Aussies Take Step Toward Vaccine for Type 1

Australian Researchers Hope Nasal Spray Will Lead to a Vaccine

| Jul 13, 2011

Immunologists at a research institute in Melbourne, Australia, say they have successfully tested a nasal spray that suppresses an immune response in people who are genetically disposed to type 1. The test, performed by scientists at the Royal Melbourne Hospital, is the first time that the spray has been tried on humans.

In type 1 diabetes, an autoimmune disease that has a genetic component, the body begins to develop antibodies that mistakenly attack beta cells. Eventually the antibodies destroy the cells, leaving a person incapable of producing insulin. The spray, which the researchers hope will lead to a vaccine that prevents the onset of type 1, works by blocking the effect of the antibodies that attack the pancreatic beta cells.

The nasal spray, which contains an insulin solution, is being tested on people who have already developed two of the antibodies associated with the onset of type 1. The study participants also have relatives with type 1 and are therefore genetically at greater risk of developing the disease.

The nasal spray is being developed by Australia's Diabetes Vaccine Development Centre, in collaboration with the New York-based Juvenile Diabetes Research Foundation. The researchers stress that any vaccine that results from their tests will be aimed at preventing, not reversing, type 1.


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Categories: Autoimmune Condition, Antibodies, Diabetes, Diabetes, Immune Systems, Insulin, Type 1 Issues

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Posted by Anonymous on 13 July 2011

How many years before you would be able to say it's a true "vaccine"? We have heard this all before and living in the USA the FDA may want to delay it's usage, citing numerous "Safety Concerns" and requesting extra "Documentation".

Posted by Anonymous on 19 July 2011

If we already know that the beta cells in the pancreas can still regenerate, even in long standing Type 1 diabetes, then why wouldn't this be used to reverse Type 1?

Posted by Anonymous on 20 July 2011

The problem we have is there are never any in depth reporting, it's all headlines. I have yet to see just 1 of these "findings" or "breakthroughs" mean anything for the sufferer. It all finds a place in text books/academia but not at the bedside. The ability for beta cell regeneration has long been known and I agree this should have some potential but not if it never makes it to the bedside. That's the problem! It takes too long and the research gets lost or burried until the next "headline" or political agenda.

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