Metformin Bests Glipizide in Reducing Cardio Events

Metformin Bests Glipizide in Reducing Cardio Events

| Jan 20, 2013

A Chinese research study of diabetes patients with coronary heart disease concludes that metformin is more effective than glipizide in reducing the risk of major cardiovascular events, such as stroke and heart attack.

Researchers at the Shanghai Jiao Tong University School of Medicine studied 304 patients, ages 36 to 80, over a five-year period. The patients were randomly assigned either the sulfonylurea glipizide (30 mg daily) or metformin (1.5 g daily) for three years.

At the start of the study, the baseline A1c for the overall patient group was 7.6%. Within six months, the A1c for the glipizide group fell to 7.1% and to 7.0% for the metformin group.
By the end of the study, 35.1 percent of patients on glipizide had experienced a CV event compared with 25 percent of the patients taking metformin.

Researchers said that this was the first known head-to-head comparison of the two drugs' ability to affect the incidence of CV events. Glipizide, or similar sulfonylureas, and metformin are the drugs doctors are most likely to prescribe to newly diagnosed diabetes patients.

On explanation for metformin's superior performance may be that it has antiatherosclerotic properties-the ability to help blood vessels resist the hardening associated with diabetic inflammation.

An abstract of the study is available online.

Click Here To View Or Post Comments

Categories: A1C, Diabetes Health, Diabetes Health Magazine, Diabetic, Glipizide, Metformin, Research

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...

Username: Password:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.