 April 2012

I stay strong for my daughter who is 10. she has been T1 for 3 years. I am a father and I wanna cry but I know if I do I may not be able to keep it together. I am mad at god but pray every day for a cure. I blame the infant shots the Dr's say we have to have and the drug companies. GOD I hate you right now. How much more are you going to test me? Did I do something wrong?

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