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Type 1s May Produce Insulin for Decades After Diagnosis
Massachusetts researchers have found that even years after they are diagnosed with type 1 diabetes, some people continue to possess functioning beta cells. This finding departs from the conventional thinking that in type 1 diabetes beat cell activity inevitably ceases--the result of attacks on the cells by the body's immune system.
In their study, researchers at Massachusetts General Hospital in Boston checked blood samples from 182 type 1 patients for C-peptide, an indicator of beta cell insulin production. They found that C-peptides can be present in people who have been diagnosed with type 1 for decades, including 10 percent of patients who have had the disease for more than 30 years.
Additionally, researchers found that the although C-peptide levels declined over the years in type 1s, the decline was gradual, not abrupt. Previous thinking held that as a result of the body's attack on beta cells, insulin production, and therefore C-peptide levels, would fall quickly and dramatically.
The possibility that the pancreas retains some beta cell functioning even years after diagnosis To generate their findings, scientists used an ultrasensitive assay for C-peptide that is 22 times more sensitive than the current assay standard. They think that its use could open the way to treatment at much later stages of type 1 diabetes than has previously been considered.
Source: Diabetes Care
Categories: Assay, Beta Cell Insulin Production, C-peptide, Diabetes, Diabetes, Immune System, Massachusetts General Hospital, Type 1 Diabetes, Type 1 Issues
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Mar 19, 2012
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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