Weekly Type 2 Drug to Be Delivered Via Needle Patch

Zosano diagram shows how micro-needles penetrate to the epidermis

| Feb 24, 2014

A recent agreement between Zosano Pharma, Inc. and Novo Nordisk could lead to the introduction of a once-weekly drug for type 2s that is administered via a micro-needle patch system.

The drug, now under development by Novo Nordisk, is semaglutide, a GLP-1 (glucagon-like peptide) receptor agonist that the company is hoping to introduce as a one-a-week therapy. GLP-1s stimulate the release of insulin while also curbing the production of glucagon.

Current GLP-1 drugs on the market include Byetta and Bydureon (exenatide) from Amylin Pharmaceuticals and AstraZeneca Pharmaceuticals, and Victoza (liraglutide) from Novo Nordisk. Bydureon is a long-acting GLP-1 that users inject once ever seven days. Novo's introduction of semaglutide would allow it to compete with its own weekly therapy.

Where Novo could gain a competitive advantage is by offering a drug delivery method that bypasses traditional needle injection. According to Zosano, its micro-needle patch delivers therapeutic compounds through the skin, providing needle- and pain-free drug delivery. The company has tested the patch system in more than 450 patients with over 20,000 patches successfully applied in Phase 1 and Phase 2 clinical studies.

Under terms of the agreement, Zosano will grant Novo Nordisk a worldwide, exclusive license to develop and commercialize its GLP-1 analogues using Zosano's micro-needle patch system.

Aside from payments to Zosano as Novo's GLP-1 sales reach certain regulatory and sales milestones, the company will also receive royalties on sales of products, and receive development support, as well as reimbursement for all development and manufacturing costs.

Click Here To View Or Post Comments

Categories: Amylin Pharmaceuticals, AstraZeneca Pharmaceuticals, Bydureon, Byetta, Exenatide, GLP-1, Liraglutide, Micro-Needle Patch, Novo Nordisk, Semaglutide, Type 2, Victoza, Zosano Pharma


Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • What's on the Horizon with Diabetes Research and Therapy
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Latest
Popular
Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Comments


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.