Home
You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View
See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.
Latest Type 2 Diabetes Articles
Popular Type 2 Diabetes Articles
Highly Recommended Type 2 Diabetes Articles
Email to a Friend
Send a link to this page to your friends and colleagues.
Biological Clock Molecule Could Become New Type 2 Treatment
Biological Clock Molecule Could Become New Type 2 Treatment
UC San Diego scientists have discovered a molecule involved in regulating the biological clock that could open a new path for treating type 2 diabetes. The molecule, dubbed KL001, controls a key protein, cryptochrome, that regulates the biological clock (circadian rhythm) in plants, animals, and humans. In doing so, cryptochrome indirectly affects the liver's production of glucose. KL001 can be manipulated to induce cryptochrome to slow the liver's glucose production, thus creating a possible new therapeutic approach to type 2 diabetes.
The circadian rhythm controls the timing of certain metabolic processes. For example, nightly hormonal signals tell the body to go into a fasting state because it's getting ready to sleep. By day, when people are active and eating, fasting signals are suppressed so that the body will produce more glucose for energy. In the case of people with diabetes, whose glucose levels go too high, the ability to "tell" the liver to ease off glucose production could help them achieve better control.
The path to finding KL001 started two years ago when a research team led by Steve Kay, dean of the Division of Biological Sciences at UC San Diego, discovered a biochemical link between diabetes and the circadian rhythm. The team determined that cryptochrome, already known to regulate the biological clocks of plants and animals, also regulates the liver's glucose production. That insight led to speculation about ways that cryptochrome could be controlled and the eventual discovery of the KL001 molecule.
Source: UC San Diego press release.
Categories: Diabetes, Diabetes Health, Diabetic, Glucose, Research, Type 2 Diabetes
You May Also Be Interested In...
-
Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
-
Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
Comments
Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.
When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.
For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.
Don't have your Diabetes Health Username? Register now and add your comments to all our content.
Register...
Register your Diabetes Health Username here.
Have Your Say...