3 Factors Combine to Dramatically Increase Risk of Type 2

3 Factors Combine to Dramatically Increase Risk of Type 2

| Mar 24, 2012

Three risk factors-insulin resistance, fatty liver, and overweight/obesity-that are commonly associated with the onset of type 2 diabetes can each, by itself, substantially increase the risk of developing the disease. But in individuals that have all three factors working in combination, the risk of developing type 2 in a five-year period increases 14-fold.  

Korean researchers, publishing their findings in Diabetes Care, reported that they recruited 12,853 non-diabetic South Koreans in 2003 for the study. Five years later, in 2008, 223 members of the patient study group had developed type 2 diabetes. Among them, the three risk factors had occurred in the following percentages:

  • 26 (12 percent) of the persons who had acquired diabetes had none of the risk factors
  • 37 (17 percent) had one risk factor
  • 56 (25 percent) had two risk factors
  • 104 (47 percent) had all three risk factors

Researchers say their study took into account other factors that could affect the acquisition of type 2, including age, sex, education, smoking, alcohol consumption, exercise habits, and triglyceride levels.

By itself, insulin resistance increases the risk of type 2 by a factor of 3.92, while fatty liver and overweight/obesity each increase the risk by a factor of 2.42. The risk from two factors in combination  depended on the factors: Fatty liver and overweight/obesity together increase the risk of diabetes by a factor of 3.92, while insulin resistance combined with fatty liver produced a risk factor of 6.73.

The Korean researchers noted that fatty liver, though not as significant a factor as insulin resistance, is increasingly being seen as an independent risk factor for diabetes. While calling for more research into the three factors, they suggested that treatments specifically targeted at each factor might be the best approach to treating patients that have two or more of the factors present.

Click Here To View Or Post Comments

Categories: Diabetes, Diabetes, Fatty Liver, Insulin Resistance, Overweight/Obesity, Risk Factors, Type 2 Diabetes, Type 2 Issues

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...

Click Here To View Or Post Comments

Comments 0 comments - Mar 24, 2012

©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.