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Sanofi Says Late-Stage Trial of Type 2 Drug a Success
French drug maker Sanofi-aventis
French drug maker Sanofi-aventis says that results from a Phase III trial of its experimental type 2 diabetes drug lixisenatide show that the drug successfully lowered patients' blood glucose levels and body weight, but did not increase the risk of hypoglycemia.
Lixisenatide is a GLP-1 agonist, one of a family of drugs that work by stimulating the release of insulin when blood sugar levels rise too high.
The Phase III study tracked 361 type 2 patients with A1C levels between 7% and 10% who were not receiving any therapy for blood glucose. The patients were divided into three groups, two that took once-daily doses of the drug at different levels of strength, and a third that received a placebo. The test lasted 12 weeks.
Sanofi says that the two groups taking the experimental drug experienced "significantly reduced" A1C levels-including levels below 7%-and "significantly improved" fasting plasma glucose and two-hour post-meal glucose.
If lixisenatide gains FDA approval to go to market, it will join a field of GLP-1 agonists that includes Amylin and Eli Lilly's Byetta (exenatide) and Novo Nordisk's Victoza (liraglutide). Financial analysts say the drug could carve out a $500 million niche in the U.S. market.
Categories: A1c Test, Blood Glucose, Byetta, Diabetes, Diabetes, Eli Lilly, FDA, Hypoglycemia Unawareness, Novo Nordisk, Type 2 Issues, Victoza
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May 23, 2011
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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