Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12 Tips for Traveling With Diabetes
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter
Latest
Popular
Top Rated
Cardiovascular Disease Archives
Print | Email | Share | Comments (0)

Medtronic’s New CAD Stent Is a Boon for Diabetic Patients


Mar 9, 2012

The Resolute Integrity stent

(Editor's Note: Some information in this article is from a press release issued by Medtronic, Inc.)

Minneapolis-based Medtronic, Inc., has announced FDA approval of its Resolute IntegrityTM Drug-Eluting Stent for the treatment of coronary heart disease. It is the first DES approved in the US for use with diabetic patients who have CAD.

Patients with CAD often undergo a therapy called percutaneous coronary intervention. Also known as angioplasty, PCI involves placing small devices called stents into arteries that have been clogged by plaque. Stents are small tubes that help expand and support an arterial pathway. A drug-eluting stent not only works to keep narrow arterial passages open and reinforced, it is coated with medicine designed to treat arterial damage.

Because people with diabetes run a substantially higher risk of cardiovascular disease than the non-diabetic population, they often require treatment for clogged arteries. But they present certain problems: They tend to have smaller and often tortuous arteries, and longer lesions in them. Doctors using conventional stents with diabetic patients often have been frustrated by a relatively high rate of failure. These have been brought on by the need for repeat procedures, or in some cases, the onset of stent thrombosis, where blood clots form in the stent.

To address the clinical need for a stent that would work well in people with diabetes, Medtronic designed several clinical trials to test the Resolute Integrity DES. A global clinical program, consisting of a large, randomized, controlled trial, and a series of confirmatory single-arm studies, involved nearly 250 sites in 32 countries. In all, the program enrolled more than 5,100 patients who received a Resolute DES; about a third (1,535) of them patients had diabetes, a proportion that mirrors the US patient mix.

The clinical trials found that the new stent performed similarly in both CAD patients with and without diabetes.

The new Medtronic stent is based on use of a proprietary engineering advance called continuous sinusoid technology. CST molds a continuous metal strand into a sinusoidal wave-like the waves on an oscilloscope-and then wraps it in a spiral pattern to produce a device that is comparable to a flexible spring. The polymer-based stent is then infused with drugs. 

Martin B. Leon, M.D., director of the center for interventional vascular therapy at New York-Presbyterian/Columbia University Medical Center, and a principal investigator of the RESOLUTE US clinical study, said "It's exceptionally easy to navigate the stent on the delivery system through the coronary vasculature to the narrowed arterial segment that requires treatment." He said that the device's combination of deliverability, efficacy, and safety, as well as FDA approval for its use in diabetes patients, holds out promise that it will gain rapid acceptance nationwide.  


Categories: Cardiovascular Disease, Coronary Heart Disease, Diabetes, Diabetes, Diabetic Patients, Medtronic



You May Also Be Interested In...


Comments


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.