Scientists May Have Found Key to Neuropathic Pain

| May 26, 2012

A compound found in excessive quantities in the glucose of people with diabetes may hold the key to successful treatment of neuropathic pain, says an international team of researchers.
The compound, methylglyoxal, attacks and modifies a protein, called Nav1.8, in nerve endings.

This damage causes nerves to become much more sensitive to pain and temperature extremes.The result in people with diabetes is neuropathy, nerve damage, and pain, especially in the limbs. An estimated 50 percent of people with diabetes suffer from this demoralizing and debilitating condition.

Researchers, led by the University of Warwick in the UK, think that removing methylglyoxal from diabetic glucose could be one way to counteract the development of neuropathy. They are currently looking into an enzyme called Glo1, which causes methylglyoxal to undergo a chemical change that cancels its ability to attack nerve endings.

Damage from high blood sugar has been a known factor for many years. But pinpointing this one specific effect opens the door for an effective anti-pain therapy.

Click Here To View Or Post Comments

Categories: Anti Pain, Compound, Diabetes, Diabetic, Enzyme, Glo1, Glucose, High Blood Sugar, Limbs, Methylglyoxa, Nav1.8, Nerve Damage, Neuropathy, Pain, Protein, Therapy, University of Warwick


Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • What's on the Horizon with Diabetes Research and Therapy
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Latest
Popular
Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Comments


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.